Parathyroid Diseases: Clinical Trials

373 completed, 78 recruiting, 76 unknown, 43 terminated. 123 Not applicable, 97 Phase 2, 84 Phase 3, 76 Phase 4, 44 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	123	Completed 73, Recruiting 15, Unknown 13, Terminated 8, Withdrawn 7, Enrolling by invitation 3, Active not recruiting 2, Not yet recruiting 2
Phase 2	97	Completed 61, Recruiting 9, Unknown 8, Terminated 6, Active not recruiting 5, Withdrawn 4, Not yet recruiting 2, Suspended 2
Phase 3	84	Completed 56, Recruiting 10, Terminated 7, Unknown 6, Active not recruiting 2, Withdrawn 2, Not yet recruiting 1
Phase 4	76	Completed 55, Terminated 7, Unknown 6, Recruiting 5, Withdrawn 2, Active not recruiting 1
Phase 1	44	Completed 37, Terminated 3, Recruiting 1, Suspended 1, Unknown 1, Withdrawn 1
Early Phase 1	7	Completed 3, Unknown 2, Recruiting 1, Suspended 1

Follow Parathyroid Diseases: new trials by email Literature Review of Parathyroid Diseases trials Research Report on Parathyroid Diseases

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism Parathyroid Allotransplant - Hypoparathyroidism	Not applicable	Withdrawn	University of Alabama at Birmingham		2027-07-01	2026-08-21
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes		Recruiting	Bettina Mittendorfer	100	2027-01-01	2026-05-07
Lenvatinib in Patients With Advanced Parathyroid Carcinoma Lenvatinib - Parathyroid Carcinoma	Phase 2	Not yet recruiting	Yonsei University	18	2026-11-01	2026-09-28
Parathyroid Adenoma Detection With Rubidium-82 Imaging PET/CT imaging with rubidium-82 - Parathyroid Adenomas, Hyperparathyroidism, Primary		Enrolling by invitation	Matthieu Pelletier-Galarneau, MD MSc	20	2026-11-01	2026-10-27
A Study of PLS240 in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis PLS240, Standard of Care - Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism	Phase 3	Not yet recruiting	Pathalys Pharma	56	2026-10-30	2026-10-22
Patient Navigation to Improve Surgical Access in Primary Hyperparathyroidism Scheduling Navigation, Without Scheduling Navigation - Hyperparathyroidism, Primary	Not applicable	Recruiting	University of Pennsylvania	76	2026-10-01	2026-08-27
Osteoporosis & Renal Disease: Research in Primary Health Care Services Fracture risk assessment tool (FRAX), Dual-Energy X-ray Absorptiometry (DXA) - Osteoporosis, Chronic Kidney Disease Mineral and Bone Disorder		Not yet recruiting	Universidade do Porto	622	2026-10-01	2026-09-30
Hyperparathyroidism and Dialysis Adequacy in Hemodialysis Patients Hyperparathyroidism, Secondary, Kidney Failure, Chronic		Not yet recruiting	Assiut University	130	2026-09-10	2026-09-15
Efficacy, Safety, and Tolerability of Encaleret in Participants With Chronic Hypoparathyroidism Encaleret, Placebo - Hypoparathyroidism, Chronic Hypoparathyroidism	Phase 3	Recruiting	Calcilytix Therapeutics, Inc., a BridgeBio company	160	2026-08-31	2026-09-16
NIRAF-camera Versus Conventional Surgery in Preoperative Imaging Negative Primary Hyperparathyroidism NIRAF-camera - Primary Hyperparathyroidism	Not applicable	Recruiting	The Cleveland Clinic	80	2026-08-31	2026-09-11
A Study to Investigate Canvuparatide Compared With Placebo in Adult Patients With Hypoparathyroidism Canvuparatide, Placebo - Hypoparathyroidism	Phase 3	Recruiting	MBX Biosciences	160	2026-08-26	2026-10-29
Flurpiridaz F-18 PET/CT Imaging for Detecting Parathyroid Adenomas Flurpiridaz PET/CT - Hyperparathyroidism	Early Phase 1	Recruiting	University of Pennsylvania	20	2026-08-15	2026-11-02
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants CTAP101 - CKD Stage 3, CKD Stage 4	Phase 2	Recruiting	OPKO Health, Inc.	40	2026-08-05	2026-08-20
Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD Low-dose Colchicine at 0.5mg daily, Usual Care - Chronic Kidney Disease Mineral and Bone Disorder, Hypertension	Phase 2	Not yet recruiting	University of Texas Southwestern Medical Center	60	2026-07-01	2026-06-22
Medium Cut-Off and High-Flux Membranes on Mineral and Bone Metabolism in Hemodialysis Patients Medium Cut-Off Hemodialysis Membrane, High-Flux Hemodialysis Membrane - End Stage Kidney Disease (ESKD), Hemodialysis	Not applicable	Active not recruiting	Gazi University	30	2026-07-01	2026-09-14
NIRAF-Guided Parathyroid Identification During Thyroidectomy Wearable Near-Infrared Autofluorescence Imaging System - Hypocalcemia, Hypoparathyroidism	Not applicable	Not yet recruiting	Ss. Cyril and Methodius University of Skopje	280	2026-06-01	2026-06-01
Shortwave Infrared Surgical Imaging Device Study Observational study of SWIR imaging device in surgery - Cholecystitis, Cholecystitis, Chronic		Enrolling by invitation	Cision Vision, Inc.	50	2026-05-29	2026-08-04
A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism Palopegteriparatide Experimental Arm, Palopegteriparatide Control Arm - Hypoparathyroidism, Endocrine System Diseases	Phase 3	Recruiting	Ascendis Pharma Bone Diseases A/S	36	2026-05-07	2026-10-20
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder	Phase 2	Recruiting	Paul Szabolcs	25	2026-05-04	2026-05-15
Calcium Isotope Ratios to Assess Calcium Bone Balance in Dialysis Children Receiving Cinacalcet Supplementary blood samples and urines samples - Children Over 3 Undergoing Dialysis With Secondary Hyperparathyroidism		Recruiting	Hospices Civils de Lyon	20	2026-04-29	2026-05-22

Showing 20 of 626. Sign in to see all of them.

Narrower conditions

Hyperparathyroidism, Secondary (184)  ·  Hypoparathyroidism (111)  ·  Hyperparathyroidism (110)  ·  Hyperparathyroidism, Primary (101)  ·  Renal Insufficiency, Chronic (101)  ·  Chronic Kidney Disease-Mineral and Bone Disorder (73)  ·  Parathyroid Neoplasms (63)  ·  Kidney Failure, Chronic (50)  ·  DiGeorge Syndrome (46)  ·  Hypocalcemia (37)  ·  Vitamin D Deficiency (31)  ·  Thyroid Diseases (30)  ·  Hypercalcemia (29)  ·  Osteoporosis (27)

Broader conditions

Endocrine System Diseases (611)  ·  Hyperparathyroidism (305)  ·  Pathological Conditions, Signs and Symptoms (220)  ·  Nutritional and Metabolic Diseases (205)  ·  Pathologic Processes (204)  ·  Urogenital Diseases (200)  ·  Female Urogenital Diseases and Pregnancy Complications (199)  ·  Female Urogenital Diseases (198)  ·  Male Urogenital Diseases (198)  ·  Urologic Diseases (191)  ·  Metabolic Diseases (186)  ·  Disease Attributes (183)  ·  Chronic Disease (175)  ·  Kidney Diseases (174)

Interventions

Cinacalcet (59)  ·  paricalcitol (35)  ·  Calcitriol (20)  ·  etelcalcetide hydrochloride (18)  ·  Parathyroidectomy (15)  ·  1 alpha-hydroxyergocalciferol (14)  ·  Cholecalciferol (14)  ·  Vitamin D (13)  ·  Standard of Care (11)  ·  Blood Specimen Collection (10)  ·  Parathyroid Hormone (8)  ·  Teriparatide (8)  ·  Denosumab (7)  ·  Ergocalciferols (7)  ·  alfacalcidol (7)

Sponsors

Amgen (44)  ·  Abbott (13)  ·  AbbVie (prior sponsor, Abbott) (12)  ·  M.D. Anderson Cancer Center (12)  ·  Shire (11)  ·  Columbia University (10)  ·  Kyowa Kirin Co., Ltd. (10)  ·  Aristotle University Of Thessaloniki (9)  ·  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (9)  ·  University of Aarhus (9)  ·  OPKO Health, Inc. (7)  ·  Sumitomo Pharma Switzerland GmbH (7)  ·  KAI Pharmaceuticals (5)  ·  National Cancer Institute (NCI) (5)  ·  National Center for Research Resources (NCRR) (5)

Countries

United States (230)  ·  France (55)  ·  China (45)  ·  Italy (45)  ·  Denmark (43)  ·  Canada (31)  ·  Germany (30)  ·  Poland (26)  ·  Japan (25)  ·  Spain (21)  ·  United Kingdom (21)  ·  Belgium (20)  ·  Greece (20)  ·  Israel (20)  ·  Hungary (19)

Top investigators

Nancy D. Perrier, MD (8)  ·  Joel Melnick, MD (7)  ·  M. Louise Markert, MD, PhD (5)  ·  John P Bilezikian, MD (4)  ·  Smita Jha, M.D. (4)  ·  M D (3)  ·  Thomas Hope, MD (3)  ·  Thomas Nickolas, MD, MS (3)  ·  Ann Eldred, MD (2)  ·  Brendan Stack, MD (2)

Results publications

PMID 40576086, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 36018496, PMID 17284531, PMID 32738041, PMID 35974422, PMID 40668552, PMID 35696069, PMID 15100156, PMID 18155964, PMID 20943783, PMID 20978268, PMID 21544866, PMID 23607606, PMID 27532368, PMID 36271471, PMID 38691316, PMID 40709359, PMID 10417280, PMID 10654517, PMID 10898180, PMID 11114637, PMID 11114639, PMID 11229970, PMID 11576947, PMID 12642839, PMID 12702512, PMID 12820840, PMID 14668730, PMID 15100681, PMID 15284307, PMID 15522938, PMID 15663056, PMID 15689407, PMID 15698460, PMID 15711996, PMID 15726399, PMID 15828905, PMID 15930998, PMID 15983958, PMID 16105056, PMID 16125070, PMID 16282778, PMID 16540904, PMID 16785355, PMID 16792136

NIH funding

K12HD043494 (7), R01AI047040 (7), R01AI054843 (6), 2008 (4), R56AI047040 (4), 2017 (3), 2023 (3), R01CA212147 (3), 2009 (2), 2015 (2), 2016 (2), 2018 (2), R01DK032333 (2), R01DK073039 (2), R01DK084986 (2)