8 recruiting, 6 not yet recruiting, 2 enrolling by invitation, 1 completed. 5 Not applicable, 3 Phase 2, 1 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Not yet recruiting 2, Recruiting 2, Unknown 1 |
| Phase 2 | 3 | Recruiting 2, Withdrawn 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Enrolling by invitation 1 |
Follow HFrEF - Heart Failure With Reduced Ejection Fraction: new trials by email Literature Review of HFrEF - Heart Failure With Reduced Ejection Fraction trials Research Report on HFrEF - Heart Failure With Reduced Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Coffee Use, Physical Activity and Symptomatic Ventricular Arrhythmias in Patients With Left Ventricular Dysfunction and an ICD Questionnaire - HFrEF - Heart Failure With Reduced Ejection Fraction, HFmrEF | Not yet recruiting | Jean-Benoît Le Polain de Waroux | 170 | 2026-10-01 | 2026-09-17 | |
| ALP-1 Continuous Intravenous Infusion to Maintain Clinical Stability in Advanced Heart Failure Alprostadil - End Stage Cardiac Failure, HFrEF - Heart Failure With Reduced Ejection Fraction | Phase 3 | Not yet recruiting | Biopeutics Co., Ltd | 600 | 2026-10-01 | 2025-12-15 |
| Intermediate Outcomes of HFrEF Patients on Guideline-Directed Medical Therapy Heart Failure With Reduced Ejection Fraction, HFrEF - Heart Failure With Reduced Ejection Fraction | Not yet recruiting | Assiut University | 250 | 2026-09-26 | 2026-09-30 | |
| Wearable Device-Assisted Remote Management in Atrial Fibrillation Complicated by Heart Failure: WARM-HF Trial Wearable Device-Assisted Intervention - HFrEF - Heart Failure With Reduced Ejection Fraction, AF - Atrial Fibrillation | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 400 | 2026-08-01 | 2026-06-29 |
| Guideline Implementation and Quality of Care Evaluation in Patients With Heart Failure and Reduced Ejection Fraction (HFrEF) HFrEF - Heart Failure With Reduced Ejection Fraction, Guideline Adherence | Recruiting | Jasper Brugts MD PhD | 1500 | 2026-07-07 | 2026-10-13 | |
| Impact of Barostimulation on Hemodynamics in Adults With Heart Failure Baroreflex Activation Therapy - HFrEF - Heart Failure With Reduced Ejection Fraction | Not applicable | Recruiting | Columbia University | 58 | 2026-03-30 | 2026-06-29 |
| Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) beta blockers, StudyU Application - HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 5 | 2026-02-10 | 2026-02-19 |
| Swedish Cardiac And Renal Failure Study-1 Eplerenone - HFrEF - Heart Failure With Reduced Ejection Fraction, Chronic Kidney Disease | Phase 2 | Recruiting | Karolinska Institutet | 40 | 2026-02-01 | 2026-02-24 |
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension JK07 - HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Withdrawn | Salubris Biotherapeutics Inc | 2025-12-15 | 2026-05-15 | |
| Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation | Recruiting | Centre Hospitalier de Corbie | 62 | 2025-11-25 | 2025-12-16 | |
| Vsling™ III: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients with Heart Failure Vsling - HFrEF - Heart Failure with Reduced Ejection Fraction | Not applicable | Not yet recruiting | Cardiac Success | 10 | 2025-08-01 | 2025-01-03 |
| Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences Diabetes Mellitus Type 2, Heart Failure | Recruiting | University of Leeds | 600 | 2025-02-26 | 2025-02-28 | |
| Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction Vericiguat Oral Tablet [Verquvo], Prescription Drugs - HFrEF - Heart Failure With Reduced Ejection Fraction, Myocardial Infarction (MI) | Not yet recruiting | Qilu Hospital of Shandong University | 210 | 2025-01-01 | 2024-12-04 | |
| AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor 15-minutes of sitting during COR ECG Acquistion - Ventricular Ejection Fraction, LVF | Recruiting | Peerbridge Health, Inc | 2000 | 2024-11-21 | 2026-06-01 | |
| COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C - Cardiopulmonary Failure, Myocardial Infarction (MI) | Enrolling by invitation | Peerbridge Health, Inc | 15000 | 2024-11-16 | 2025-01-08 | |
| Electronic Medical Record Alerts to Optimize Medical Therapy in Heart Failure and Reduced Ejection Fraction EMR alert - HFrEF - Heart Failure With Reduced Ejection Fraction | Not applicable | Unknown | Instituto Cardiovascular de Buenos Aires | 240 | 2024-01-15 | 2023-12-12 |
| Effect of Vericiguat on cardiAc Remodeling in Patients With Heart faiLure and Reduced Ejection fractioN (HFrEF): A Prospective sTudy usIng NOvel Echocardiographic Imaging Techniques (VALENTINO) HFrEF - Heart Failure With Reduced Ejection Fraction | Completed | Chinese University of Hong Kong | 40 | 2023-10-09 | 2026-03-16 | |
| Eccentric Muscle Training in Cardiac Rehabilitation eccentric bike training, eccentric overload training, aerobic treadmill training - Strength Training Effects, HFrEF - Heart Failure With Reduced Ejection Fraction | Not applicable | Recruiting | University Hospital, Antwerp | 3 | 2023-01-20 | 2026-06-09 |
| Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction SRD-001, Placebo - Congestive Heart Failure, Heart Failure, Systolic | Phase 1 / Phase 2 | Recruiting | Sardocor Corp. | 57 | 2021-09-23 | 2024-03-26 |
Heart Failure (8) · Heart Failure, Systolic (3) · Myocardial Infarction (3) · Arrhythmias, Cardiac (2) · Atrial Fibrillation (2) · Atrial Remodeling (2) · Syncope (2) · Ventricular Dysfunction, Left (2) · Alzheimer Disease (1) · Cardiac Output, Low (1) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Cardiotoxicity (1) · Diabetes Mellitus, Type 2 (1) · Fibromatosis, Gingival, 2 (1)
Cardiovascular Diseases (10) · Heart Diseases (9) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Vascular Diseases (4) · Ischemia (3) · Necrosis (3) · Nervous System Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Consciousness Disorders (2) · Infarction (2) · Metabolic Diseases (2) · Myocardial Ischemia (2) · Neurobehavioral Manifestations (2) · Neurologic Manifestations (2)
Adrenergic beta-Antagonists (1) · Alprostadil (1) · Eplerenone (1) · Prescription Drugs (1) · Surveys and Questionnaires (1) · vericiguat (1)
Peerbridge Health, Inc (2) · Assiut University (1) · Beijing Anzhen Hospital (1) · Biopeutics Co., Ltd (1) · Cardiac Success (1) · Centre Hospitalier de Corbie (1) · Chinese University of Hong Kong (1) · Columbia University (1) · Instituto Cardiovascular de Buenos Aires (1) · Jasper Brugts MD PhD (1) · Jean-Benoît Le Polain de Waroux (1) · Karolinska Institutet (1) · Qilu Hospital of Shandong University (1) · Salubris Biotherapeutics Inc (1) · Sardocor Corp. (1)
United States (6) · Belgium (2) · Austria (1) · China (1) · France (1) · Hong Kong (1) · Netherlands (1) · Sweden (1) · United Kingdom (1)
Sandeep Gulati, PhD (2) · Alex PW Lee, Professor (1) · Andrea Natale, MD (1) · Brian Kolski, MD (1) · Daniel Bensimhon, MD (1) · Francesco Orlando, MD (1) · Frank Mazzola, MD (1) · Johanna P Contreras, MD (1) · Krister Lindmark, MD, PhD (1) · Martin Huelsmann, MD (1) · Nir Uriel, MD (1) · Noemi Pavo, MD PhD (1) · Panpan Hao, MD, PhD (1) · Parag Goyal, MD, MSc (1)
2025 (1)