30 recruiting, 18 completed, 18 not yet recruiting, 2 enrolling by invitation. 55 Not applicable, 1 Early Phase 1, 1 Phase 3, 1 Phase 4.
Follow Knee Osteoarthristis: new trials by email Literature Review of Knee Osteoarthristis trials Research Report on Knee Osteoarthristis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis | Not applicable | Not yet recruiting | Pulse Wave USA | 60 | 2027-09-25 | 2026-05-05 |
| Clinical Evaluation of TrHCROSS® for Different Joints TrHCROSS®, Monovisc - Joint Osteoarthritis, Knee Osteoarthristis | Not applicable | Not yet recruiting | i+Med S.Coop. | 150 | 2026-12-01 | 2026-10-13 |
| The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults. Geriatric 5Ms framework, Exercises PT - Rehabilitation, Excercise | Not applicable | Not yet recruiting | King Saud University | 40 | 2026-11-15 | 2026-08-31 |
| Clinical Validation of SMARTDIAGO for Remote Functional Assessment of Musculoskeletal Conditions SMARTDIAGO Remote Functional Assessment - Knee Osteoarthristis, Hip Osteoarthritis | Not yet recruiting | University of Chile | 350 | 2026-11-02 | 2026-10-19 | |
| Medication vs. Meditation for Chronic Knee Osteoarthritis Oral diclofenac potassium 50 mg, Mindfulness meditation - Knee Osteoarthristis | Early Phase 1 | Not yet recruiting | Florida State University | 30 | 2026-10-01 | 2026-09-23 |
| Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee Peripheral Electrical Stimulation (PES), Paired Pulse Electrical Stimulation (ppES) - Knee Osteoarthristis, Knee Pain Arthritis | Not applicable | Not yet recruiting | Northeastern University | 50 | 2026-09-01 | 2026-09-22 |
| E-Health Lifestyle Intervention for Arthritis: A Pilot RCT on Feasibility Digital Health Intervention, Inactivated Smartband for Activity Monitoring - Knee Osteoarthristis, Obesity & Overweight | Not applicable | Not yet recruiting | The University of Hong Kong | 50 | 2026-09-01 | 2026-08-25 |
| Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems Platelet Rich Plasma, Emcyte PurePRP Supraphysiologic Concentrating System, APEX Biologix XCELL PRP System - Knee Osteoarthristis, Cartilage Damage | Phase 4 | Recruiting | University of California, San Francisco | 20 | 2026-09-01 | 2026-08-18 |
| The NTU JO-SMART Study NTU-JO Smart Program - Knee Osteoarthristis, Diabetes (DM) | Not applicable | Recruiting | National Taiwan University Hospital | 312 | 2026-08-01 | 2026-07-24 |
| Digitally Supported Short-Term Prehabilitation Before Total Knee Replacement EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Usual Care Group - Knee Osteoarthristis, Total Knee Replacement | Not applicable | Not yet recruiting | Ludwig Boltzmann Institute for Digital Health and Prevention | 60 | 2026-07-15 | 2026-07-14 |
| Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis Sensory-Modulated Graded Weight-Bearing Physiotherapy - Knee Osteoarthristis | Not applicable | Recruiting | Shifa Tameer-e-Millat University | 52 | 2026-07-13 | 2026-09-16 |
| Digital Course and Precision Rehabilitation for Knee Osteoarthritis and Older Adults: Integration of Multisensory Stimulation and Digital Twin Technology digital rehabilitation exercise courses combined with multisensory stimulation, Home exercises based on therapist education, Gait retraining combined with neuromuscular electrical stimulation - Knee Osteoarthristis, Healthy Adults | Not applicable | Recruiting | National Taiwan University Hospital | 100 | 2026-07-01 | 2026-07-14 |
| Close Chain and Open Chain Exercises With Blood Flow Restriction in Knee Osteoarthritis Closed kinetic chain exercises with blood flow restriction, Open kinetic chain exercises with blood flow restriction - Knee Osteoarthristis | Not applicable | Recruiting | Riphah International University | 40 | 2026-06-30 | 2026-07-20 |
| Blood Flow Restriction Training in Knee Osteoarthritic Patients Blood flow restriction training with Floss band, Blood flow restriction training with pneumatic cuff - Knee Osteoarthristis | Not applicable | Recruiting | Riphah International University | 46 | 2026-06-30 | 2026-07-20 |
| Outpatient Physiotherapy vs. mHealth Exercise and Self-Management for Knee Osteoarthritis (MOKneeTOR) MOKneeTOR with standard app configuration, Hospital-based outpatient rehabilitation program, MOKneeTOR with standard app configuration and enhanced personalisation - Knee Osteoarthristis | Not applicable | Recruiting | Singapore General Hospital | 160 | 2026-06-18 | 2026-09-02 |
| BFR Training and Knee Osteoarthritis Standard Treatment, Pain neuroscience education, Blood flow restriction training - Knee Osteoarthristis | Not applicable | Recruiting | University of Hail | 90 | 2026-06-15 | 2026-09-10 |
| Aquatic Exercise in Patients With Knee Osteoarthritis Standard physical therapy, Hydrotherapy - Central Sensitization, Knee Osteoarthristis | Not applicable | Recruiting | Kirsehir Ahi Evran Universitesi | 60 | 2026-06-01 | 2026-10-20 |
| Knee Osteoartritis Genicular Nerve RF Ablation vs Alcohol Neurolysis genicular nerve block - Knee Osteoarthristis, Radiofrequency Ablation | Not applicable | Not yet recruiting | Sakarya University | 50 | 2026-05-01 | 2026-04-17 |
| Effect of Knee and Heel Off-Loader Brace With Non Weight Bearing Strength in Knee Osteoarthritis Knee and Heel Off-Loader Brace with NWB Strength Training, Conventional Knee Off-Loader Brace with NWB Strength Training - Knee Osteoarthristis | Not applicable | Not yet recruiting | Lahore University of Biological and Applied Sciences | 20 | 2026-05-01 | 2026-05-28 |
| Effects of Intermittent Versus Continuous Blood Flow Restriction Training on Pain, Functional Ability, Muscle Strength and Exercise Perception Among Female Patients With Grade II Knee Osteoarthritis Intermittent blood flow training (iBFR), Continuous blood flow training (cBFR) - Knee Osteoarthristis | Not applicable | Completed | Lahore University of Biological and Applied Sciences | 84 | 2026-05-01 | 2026-07-23 |
Showing 20 of 71. Sign in to see all of them.
Osteoarthritis, Knee (25) · Osteoarthritis (12) · Pain (9) · Osteoarthritis, Hip (4) · Motor Activity (3) · Arthritis (2) · Joint Diseases (2) · Musculoskeletal Diseases (2) · Obesity (2) · Overweight (2) · Agnosia (1) · Anterior Cruciate Ligament Injuries (1) · Chronic Pain (1) · Depression (1) · Diabetes Mellitus (1)
Rheumatic Diseases (36) · Musculoskeletal Diseases (35) · Arthritis (34) · Joint Diseases (34) · Osteoarthritis (24) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (13) · Neurologic Manifestations (11) · Behavior (4) · Nutritional and Metabolic Diseases (3) · Body Weight (2) · Bone Diseases (2) · Metabolic Diseases (2) · Nervous System Diseases (2) · Nutrition Disorders (2)
Exercise (4) · Arthroplasty, Replacement, Knee (2) · Blood Flow Restriction Therapy (2) · Hyaluronic Acid (2) · Acupuncture Therapy (1) · Cognitive Behavioral Therapy (1) · Diathermy (1) · Diclofenac (1) · Diphosphonates (1) · Dosage Forms (1) · Electric Stimulation Therapy (1) · Embolization, Therapeutic (1) · Exercise Therapy (1) · Extracorporeal Shockwave Therapy (1) · Hydrotherapy (1)
Lahore University of Biological and Applied Sciences (3) · National Taiwan University Hospital (3) · Riphah International University (3) · Foundation University Islamabad (2) · Sakarya University (2) · The University of Hong Kong (2) · University of Karachi (2) · Ankara City Hospital Bilkent (1) · Bezmialem Vakif University (1) · Cairo University (1) · Chang Gung Memorial Hospital (1) · Diakonhjemmet Hospital (1) · Eighth Affiliated Hospital, Sun Yat-sen University (1) · Elsan (1) · Eskisehir Osmangazi University (1)
Pakistan (10) · Turkey (Türkiye) (10) · United States (9) · Saudi Arabia (4) · Taiwan (4) · China (3) · Egypt (2) · Georgia (2) · Germany (2) · Hong Kong (2) · Singapore (2) · Austria (1) · Belgium (1) · Chile (1) · Denmark (1)
Aftab Ahmed Mirza Baig, PhD (2) · Basit Ansari, PhD (2) · Muhammad Affan Iqbal, PhD* (2) · Amany Mohammed Shebl, Professor (1) · Anne Therese Tveter, PhD (1) · Anthony Luke, MD (1) · Asit Shah, MD, PhD (1) · Cameron A Hall, DC, PhD (1) · Chien-Hsieh Chiang, MD, MPH, PhD (1) · Daniela Wurhofer, Dr. (1) · Danish Hassan, PhD (1)
PMID 16084806, PMID 17131133, PMID 18003941, PMID 18338277, PMID 18496246, PMID 19887210, PMID 20091539, PMID 20500555, PMID 21907813, PMID 22412194, PMID 22665349, PMID 23973136, PMID 24993956, PMID 25155652, PMID 26267003, PMID 26762299, PMID 31675184, PMID 32085760, PMID 37745043, PMID 37892772, PMID 38102013, PMID 38131988, PMID 38818397, PMID 38819473, PMID 39451492, PMID 39597042, PMID 42751721
R01AG050305 (1), R01AG085712 (1)