44 completed, 24 recruiting, 10 terminated, 6 unknown. 25 Phase 2, 22 Not applicable, 10 Phase 1, 7 Phase 3, 2 Phase 4.
Follow Lymphatic Abnormalities: new trials by email Literature Review of Lymphatic Abnormalities trials Research Report on Lymphatic Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome KP-001, Placebo - Venous Malformations, Lymphatic Malformations | Phase 3 | Recruiting | Kaken Pharmaceutical | 150 | 2026-05-13 | 2026-09-21 |
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| European Registry Study on Lymphatic Interventions Lymphatic intervention - Lymphatic Disorders, Plastic Bronchitis | Recruiting | Copenhagen University Hospital, Rigshospitalet | 500 | 2026-02-01 | 2026-01-21 | |
| Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic Malformations Bleomycin, doxycycline (tetracycline) - Lymphatic Abnormality | Phase 2 | Not yet recruiting | Basharat Hussain | 92 | 2026-01-26 | 2026-01-06 |
| The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment Pregnant Individuals, Aneuploidy | Recruiting | BillionToOne Inc. | 1000 | 2026-01-10 | 2026-10-15 | |
| Intralesional Bleomycin Sclerotherapy for Low-Flow Vascular Malformations of the Head and Neck Bleomycin (Bleocel 15) - Vascular Malformations, Venous Malformation | Phase 4 | Completed | University Of Anbar | 20 | 2025-08-25 | 2026-07-27 |
| Diagnostic Imaging of Vascular Malformations Using MSOT and ULM Multispectral Optoacoustic Tomography, Ultrasound Localization Microscopy - Vascular Malformation, Arteriovenous Malformation | Not yet recruiting | University Hospital Erlangen | 15 | 2025-08-01 | 2025-06-22 | |
| A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study) RLY-2608, Placebo - PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations | Phase 2 | Recruiting | Relay Therapeutics, Inc. | 277 | 2025-06-13 | 2026-08-25 |
| Radiofrequency Ablation of Vascular Anomalies Radiofrequency ablation alone - Vascular Anomalies | Not applicable | Not yet recruiting | Baylor College of Medicine | 15 | 2025-03-01 | 2025-01-31 |
| Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations Sirolimus (RAPAMUNE) - Lymphatic Malformation | Phase 2 / Phase 3 | Recruiting | West China Hospital | 150 | 2024-11-30 | 2024-12-31 |
| Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders Sertraline, Placebo - Neurodevelopmental Disorders, Autism | Phase 2 | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 130 | 2024-09-16 | 2026-07-27 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Bleomycin Intralesional Injections of Cystic Hygromas Intralesional Injections - Lymphatic Malformations | Not applicable | Completed | Delta University for Science and Technology | 30 | 2024-09-01 | 2026-04-28 |
| SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations QTORIN 3.9% Rapamycin Anhydrous Gel - Microcystic Lymphatic Malformation | Phase 3 | Active not recruiting | Palvella Therapeutics, Inc. | 51 | 2024-07-31 | 2026-03-27 |
| Institution of an Italian Registry and Biobank for Biological Sample Collection Genetic profiling of all eligible patients - Lymphatic Malformation, Lymphatic Abnormality | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 70 | 2024-06-27 | 2025-03-25 |
| Mindfulness Program for Adolescents With 22q11DS Aware Program - 22Q11 Deletion Syndrome | Not applicable | Completed | Innovation Research & Training | 110 | 2023-12-18 | 2025-04-29 |
| Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. Alpelisib, Placebo - Lymphatic Malformations | Phase 2 / Phase 3 | Recruiting | Novartis Pharmaceuticals | 232 | 2023-11-24 | 2026-10-09 |
| Using Transcranial Alternating Current Stimulation to Improve Executive Function in 22q11.2 Deletion Syndrome at-home tACS using Starstim-Home tES - 22Q11 Deletion Syndrome, tACS | Not applicable | Recruiting | Stephan Eliez | 40 | 2023-10-20 | 2025-12-02 |
| Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age TARA-002 - Lymphatic Malformation | Phase 2 | Recruiting | Protara Therapeutics | 38 | 2023-10-18 | 2026-08-24 |
Showing 20 of 91. Sign in to see all of them.
DiGeorge Syndrome (46) · Vascular Malformations (13) · Lymphangioma (8) · 22q11 Deletion Syndrome (7) · Thymic aplasia (7) · Down Syndrome (6) · Heart Defects, Congenital (6) · Immunologic Deficiency Syndromes (6) · Arteriovenous Malformations (5) · Hypoparathyroidism (5) · Klippel-Trenaunay-Weber Syndrome (5) · Turner Syndrome (5) · Williams Syndrome (5) · Chromosome Aberrations (4)
Hemic and Lymphatic Diseases (91) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (90) · Congenital Abnormalities (88) · Lymphatic Diseases (88) · Cardiovascular Diseases (68) · Cardiovascular Abnormalities (66) · Heart Diseases (53) · Musculoskeletal Diseases (52) · Craniofacial Abnormalities (50) · Musculoskeletal Abnormalities (50) · Chromosome Disorders (49) · Parathyroid Diseases (49) · Abnormalities, Multiple (48) · Endocrine System Diseases (48)
Sirolimus (4) · Bleomycin (3) · Thymus Extracts (3) · Alpelisib (2) · Blood Specimen Collection (2) · Drug Implants (2) · Exercise (2) · Methylphenidate (2) · Neuropsychological Tests (2) · Picibanil (2) · Risperidone (2) · Sclerotherapy (2) · Sildenafil Citrate (2) · Transplantation (2) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (1)
Sumitomo Pharma Switzerland GmbH (7) · Hôpital le Vinatier (4) · University of Aarhus (3) · West China Hospital (3) · Boston Children's Hospital (2) · Children's Healthcare of Atlanta (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · Medical College of Wisconsin (2) · Nanjing Children's Hospital (2) · National Center for Research Resources (NCRR) (2) · Progenity, Inc. (2) · Stanford University (2) · State University of New York - Upstate Medical University (2) · UMC Utrecht (2) · University of Arkansas (2)
United States (49) · France (10) · Australia (5) · China (5) · Germany (4) · Netherlands (4) · Switzerland (4) · Belgium (3) · Denmark (3) · Italy (3) · Spain (3) · United Kingdom (3) · Canada (2) · Ireland (2) · Argentina (1)
M. Louise Markert, MD, PhD (5) · Robert J Shprintzen, PhD (2) · Stephan Eliez, Professor (2) · Alfred T Lane, MD (1) · Alison Parker, PhD (1) · Anne Wheeler, PhD (1) · Bernice E. Morrow, PhD (1) · Bernice Morrow, PhD (1) · Beth Drolet, MD (1) · Chelsea Shope, MSCR (1) · Chiara Leoni (1) · Craig B. Langman (1)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 17284531, PMID 15100156, PMID 18155964, PMID 20978268, PMID 23607606, PMID 28782106, PMID 10417280, PMID 11527161, PMID 12642839, PMID 12702512, PMID 12820840, PMID 15100681, PMID 16282778, PMID 16418953, PMID 16814942, PMID 18333898, PMID 19043850, PMID 19117316, PMID 19407619, PMID 20375405, PMID 20843632, PMID 21310373, PMID 21519036, PMID 21565561, PMID 22005709, PMID 22281937, PMID 22464072, PMID 22590644, PMID 22617594, PMID 22742782, PMID 23215555, PMID 23613152, PMID 23711443, PMID 23712453, PMID 23914737, PMID 24135152, PMID 24207068, PMID 24252784, PMID 24388429, PMID 24656411, PMID 24785862, PMID 25004354, PMID 25111587, PMID 25479548, PMID 25682445
K12HD043494 (7), R01AI047040 (7), R01AI054843 (6), R56AI047040 (4), 2018 (1), 2023 (1), R01HL084410 (1), R01HL157157 (1), R33MH085901 (1), R34MH091314 (1), UL1TR000093 (1)