376 completed. 376 Phase 3, 73 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 376 | Completed 376 |
| Phase 2 | 73 | Completed 73 |
Follow Inflammation: new trials by email Literature Review of Inflammation trials Research Report on Inflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjunctive Methylene Blue in Septic Shock Methylene Blue, Usual Care - Septic Shock | Phase 3 | Completed | Dr. Shannon M. Fernando | 50 | 2025-06-02 | 2026-03-19 |
| A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) VBI-S - Septic Shock, Sepsis | Phase 3 | Completed | Vivacelle Bio | 39 | 2024-08-06 | 2026-10-26 |
| Methylene Blue for the Treatment of Septic Shock Methylene Blue, Placebo - Septic Shock | Phase 3 | Completed | Northern Jiangsu People's Hospital | 88 | 2024-08-05 | 2026-02-04 |
| A Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Sonelokimab, Placebo - Hidradenitis Suppurativa | Phase 3 | Completed | MoonLake Immunotherapeutics AG | 422 | 2024-05-15 | 2026-08-12 |
| Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Sonelokimab, Placebo - Hidradenitis Suppurativa | Phase 3 | Completed | MoonLake Immunotherapeutics AG | 418 | 2024-05-14 | 2026-06-08 |
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Multimodal Vasopressor Strategy in Septic Shock Simultaneous administration of vasopressors, Successive administration of vasopressors - Shock, Septic | Phase 2 / Phase 3 | Completed | University Medical Centre Maribor | 79 | 2023-12-23 | 2026-03-31 |
| Strong Albumin Solutions in Patients With Septic Shock hyperoncotic human albumin solution, Buffered crystalloid solutions - Sepsis, Septic Shock | Phase 2 / Phase 3 | Completed | Manchester University NHS Foundation Trust | 47 | 2023-11-10 | 2026-02-09 |
| Late-onset Sepsis in Term and Pre-term Neonates and Infants up to 3 Months of Age Ceftobiprole medocaril - Neonatal Sepsis | Phase 3 | Completed | Basilea Pharmaceutica | 9 | 2023-08-06 | 2025-07-28 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults Procalcitonin measurement - Sepsis | Phase 3 | Completed | University of Oxford | 532 | 2023-07-26 | 2026-09-22 |
| The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock Group VTI, Group IVC - Septic Shock, Resuscitation | Phase 3 | Completed | Kasr El Aini Hospital | 90 | 2023-07-21 | 2025-04-29 |
| Effects of Immulina TM Supplements With PASC Patients Immulina TM, Placebo - Post Acute COVID-19 Syndrome | Phase 3 | Completed | University of Mississippi Medical Center | 101 | 2023-07-20 | 2026-07-31 |
| The Effect of Supplementation with Curcuminoids for the Improvement of Musculoskeletal Conditions in Sedentary Adults Supplement with curcuminoids, Physical excercise - Sedentariness and Well-being | Phase 3 | Completed | Lissette Ariza Corredor | 34 | 2023-07-05 | 2025-01-08 |
| Clinical Efficacy of Ulinastatin for Treatment of Sepsis With Systemic Inflammatory Response Syndrome Ulinastatin, Placebo - Sepsis | Phase 3 | Completed | Huashan Hospital | 120 | 2022-11-10 | 2026-09-23 |
| Dapagliflozin in Patients With Critical Illness Dapagliflozin 10mg Tab, Standard of Care - Critical Illness, Sepsis | Phase 3 | Completed | Hospital Israelita Albert Einstein | 507 | 2022-11-01 | 2023-10-31 |
| Treating Immuno-metabolic Depression With Anti-inflammatory Drugs Celecoxib 400mg, Placebo - Depressive Disorder, Major, Inflammation | Phase 3 | Completed | Amsterdam UMC, location VUmc | 94 | 2022-09-28 | 2026-09-21 |
| Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis Efzofitimod 3 mg/kg, Efzofitimod 5 mg/kg, Placebo - Pulmonary Sarcoidosis | Phase 3 | Completed | aTyr Pharma, Inc. | 268 | 2022-09-15 | 2026-06-04 |
| Study of Dexycu in Treating Intraocular Inflammation Dexycu, Placebo - Inflammation, Cataract | Phase 3 | Completed | Ocumension Therapeutics (Shanghai) Co., Ltd | 285 | 2022-08-22 | 2024-08-26 |
| Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study Muscle5 and TRIM7, Mixed exercise - Overweight, Obesity | Phase 3 | Completed | Exerkine Corporation | 51 | 2022-08-15 | 2025-01-08 |
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Sepsis (113) · Shock, Septic (71) · Cellulitis (32) · Pain (20) · Abscess (16) · Bacteremia (16) · Cataract (16) · Infections (16) · COVID-19 (14) · Neonatal Sepsis (13) · Candidemia (12) · Pneumonia (11) · Skin Diseases (11) · Bacterial Infections (10)
Pathological Conditions, Signs and Symptoms (376) · Pathologic Processes (371) · Infections (225) · Systemic Inflammatory Response Syndrome (180) · Shock (80) · Sepsis (64) · Bacterial Infections and Mycoses (54) · Respiratory Tract Diseases (51) · Signs and Symptoms (45) · Skin and Connective Tissue Diseases (45) · Lung Diseases (42) · Suppuration (42) · Respiratory Tract Infections (34) · Skin Diseases, Infectious (33)
Vancomycin (14) · Saline Solution (13) · Sodium Chloride (12) · Hydrocortisone (10) · Ascorbic Acid (9) · Meropenem (8) · Fluconazole (7) · Linezolid (7) · Trimethoprim, Sulfamethoxazole Drug Combination (7) · Aztreonam (6) · Daptomycin (6) · Norepinephrine (6) · Fatty Acids, Omega-3 (5) · Loteprednol Etabonate (5) · Micafungin (5)
Bausch & Lomb Incorporated (10) · Pfizer (7) · Radboud University Medical Center (6) · Amgen (5) · Astellas Pharma Inc (5) · Sirion Therapeutics, Inc. (5) · Ain Shams University (4) · Assistance Publique - Hôpitaux de Paris (4) · Eli Lilly and Company (4) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (4) · McMaster University (4) · National Cancer Institute (NCI) (4) · University of Versailles (4) · Ache Laboratorios Farmaceuticos S.A. (3) · Durata Therapeutics Inc., an affiliate of Allergan plc (3)
United States (143) · Canada (51) · France (49) · Germany (45) · Italy (44) · Spain (43) · United Kingdom (38) · Brazil (35) · Netherlands (27) · Belgium (26) · Russia (26) · Poland (20) · India (19) · Australia (17) · Austria (17)
Roger Vogel, MD (4) · Allison B. Goldfine, MD (3) · Konrad Reinhart, MD (3) · Anders Perner, MD, PhD (2) · Andrea Morelli, MD (2) · Andrew Schwartz, MD (2) · Avroy A. Fanaroff, MD (2) · Charles R. Bauer, MD (2)
PMID 37316690, PMID 30018799, PMID 30597021, PMID 30716446, PMID 31077258, PMID 31909868, PMID 34536218, PMID 34741280, PMID 34905144, PMID 34922058, PMID 37916745, PMID 12424394, PMID 14977340, PMID 19101421, PMID 20695801, PMID 21115456, PMID 21147825, PMID 23984731, PMID 24136301, PMID 24635772, PMID 24897082, PMID 24935281, PMID 27370913, PMID 27810317, PMID 28459966, PMID 28597967, PMID 28670710, PMID 29358292, PMID 31280481, PMID 32965495, PMID 33438477, PMID 33599960, PMID 33891293, PMID 34976290, PMID 42192627, PMID 10933646, PMID 12145720, PMID 12563043, PMID 12600870, PMID 12946763, PMID 15121931, PMID 15121942, PMID 16352625, PMID 16356432, PMID 16615955, PMID 16636217, PMID 16818526, PMID 16914701, PMID 16973975, PMID 16978417
2005 (4), 2009 (3), 2017 (3), 2018 (2), U01DK074556 (2), U10HD021364 (2), U10HD021373 (2), U10HD021385 (2), U10HD021397 (2), U10HD021415 (2), 2004 (1), 2008 (1), 2014 (1), 2015 (1), 2016 (1)