52 completed, 14 unknown, 8 not yet recruiting, 5 recruiting. 54 Not applicable, 7 Phase 4, 4 Phase 3, 2 Early Phase 1, 2 Phase 2.
Follow Knee Arthroplasty: new trials by email Literature Review of Knee Arthroplasty trials Research Report on Knee Arthroplasty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Skin Closure in Prosthetic Joint Surgery: Comparative Evaluation of the "Barbed Sutures and Skin Glue" Technique (Cica-Pro) primary knee replacement, Primary hip replacement. - Surgical Wound, Knee Arthroplasty | Not applicable | Not yet recruiting | Groupe Hospitalier Diaconesses Croix Saint-Simon | 400 | 2026-10-15 | 2026-08-06 |
| Anaesthesia for Hip and Knee Arthroplasty (SPIGA) Spinal anaesthesia, General anaesthesia - Hip Arthroplasty, Knee Arthroplasty | Not applicable | Not yet recruiting | Zealand University Hospital | 3000 | 2026-10-01 | 2026-09-29 |
| Knee Positioning After Total Knee Replacement Knee Flexion, Standard Care - Knee Arthroplasty | Not applicable | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 150 | 2026-10-01 | 2026-10-07 |
| Feasibility of an Early Home-based Cycling Intervention After Knee Arthroplasty Early home-based stationary cycling, Usual care: home-based exercise programme - Knee Osteoarthritis, Knee Arthroplasty | Not applicable | Recruiting | Central Jutland Regional Hospital | 24 | 2026-09-21 | 2026-10-02 |
| Knee Arthroplasty Recovery With Transcranial Direct Current Stimulation Active tDCS Stimulation, Sham tDCS Stimulation - Knee Arthroplasty, Transcranial Direct Current Stimulation | Not applicable | Not yet recruiting | Women's College Hospital | 70 | 2026-05-01 | 2026-01-20 |
| The Impact of Patient Education Delivered Through Virtual Reality education - Knee Arthroplasty | Not applicable | Not yet recruiting | Ankara Yildirim Beyazıt University | 70 | 2026-01-12 | 2026-01-22 |
| Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty Total Knee Arthroplasty, Knee Arthroplasty | Not yet recruiting | Copenhagen University Hospital, Hvidovre | 40000 | 2026-01-01 | 2025-07-31 | |
| Effectiveness, Satisfaction, and Usability of Virtual Reality in the Management of Postoperative Pain in Patients Undergoing Knee Arthroplasty VIRTUAL REALITY - Knee Arthroplasty | Not applicable | Not yet recruiting | Universidad Francisco de Vitoria | 45 | 2025-12-27 | 2025-12-16 |
| A Holistic Evaluation of the Effects of Healing Nursing Care Interventions on Frail Patient Undergoing Knee Arthroplasty and Their Caregivers nursing care - Knee Arthroplasty | Not applicable | Completed | Ataturk University | 100 | 2025-12-01 | 2026-09-08 |
| Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App KneeApp - Knee Osteoarthritis, Knee Arthroplasty | Not applicable | Recruiting | Technical University of Munich | 1250 | 2025-10-01 | 2026-04-06 |
| Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty Ketamine, Standard Analgesia - Knee Arthroplasty, Postoperative Pain | Not applicable | Completed | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | 100 | 2025-07-01 | 2026-03-02 |
| Incidence of Chronic Pain in Patients Undergoing Knee Arthroplasty Within a Fast-Track Protocol Chronic Post Surgical Pain, Functional Recovery | Active not recruiting | University Hospital, Ghent | 153 | 2025-02-24 | 2026-06-29 | |
| Effect of Music Listened During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels Binaural beat music recital - Spinal Anesthesia, Knee Arthroplasty | Not applicable | Recruiting | Nuh Naci Yazgan University | 40 | 2025-02-01 | 2025-08-20 |
| The Dubousset Functional Test in Total Knee Arthloplasty Knee Arthroplasty | Not yet recruiting | Alanya Alaaddin Keykubat University | 60 | 2024-11-15 | 2024-10-09 | |
| Postoperative Analgesis in Total Knee Arthroplasty Peripheral nerve block methods - Knee Arthroplasty | Completed | Senay Canikli | 70 | 2024-07-22 | 2024-11-25 | |
| Customized Knee Arthroplasty With or Without Posterior Cruciate Ligament Retention: A CR-PS Approach Implantation surgery for CR and PS knee-joint prostheses used in the orthopedic surgery department's routine practice - Knee Arthroplasty, Osteoarthritis, Knee | Not applicable | Active not recruiting | Groupe Hospitalier Diaconesses Croix Saint-Simon | 140 | 2024-03-07 | 2026-08-11 |
| The Impact of Web-Based Education on Self-Care Power, Self-Efficacy, and Quality of Life in Knee Arthroplasty Patients. Web-based education - Knee Arthroplasty | Not applicable | Completed | KTO Karatay University | 67 | 2024-03-01 | 2025-03-07 |
| Tactile Incentiviser Improves Partial Weight Bearing After Lower-Limb Surgery mechanical feedback insole, Standard physiotherapy without feedback device - Femoral Fractures, Pelvic Fractures | Not applicable | Completed | Università degli Studi dell'Insubria | 34 | 2024-01-01 | 2025-05-25 |
| Increased Perioperative Communication Program in Knee Arthroplasty increased perioperative communication program - Knee Arthroplasty, Postoperative Complications | Not applicable | Completed | Hacettepe University | 70 | 2023-11-30 | 2024-10-03 |
| the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People Ciprofol - Sedation, ED95 | Early Phase 1 | Unknown | Second Hospital of Shanxi Medical University | 70 | 2023-11-29 | 2024-03-05 |
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Osteoarthritis, Knee (13) · Pain, Postoperative (8) · Osteoarthritis (7) · Pain (6) · Agnosia (5) · Motor Activity (4) · Arthritis (3) · Musculoskeletal Diseases (3) · Anxiety Disorders (2) · Femoral Fractures (2) · Hip Fractures (2) · Joint Diseases (2) · Osteoarthritis, Hip (2) · Patient Satisfaction (2) · Postoperative Complications (2)
Pathological Conditions, Signs and Symptoms (23) · Neurologic Manifestations (20) · Signs and Symptoms (20) · Rheumatic Diseases (16) · Joint Diseases (15) · Musculoskeletal Diseases (15) · Arthritis (14) · Pathologic Processes (12) · Osteoarthritis (10) · Postoperative Complications (10) · Behavior (9) · Nervous System Diseases (9) · Pain (8) · Neurobehavioral Manifestations (6) · Mental Disorders (5)
Ropivacaine (7) · Arthroplasty, Replacement, Knee (6) · Rehabilitation (4) · Sodium Chloride (3) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (2) · Anesthesia, Spinal (2) · Dexmedetomidine (2) · Acetaminophen (1) · Anesthesia, General (1) · Athletic Tape (1) · Catheters (1) · Cost-Benefit Analysis (1) · Educational Status (1) · Epinephrine (1) · Epoetin Alfa (1)
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (5) · Muğla Sıtkı Koçman University (3) · University of South Carolina (3) · BBraun Medical SAS (2) · Copenhagen University Hospital, Rigshospitalet (2) · Groupe Hospitalier Diaconesses Croix Saint-Simon (2) · Northwest Surgical Specialists, Vancouver (2) · Queen's University (2) · Second Hospital of Shanxi Medical University (2) · Yale University (2) · Alanya Alaaddin Keykubat University (1) · Anderson Orthopaedic Research Institute (1) · Ankara Yildirim Beyazıt University (1) · Assiut University (1) · Ataturk University (1)
United States (17) · Canada (12) · Turkey (Türkiye) (12) · France (7) · Denmark (4) · China (3) · Austria (2) · Germany (2) · Israel (2) · Italy (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Chile (1) · Egypt (1)
Donald Roberts, MD (2) · Jinlei Li, MD PhD (2) · Todd Borus, MD (2) · Abdurrahman Nalbant, PT,MSc (1) · Antony Tharian, M.D. (1) · Boris Teplykh, MD (1) · Brent A Lanting, MD (1) · Brent A Lanting, MD, FRCSC (1) · Brett Hayden, MD (1) · Bruce Menkowitz, MD (1) · Chiara Arienti, PhD(s) (1) · Christian Mittermaier, Dr (1)
PMID 17464603, PMID 19427164, PMID 21561303, PMID 21691907, PMID 22461750, PMID 22535806, PMID 22834681, PMID 23516031, PMID 23928707, PMID 24719708, PMID 24939863, PMID 25386752, PMID 26537815, PMID 26810604, PMID 27106963, PMID 27317871, PMID 27798674, PMID 29017803, PMID 29905615, PMID 31412056, PMID 32049833, PMID 33008432, PMID 34041719, PMID 34295303, PMID 34983040, PMID 36106651, PMID 36716898, PMID 38522799, PMID 39797350, PMID 41832534, PMID 42185960, PMID 42190239, PMID 42455081, PMID 7728691