81 completed, 30 recruiting, 16 unknown, 13 terminated. 30 Phase 2, 27 Not applicable, 20 Phase 3, 12 Phase 1, 8 Phase 4.
Follow Hypoparathyroidism: new trials by email Literature Review of Hypoparathyroidism trials Research Report on Hypoparathyroidism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism Parathyroid Allotransplant - Hypoparathyroidism | Not applicable | Withdrawn | University of Alabama at Birmingham | 2027-07-01 | 2026-08-21 | |
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| Efficacy, Safety, and Tolerability of Encaleret in Participants With Chronic Hypoparathyroidism Encaleret, Placebo - Hypoparathyroidism, Chronic Hypoparathyroidism | Phase 3 | Recruiting | Calcilytix Therapeutics, Inc., a BridgeBio company | 160 | 2026-08-31 | 2026-09-16 |
| A Study to Investigate Canvuparatide Compared With Placebo in Adult Patients With Hypoparathyroidism Canvuparatide, Placebo - Hypoparathyroidism | Phase 3 | Recruiting | MBX Biosciences | 160 | 2026-08-26 | 2026-10-20 |
| NIRAF-Guided Parathyroid Identification During Thyroidectomy Wearable Near-Infrared Autofluorescence Imaging System - Hypocalcemia, Hypoparathyroidism | Not applicable | Not yet recruiting | Ss. Cyril and Methodius University of Skopje | 280 | 2026-06-01 | 2026-06-01 |
| A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism Palopegteriparatide Experimental Arm, Palopegteriparatide Control Arm - Hypoparathyroidism, Endocrine System Diseases | Phase 3 | Recruiting | Ascendis Pharma Bone Diseases A/S | 36 | 2026-05-07 | 2026-10-20 |
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| A Study to Test the Effects and Safety of Palopegteriparatide in Adolescents With Long-term Hypoparathyroidism Palopegteriparatide - Hypoparathyroidism | Phase 3 | Recruiting | Ascendis Pharma A/S | 12 | 2026-04-22 | 2026-07-28 |
| A Cohort Study on the Safety and Efficacy of XH-02 in Treating Hypoparathyroidism Single subcutaneous injection, Multiple subcutaneous injection - Hypoparathyroidism | Phase 2 | Suspended | Peking Union Medical College Hospital | 60 | 2026-04-13 | 2026-09-28 |
| A Study to Assess the Amount of Palopegteriparatide in Breast Milk of Lactating Females Requiring YORVIPATH® (Palopegteriparatide) Palopegteriparatide - Hypoparathyroidism | Recruiting | Ascendis Pharma A/S | 10 | 2026-03-19 | 2026-08-07 | |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| A Global Pregnancy Registry to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to YORVIPATH® (Palopegteriparatide) During Pregnancy and Breastfeeding Palopegteriparatide - Hypoparathyroidism | Recruiting | Ascendis Pharma A/S | 50 | 2026-02-18 | 2026-03-02 | |
| Parathyroid Allotransplant for Treatment of Hypoparathyroidism Parathyroid Allotransplant - Hypoparathyroidism, Hypoparathyroidism Postprocedural | Phase 1 / Phase 2 | Recruiting | Peter Stock | 3 | 2026-01-15 | 2026-02-27 |
| The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment Pregnant Individuals, Aneuploidy | Recruiting | BillionToOne Inc. | 1000 | 2026-01-10 | 2026-10-15 | |
| Efficacy and Safety of Subcutaneous Injection of XH-02 in the Treatment of Adult Hypoparathyroidism Single subcutaneous injection, Multiple subcutaneous injection - Hypoparathyroidism | Phase 1 / Phase 2 | Suspended | Peking Union Medical College Hospital | 15 | 2025-11-17 | 2026-09-25 |
| Risk Factors for Hypoparathyroidism Following Thyroidectomy Post-Surgical Hypoparathyroidism | Recruiting | Tartu University Hospital | 300 | 2025-10-13 | 2026-05-13 | |
| Translation and Validation of the Hypoparathyroidism Patient Experience Scales (HPES) Questionnaire in Greek Questionnaire and Physical Exam - Hypoparathyroidism | Not yet recruiting | Aristotle University Of Thessaloniki | 200 | 2025-10-01 | 2025-09-08 | |
| Comparing PTeye-assisted Versus Conventional Total Thyroidectomy PTeye™ parathyroid detection system - Hypocalcemia, Parathyroid | Not applicable | Recruiting | The University of Hong Kong | 210 | 2025-09-16 | 2026-02-17 |
| Treatment With Indapamide in Patients With Post-Surgical Hypoparathyroidism Indapamide 1.5 MG SR, Placebo - Hypoparathyroidism Post-surgical | Phase 4 | Recruiting | Lars Rejnmark | 24 | 2025-08-01 | 2025-08-11 |
| Efficacy and Safety of XH02 for the Treatment of Hypoparathyroidism intravenous administration of PTH1-84 mRNA - Hypoparathyroidism | Early Phase 1 | Suspended | Peking Union Medical College Hospital | 6 | 2025-05-20 | 2026-10-16 |
Showing 20 of 155. Sign in to see all of them.
DiGeorge Syndrome (46) · Hypocalcemia (24) · Thyroid Neoplasms (9) · Parathyroid Diseases (8) · Thyroid Diseases (8) · 22q11 Deletion Syndrome (7) · Endocrine System Diseases (7) · Thymic aplasia (7) · Down Syndrome (6) · Hypercalciuria (6) · Hyperparathyroidism (6) · Immunologic Deficiency Syndromes (6) · Pseudohypoparathyroidism (6) · Turner Syndrome (5)
Endocrine System Diseases (148) · Parathyroid Diseases (147) · Musculoskeletal Diseases (61) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (58) · Genetic Diseases, Inborn (53) · Cardiovascular Diseases (50) · Heart Diseases (50) · Cardiovascular Abnormalities (49) · Chromosome Disorders (49) · Congenital Abnormalities (49) · Craniofacial Abnormalities (49) · Hemic and Lymphatic Diseases (49) · Lymphatic Abnormalities (49) · Lymphatic Diseases (49) · Musculoskeletal Abnormalities (49)
Parathyroid Hormone (6) · Teriparatide (6) · Blood Specimen Collection (5) · Indocyanine Green (3) · Thymus Extracts (3) · Calcium (2) · Calcium Carbonate (2) · Dexamethasone (2) · Drug Implants (2) · Ergocalciferols (2) · Injections, Subcutaneous (2) · Magnesium (2) · Methylphenidate (2) · Neuropsychological Tests (2) · Observation (2)
Shire (11) · Sumitomo Pharma Switzerland GmbH (7) · University of Aarhus (5) · Aristotle University Of Thessaloniki (4) · Ascendis Pharma A/S (4) · Hôpital le Vinatier (4) · Amorphical Ltd. (3) · Ascendis Pharma Bone Diseases A/S (3) · Calcilytix Therapeutics, Inc., a BridgeBio company (3) · Entera Bio Ltd. (3) · Fujian Medical University (3) · MBX Biosciences (3) · National Institute of Dental and Craniofacial Research (NIDCR) (3) · Peking Union Medical College Hospital (3) · Children's Healthcare of Atlanta (2)
United States (69) · France (20) · Denmark (19) · Canada (16) · Italy (15) · China (10) · Germany (9) · Netherlands (8) · Hungary (7) · Israel (7) · United Kingdom (7) · Greece (6) · Norway (6) · Australia (4) · Belgium (4)
M. Louise Markert, MD, PhD (5) · John P Bilezikian, MD (3) · Karen K Winer, M.D. (2) · Lars Rejnmark, DmSci, PhD (2) · Robert J Shprintzen, PhD (2) · Sophia Ish-Shalom, MD (2) · Stephan Eliez, Professor (2) · Yan Qin (2) · Agnes Linglart, MD, PhD (1) · Alexandra Chrisoulidou, M.D (1) · Alison Parker, PhD (1) · Anders OJ Bergenfelz, PhD (1)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 36018496, PMID 17284531, PMID 32738041, PMID 35974422, PMID 35696069, PMID 15100156, PMID 18155964, PMID 20978268, PMID 23607606, PMID 36271471, PMID 38691316, PMID 40709359, PMID 10417280, PMID 12642839, PMID 12702512, PMID 12820840, PMID 15100681, PMID 16282778, PMID 16814942, PMID 18333898, PMID 20063223, PMID 20375405, PMID 21310373, PMID 21519036, PMID 21565561, PMID 22005709, PMID 22090268, PMID 22281937, PMID 22464072, PMID 22590644, PMID 22617594, PMID 22742782, PMID 23215555, PMID 23613152, PMID 23711443, PMID 23712453, PMID 23914737, PMID 24135152, PMID 24207068, PMID 24388429, PMID 24622413, PMID 24687385, PMID 24785862, PMID 24948345, PMID 25004354
K12HD043494 (7), R01AI047040 (7), R01AI054843 (6), R56AI047040 (4), 2017 (2), 2008 (1), 2015 (1), 2016 (1), 2019 (1), R01DK069350 (1), R01HL084410 (1), R01HL157157 (1), R33MH085901 (1), R34MH091314 (1), R44DK138647 (1)