190 completed. 190 Phase 3, 53 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 190 | Completed 190 |
| Phase 2 | 53 | Completed 53 |
Follow Insulin Resistance: new trials by email Literature Review of Insulin Resistance trials Research Report on Insulin Resistance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD) mibavademab - Generalized Lipodystrophy | Phase 3 | Completed | Regeneron Pharmaceuticals | 9 | 2024-12-16 | 2026-07-29 |
| Comparing Efficacy of Autologous Serum Eye Drops With and Without Insulin in Autoimmune Dry Eye. recombinant human insulin, Autologous serum - Dry Eye, Sjogren Syndrome | Phase 3 | Completed | Instituto de Oftalmología Fundación Conde de Valenciana | 25 | 2024-02-01 | 2026-08-27 |
| Effect of Green Tea on Obese Pediatrics With Prediabetes Green Tea Leaf Extract Decaffeinated, Metformin Hydrochloride 500 MG - PreDiabetes | Phase 3 | Completed | Ain Shams University | 90 | 2023-11-12 | 2026-01-06 |
| Semaglutide 2.4 mg in Patients With Poor Weight-loss Semaglutide 3 mg, Placebo - Obesity, Diabetes | Phase 3 | Completed | University College, London | 70 | 2022-11-01 | 2026-10-26 |
| Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care Outpatient therapy: 11 weeks of drug therapy with usual treatment + 4 weeks of closed-loop therapy - Type 1 Diabetes, Diabetes Mellitus, Type 1 | Phase 2 / Phase 3 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 28 | 2022-10-02 | 2025-01-22 |
| Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study Muscle5 and TRIM7, Mixed exercise - Overweight, Obesity | Phase 3 | Completed | Exerkine Corporation | 51 | 2022-08-15 | 2025-01-08 |
| Afrezza® INHALE-1 Study in Pediatrics Afrezza, Rapid-acting Insulin Analog, Basal Insulin - Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2 | Phase 3 | Completed | Mannkind Corporation | 319 | 2021-09-29 | 2025-05-06 |
| Antecedent Metabolic Health and Metformin Aging Study Metformin, Placebo oral tablet - Aging, Insulin Sensitivity | Phase 3 | Completed | Oklahoma Medical Research Foundation | 166 | 2020-07-29 | 2026-11-05 |
| ENAC Blockade and Arterial Stiffness Placebo - Cap, Amiloride Pill - Overweight and Obesity, Insulin Resistance | Phase 2 / Phase 3 | Completed | University of Missouri-Columbia | 137 | 2019-07-15 | 2025-12-30 |
| Efficacy and Safety of GP40071 Compared to NovoRapid® Penfill® in Type 1 Diabetes Mellitus Patients GP40071, NovoRapid® Penfill® - Diabetes, Diabetes Mellitus, Type 1 | Phase 3 | Completed | Geropharm | 264 | 2019-06-03 | 2020-07-23 |
| Effects of Local Insulin on Varicose Ulcers for Wound Healing Insulin Glargine, Saline - Chronic Venous Disease, Varicose Ulcer | Phase 3 | Completed | Hospital Central "Dr. Ignacio Morones Prieto" | 13 | 2019-06-01 | 2020-03-17 |
| The Bihormonal iLet Bionic Pancreas Feasibility Study Bihormonal iLet Bionic Pancreas, Insulin-only Bionic Pancreas, Dasiglucagon - Type 1 Diabetes Mellitus | Phase 2 / Phase 3 | Completed | Massachusetts General Hospital | 12 | 2019-05-15 | 2019-12-16 |
| Treating PCOS With Semaglutide vs Active Lifestyle Intervention Semaglutide 3mg and 7mg [Rybelsus], Weight loss diet - PCOS, Adolescent Obesity | Phase 2 / Phase 3 | Completed | University of Colorado, Denver | 60 | 2019-05-03 | 2025-11-25 |
| Switching From Protease Inhibitor/Ritonavir to Generic Single Tablet Regimen of Tenofovir Alafenamide/Emtricitibine/Dolutegravir generic single tablet TAF/FTC/DTG - HIV | Phase 3 | Completed | The HIV Netherlands Australia Thailand Research Collaboration | 170 | 2019-05-01 | 2024-02-28 |
| Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLira IDegLira, insulin degludec, Metformin - Type 2 Diabetes Mellitus | Phase 3 | Completed | Population Health Research Institute | 159 | 2019-04-23 | 2023-10-25 |
| Amla on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion Amla, Placebo - Metabolic Syndrome | Phase 2 / Phase 3 | Completed | University of Guadalajara | 28 | 2019-04-01 | 2022-11-08 |
| Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis Propylthiouracil, Methimazole - Hyperthyroidism, Graves Disease | Phase 3 | Completed | Universitas Indonesia | 36 | 2019-01-01 | 2021-11-12 |
| The Insulin-Only Bionic Pancreas Bridging Study iLet Bionic Pancreas insulin-only configuration with Humalog or Novolog, iLet Bionic Pancreas insulin-only configuration with Fiasp, Usual care - Type1 Diabetes Mellitus | Phase 2 / Phase 3 | Completed | Massachusetts General Hospital | 36 | 2018-07-09 | 2019-09-04 |
| Efficacy and Safety of Insulin RinGlar® Compared to Lantus® SoloStar® in Type 1 Diabetes Mellitus Patients Lantus Solostar, 100 Units/mL Subcutaneous Solution, Insulin RinGlar, 100 Units/mL Subcutaneous Solution - Diabetes Mellitus, Type 1, Diabetes Mellitus | Phase 3 | Completed | Geropharm | 180 | 2018-07-04 | 2019-07-17 |
| Berberine as Adjuvant Treatment for Schizophrenia Patients Berberine, Placebos, Antipsychotic Agents - Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders | Phase 2 / Phase 3 | Completed | The University of Hong Kong | 113 | 2018-04-25 | 2021-01-22 |
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Metabolic Syndrome (73) · Diabetes Mellitus, Type 2 (46) · Diabetes Mellitus (37) · Obesity (30) · Diabetes Mellitus, Type 1 (17) · Glucose Intolerance (10) · Hyperglycemia (10) · Inflammation (10) · Overweight (10) · Cardiovascular Diseases (9) · Hypertension (8) · Dyslipidemias (7) · Prediabetic State (6) · Diabetes, Gestational (5)
Hyperinsulinism (190) · Nutritional and Metabolic Diseases (190) · Glucose Metabolism Disorders (189) · Metabolic Diseases (186) · Endocrine System Diseases (95) · Pathological Conditions, Signs and Symptoms (54) · Diabetes Mellitus (49) · Signs and Symptoms (39) · Body Weight (36) · Nutrition Disorders (36) · Overnutrition (35) · Overweight (25) · Pathologic Processes (25) · Vascular Diseases (22)
Metformin (21) · Insulin (13) · Insulin Glargine (10) · Exercise (7) · Rosiglitazone (5) · 3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine (4) · Atorvastatin (4) · Diet (4) · salicylsalicylic acid (4) · Biguanides (3) · Cholecalciferol (3) · Docosahexaenoic Acids (3) · Insulin Aspart (3) · Liraglutide (3) · Pioglitazone (3)
AstraZeneca (5) · Brigham and Women's Hospital (5) · Tanabe Pharma Corporation (5) · Ain Shams University (4) · Geropharm (4) · Population Health Research Institute (4) · University of Colorado, Denver (4) · Catalysis SL (3) · Chinese Academy of Sciences (3) · Joslin Diabetes Center (3) · Massachusetts General Hospital (3) · National Nutrition and Food Technology Institute (3) · Sanofi (3) · Sanwa Kagaku Kenkyusho Co., Ltd. (3) · University of Erlangen-Nürnberg Medical School (3)
United States (50) · Canada (23) · Italy (14) · Germany (13) · Mexico (13) · China (9) · France (9) · Japan (9) · Australia (7) · United Kingdom (7) · Denmark (6) · Russia (6) · Egypt (5) · Puerto Rico (5) · Spain (5)
Kazuoki Kondo, MD (5) · Takashi Kadowaki, Professor (4) · Allison B. Goldfine, MD (3) · Xu Lin, MD, PhD (3) · David C Klonoff, M.D., F.A.C.P. (2) · Dick C Chan, PhD (2) · Francesco Squadrito, MD (2) · Guillermo Umpierrez, MD (2) · Hertzel Gerstein, MD (2) · Kathleen Jablonski, PhD (2) · Myrlene Staten, MD (2) · Natalia McInnes, MD (2)
PMID 20826632, PMID 31956422, PMID 32275191, PMID 37526194, PMID 11347758, PMID 12037147, PMID 1244564, PMID 14583175, PMID 15855569, PMID 16043738, PMID 16504835, PMID 16614616, PMID 16627388, PMID 16636217, PMID 16784922, PMID 17206944, PMID 17337495, PMID 17387446, PMID 17416370, PMID 17563348, PMID 17583798, PMID 18406632, PMID 18509206, PMID 18671796, PMID 19092145, PMID 19116237, PMID 19156626, PMID 19321570, PMID 19655124, PMID 19720420, PMID 19726779, PMID 19898642, PMID 20019677, PMID 20092585, PMID 20231565, PMID 20484482, PMID 20573639, PMID 20671408, PMID 20807873, PMID 20956707, PMID 21059830, PMID 21164548, PMID 21270268, PMID 21444887, PMID 21473976, PMID 21742107, PMID 21768545, PMID 21775749, PMID 21795429, PMID 21832112
2005 (2), U01DK074556 (2), 1RC1DK086132 (1), 2009 (1), 2015 (1), 5UL1TR000135 (1), F32DK068902 (1), KL2TR000136 (1), P50HL083813 (1), R01AG018198 (1), R01AG020076 (1), R01AG064951 (1), R01DK088078 (1), R01DK120612 (1), R01HL075771 (1)