9 unknown, 8 completed, 7 recruiting, 1 active not recruiting. 7 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Unknown 3, Completed 2, Recruiting 2 |
| Phase 2 | 1 | Terminated 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Adrenal incidentaloma: new trials by email Literature Review of Adrenal incidentaloma trials Research Report on Adrenal incidentaloma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ultradian Steroid Rhythms in Adrenal Incidentalomas U-RYTHM system - Mild Autonomous Cortisol Secretion Adenoma, Non Secreting Adenoma | Not applicable | Recruiting | University Hospital, Bordeaux | 40 | 2026-04-15 | 2026-04-23 |
| IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion Intervention 1: Adrenalectomy, Intervention 2: Semaglutide - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 75 | 2026-03-05 | 2026-03-27 |
| Cardiovascular Complications After Adrenalectomy for Pheochromocytoma and Non-secreting Tumors adrenalectomy - Pheochromocytoma, Cardiovascular Complication | Recruiting | Central Hospital, Nancy, France | 522 | 2025-10-01 | 2026-10-22 | |
| Artificial Intelligence Used in Screening Adrenal Nodules None intervention - Adrenal Incidentalomas, Thoracic CT-scan | Recruiting | Peking University First Hospital | 600 | 2025-09-01 | 2025-09-30 | |
| CRISAL Study:Cancer Risk In Secreting Adrenal Lesions Adrenal Tumor, Adrenal Incidentaloma | Unknown | University of Roma La Sapienza | 300 | 2024-08-27 | 2024-08-30 | |
| Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study Cognitive function assessment; functional magnetic resonance imaging, laparoscopic adrenal surgery - Autonomous Cortisol Secretion, Adrenal Incidentaloma | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 62 | 2021-10-01 | 2022-05-02 | |
| China Adrenal Disease Registry Cushing Syndrome, Aldosteronism | Unknown | Shanghai Jiao Tong University School of Medicine | 2000 | 2021-06-01 | 2022-02-14 | |
| Association Between Stroke and Adrenal Incidentalomas Stroke, Adrenal Incidentaloma | Recruiting | Xuanwu Hospital, Beijing | 2 | 2021-04-01 | 2022-02-14 | |
| Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome Metarapone, Standardized antihypertensive therapy - Adrenal Incidentalomas, Cushing Syndrome | Phase 4 | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 50 | 2021-02-23 | 2025-01-30 |
| Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Spectral Photon Counting Computed Tomography (SPCCT), DECT (Dual Energy CT) - Diabetic Foot Ulcer, Coronary Artery Disease | Not applicable | Unknown | Hospices Civils de Lyon | 339 | 2021-01-29 | 2024-04-04 |
| The Prevalence and Characteristics of Adrenal Incidentaloma Prevalence, Adrenal Incidentaloma | Completed | Chongqing Medical University | 25356 | 2020-11-20 | 2022-08-10 | |
| Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism experimental group - Adrenal Incidentaloma, Subclinical Hypercortisolism | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 202 | 2020-04-01 | 2022-04-15 | |
| Natural History of NFAI: 10 Year Follow-up Results CT imaging - Adrenal Incidentaloma | Unknown | University Medical Centre Ljubljana | 65 | 2019-06-01 | 2020-11-05 | |
| Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations Adrenalectomy - Adrenal Incidentaloma, Hypercortisolism | Recruiting | University of Roma La Sapienza | 68 | 2019-01-02 | 2025-03-28 | |
| A Prospective Cohort Study for Patients With Adrenal Diseases Hormone study and Imaging study - Adrenal Adenoma, Cushing Syndrome | Enrolling by invitation | Seoul National University Hospital | 1500 | 2018-10-01 | 2020-03-18 | |
| Serum and Salivary Cortisol Assessment in Patients With Adrenal Incidentalomas and Healthy Controls 1 mg overnight dexamethasone suppression test - Adrenal Incidentaloma, Hypercortisolism | Completed | Copenhagen University Hospital, Rigshospitalet | 209 | 2016-11-24 | 2026-01-20 | |
| Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas adrenalectomy - Adrenal Incidentaloma, Subclinical Hypercortisolism | Not applicable | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 61 | 2016-09-29 | 2021-04-26 |
| Morbidity and Mortality in Autonomous Cortisol Secretion Adrenal Incidentaloma, Cortisol Overproduction | Completed | Region Skane | 4596 | 2015-09-15 | 2021-03-26 | |
| Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR - Adrenal Incidentalomas | Not applicable | Completed | University Hospital, Bordeaux | 78 | 2015-04-09 | 2023-07-20 |
| Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Adrenal Incidentaloma, Adrenocortical Carcinoma | Completed | University Medical Center Groningen | 807 | 2015-01-01 | 2026-01-07 |
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Cushing Syndrome (10) · Pheochromocytoma (5) · ACTH Syndrome, Ectopic (4) · Hyperaldosteronism (4) · Adrenal Gland Neoplasms (3) · Adrenal Cortex Neoplasms (2) · Adrenocortical Carcinoma (2) · Diabetes Mellitus (2) · Hypertension (2) · Obesity (2) · Adrenal Gland Diseases (1) · Adrenal Hyperplasia, Congenital (1) · Adrenal Insufficiency (1) · Alcoholism (1)
Endocrine System Diseases (14) · Adrenal Gland Diseases (13) · Neoplasms (12) · Adrenocortical Hyperfunction (11) · Endocrine Gland Neoplasms (7) · Neoplasms by Site (7) · Neoplasms by Histologic Type (6) · Nutritional and Metabolic Diseases (6) · Metabolic Diseases (5) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Nerve Tissue (5) · Neuroectodermal Tumors (5) · Neuroendocrine Tumors (5) · Paraganglioma (5) · Adrenal Cortex Diseases (4)
Adrenalectomy (4) · Observation (1) · Postmortem Imaging (1) · Surgical Procedures, Operative (1)
Seoul National University Hospital (2) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (2) · University Hospital, Bordeaux (2) · University of Roma La Sapienza (2) · Central Hospital, Nancy, France (1) · Chongqing Medical University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Haukeland University Hospital (1) · Hospices Civils de Lyon (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Istanbul University (1) · National Cancer Institute (NCI) (1) · Peking University First Hospital (1) · Region Skane (1)
China (6) · Italy (5) · France (4) · South Korea (3) · Germany (2) · United States (2) · Denmark (1) · Netherlands (1) · Norway (1) · Slovenia (1) · Sweden (1) · Turkey (Türkiye) (1)
A.F. Muller, MD, PhD (1) · Andrea M Isidori, MD, PHD (1) · B. Havekes, MD, PhD (1) · Dalong Zhu, MD,PhD (1) · Dhaval T Patel, M.D. (1) · E Buitenwerf, MD (1) · E. Donga, MD (1) · G.D. Valk, MD, PhD (1) · Guido Di Dalmazi, MD (1) · H. de Boer, MD, PhD (1)
PMID 19649755, PMID 25968622, PMID 27390021, PMID 28685511, PMID 29189215, PMID 31694993, PMID 34029490, PMID 35137142, PMID 35533704, PMID 35721734, PMID 36095315, PMID 36263685, PMID 36800277, PMID 40373786, PMID 41572809, PMID 41811595, PMID 41940913
K23DK142038 (1)