5 terminated, 4 completed, 3 not yet recruiting, 3 recruiting. 8 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 2, Recruiting 2, Terminated 2, Not yet recruiting 1, Unknown 1 |
| Phase 3 | 1 | Terminated 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Left Bundle Branch Block: new trials by email Literature Review of Left Bundle Branch Block trials Research Report on Left Bundle Branch Block
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI Left bundle branch area pacing with pacemaker, Implantation loop recorder - TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block | Not applicable | Not yet recruiting | University Hospital, Clermont-Ferrand | 700 | 2026-10-15 | 2026-11-02 |
| REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints Physiologic cardiac resynchronization using conduction system pacing and selective LV lead optimization. - Heart Failure - NYHA II - IV, Left Bundle Branch Area Pacing | Not yet recruiting | University of Pecs | 50 | 2026-06-29 | 2026-07-10 | |
| Machine Learning for Diagnosis of Occlusive MI in LBBB Patients Digital 12-Lead ECG Analysis and Invasive Coronary Angiography - Acute Myocardial Infarction (AMI), Left Bundle Branch Block | Recruiting | Konya City Hospital | 50 | 2026-06-01 | 2026-06-02 | |
| EArly Effect of Glucocorticoid on Incidence of Persistent Left BundlE Branch Block (LBBB) Post-TAVR (EAGLE-TAVR Trial) Methylprednisolone (Corticosteroid), Placebo - Transcatheter Aortic Valve Replacemen, Left Bundle Branch Block | Phase 4 | Not yet recruiting | Xiao-dong Zhuang | 200 | 2025-01-01 | 2025-01-07 |
| UHF ECG in LBBB and Response to CRT Prediction LBBAP CRT device implantation, BVP-CRT - Left Bundle Branch Block, Left Bundle Branch Area Pacing | Not applicable | Recruiting | Faculty Hospital Kralovske Vinohrady | 200 | 2024-05-01 | 2025-07-14 |
| Clinical Efficacy and Safety of Left Bundle Branch Area Pacing Using Quantitative Guidance of Multimodal Data in the Treatment of Heart Failure Apply multimodal data fusion for quantitative guidance of left bundle branch region pacing, Conventional Biventricular Pacing - Heart Failure, Left Bundle Branch Block | Not applicable | Recruiting | Second Affiliated Hospital of Nanchang University | 100 | 2024-03-01 | 2026-09-11 |
| Acute Hemodynamic Effects of Pacing the His Bundle in Heart Failure Temporary His bundle pacing - Heart Failure, Systolic, Left Bundle Branch Block | Not applicable | Terminated | Region Skane | 2 | 2021-09-01 | 2025-02-28 |
| HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients HV measurement - Left Bundle Branch Block, Transcatheter Aortic Valve Replacement | Unknown | Maastricht University Medical Center | 100 | 2016-01-01 | 2016-01-20 | |
| Myocardial Work and Metabolism in CRT Cardiac resynchronisation therapy, Echocardiography, Magnetic Resonance Imaging - Left Ventricular Dyssynchrony, Heart Failure | Not applicable | Unknown | Universitaire Ziekenhuizen KU Leuven | 200 | 2015-09-01 | 2020-01-09 |
| Adaptive CRT Effect on Electrical Dyssynchrony Adaptive cardiac resynchronization therapy, Conventional Cardiac Resynchronization Therapy - Cardiomyopathy, Heart Failure | Not applicable | Completed | Larisa Tereshchenko | 32 | 2015-04-01 | 2025-03-20 |
| Left Bundle Branch Block ECG Characteristics in the Evaluation of Acute Coronary Syndrome None - no intervention, observational study - Left Bundle Branch Block | Terminated | Duke University | 8 | 2014-11-01 | 2015-09-28 | |
| MADIT ASIA Cardiac Resynchronization Trial Two-lead CRT-P - Congestive Heart Failure, Left Bundle Branch Block | Phase 3 | Terminated | Boston Scientific Corporation | 1 | 2014-02-01 | 2014-04-30 |
| EP-Catheter Guided CS-Lead Implantation Heart Failure, Reduced Left Ventricular Ejection Fraction | Completed | University of Cologne | 120 | 2013-08-01 | 2013-08-14 | |
| MIRACLE EF Clinical Study CRT-P Implant, CRT-P OFF - Congestive Heart Failure, Left Bundle Branch Block | Not applicable | Terminated | Medtronic Cardiac Rhythm and Heart Failure | 44 | 2012-12-01 | 2017-11-06 |
| QT Interval in Patients With Pacemaker Dependency High Degree AV-block, Left Bundle Branch Block | Completed | University of Magdeburg | 180 | 2012-03-01 | 2016-10-28 | |
| High Septal Pacing for Cardiac Resynchronization Therapy Cardiac Pacing - Heart Failure, Left Bundle Branch Block | Terminated | Boston Scientific Corporation | 15 | 2011-08-01 | 2012-06-21 | |
| Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging Cardiac Resynchronization Therapy (CRT) implantation - Heart Failure, Systolic, Left Bundle Branch Block | Not applicable | Completed | Emory University | 38 | 2010-06-01 | 2015-01-21 |
Bundle-Branch Block (17) · Heart Failure (8) · Heart Failure, Systolic (4) · Cardiomyopathies (2) · Chest Pain (1) · Coronary Occlusion (1) · Heart Diseases (1) · Myocardial Infarction (1) · Thrombosis (1)
Arrhythmias, Cardiac (17) · Cardiac Conduction System Disease (17) · Cardiovascular Diseases (17) · Heart Block (17) · Pathologic Processes (17) · Pathological Conditions, Signs and Symptoms (17) · Heart Diseases (16) · Coronary Disease (1) · Embolism and Thrombosis (1) · Heart Failure (1) · Infarction (1) · Ischemia (1) · Myocardial Ischemia (1) · Necrosis (1) · Neurologic Manifestations (1)
Cardiac Resynchronization Therapy (2) · Adrenal Cortex Hormones (1) · Drug Implants (1) · Magnetic Resonance Spectroscopy (1) · Methylprednisolone (1) · Observation (1)
Boston Scientific Corporation (2) · Duke University (1) · Emory University (1) · Faculty Hospital Kralovske Vinohrady (1) · Konya City Hospital (1) · Larisa Tereshchenko (1) · Maastricht University Medical Center (1) · Medtronic Cardiac Rhythm and Heart Failure (1) · Region Skane (1) · Second Affiliated Hospital of Nanchang University (1) · Universitaire Ziekenhuizen KU Leuven (1) · University Hospital, Clermont-Ferrand (1) · University of Cologne (1) · University of Magdeburg (1) · University of Pecs (1)
China (3) · United States (3) · Germany (2) · India (2) · Sweden (2) · Belgium (1) · Czechia (1) · France (1) · Hong Kong (1) · Hungary (1) · Japan (1) · Malaysia (1) · Netherlands (1) · Norway (1) · Russia (1)
Alexander T Limkakeng, MD (1) · Arthur J. Moss, M.D. (1) · Cecilia Linde, MD PhD (1) · Jens-Uwe Voigt, MD, PhD (1) · Larisa Tereshchenko, MD, PhD (1) · Michael S. Lloyd, MD (1) · Oscar Braun, MD PhD (1) · Otto A Smiseth, MD, PhD (1) · Rasmus Borgquist, MD PhD (1) · Samir Said, Dr. (1)
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