12 recruiting, 6 completed, 5 enrolling by invitation, 3 not yet recruiting. 10 Not applicable, 6 Phase 2, 3 Phase 3, 2 Phase 1, 1 Phase 4.
Follow HFpEF - Heart Failure With Preserved Ejection Fraction: new trials by email Literature Review of HFpEF - Heart Failure With Preserved Ejection Fraction trials Research Report on HFpEF - Heart Failure With Preserved Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure Exercise training - HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation | Not applicable | Recruiting | Technical University of Munich | 40 | 2027-02-01 | 2026-09-18 |
| Finerenone in Patients Undergoing Transcatheter Aortic Valve Implantation With Heart Failure Finerenone, Placebo - HFpEF - Heart Failure With Preserved Ejection Fraction, TAVI(Transcatheter Aortic Valve Implantation) | Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2832 | 2026-10-09 | 2026-10-16 |
| The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial) Tamibarotene, Placebo - HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Not yet recruiting | Nagoya University | 90 | 2026-10-01 | 2026-10-02 |
| Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF) Exercise-Based Cardiac Rehabilitation, Guideline-Directed Medical Therapy - HF - Heart Failure, HFpEF - Heart Failure With Preserved Ejection Fraction | Not applicable | Not yet recruiting | Fundación para la Investigación del Hospital Clínico de Valencia | 390 | 2026-09-01 | 2026-07-27 |
| Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction High-intensity interval training - HFpEF - Heart Failure With Preserved Ejection Fraction | Not applicable | Recruiting | Peking University Third Hospital | 192 | 2026-08-10 | 2026-10-21 |
| Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) Placebo (matching), Beta-blockers - Heart Failure, HFpEF | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 240 | 2026-02-02 | 2026-10-16 |
| Can Tiny Bubbles Offer an Alternative to Catheters for Assessing Pressures Inside the Heart? Investigating Ultrasound Contrast Agents as Pressure Sensors Against Gold Standard Catheter Pressures in Cardiac Catheterisation Patients. Contrast Echocardiography - HFpEF - Heart Failure With Preserved Ejection Fraction, Cardiac Catheterisation | Not applicable | Recruiting | King's College London | 10 | 2026-02-01 | 2026-02-18 |
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension JK07 - HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Withdrawn | Salubris Biotherapeutics Inc | 2025-12-15 | 2026-05-15 | |
| US Benchmarking Clinical Study HFpEF - Heart Failure With Preserved Ejection Fraction, HFmrEF | Recruiting | eMyosound SAS | 150 | 2025-09-16 | 2025-10-20 | |
| Testing the CHAT Program for Patients With Heart Failure Conversations Helpful for Awareness of Illness Trajectory (CHAT) Intervention, Standard of Care (SOC) - HFpEF - Heart Failure With Preserved Ejection Fraction | Not applicable | Completed | Weill Medical College of Cornell University | 50 | 2025-07-31 | 2026-09-24 |
| MOVE-HF MOtivating Physical Activity With BehaVioral Economics in Heart Failure With Preserved Ejection Fraction Gamification plus social incentive, Gamification plus competition - HFpEF - Heart Failure With Preserved Ejection Fraction | Not applicable | Recruiting | University of Pennsylvania | 270 | 2025-06-05 | 2026-10-06 |
| The Safety and Efficacy of Pulsed Field Ablation for Patients With Persistent Atrial Fibrillation Comorbid With HFpEF. pulsed field ablation, antiarrhythmic drug - Cardiovascular Diseases, Heart Failure | Not applicable | Enrolling by invitation | Affiliated Hospital of Nantong University | 158 | 2025-06-01 | 2025-07-22 |
| CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation Dapagliflozin tablet, Placebo Tablet - Fontan Circulation, Single Ventricle Heart Disease | Phase 2 | Recruiting | Mayo Clinic | 27 | 2025-05-16 | 2026-05-06 |
| Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences Diabetes Mellitus Type 2, Heart Failure | Recruiting | University of Leeds | 600 | 2025-02-26 | 2025-02-28 | |
| Tailored Exercise Training Study Among Adults With HFpEF Moderate-intensity continuous training (MCT), Resistance training, Weight loss - HFpEF - Heart Failure With Preserved Ejection Fraction, Diabetic Cardiomyopathies | Phase 2 / Phase 3 | Recruiting | University of Texas Southwestern Medical Center | 120 | 2025-02-18 | 2025-10-31 |
| Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data Semaglutide, Placebo - Diabetes Mellitus, Type 2, HFpEF - Heart Failure With Preserved Ejection Fraction | Completed | Brigham and Women's Hospital | 58387 | 2025-01-14 | 2026-01-30 | |
| Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction Tirzepatide, Semaglutide - Diabetes Mellitus, Type 2, HFpEF - Heart Failure With Preserved Ejection Fraction | Completed | Brigham and Women's Hospital | 28118 | 2025-01-14 | 2026-01-30 | |
| Serum IGF1 on Female HFpEF Patients HFpEF - Heart Failure With Preserved Ejection Fraction | Enrolling by invitation | The University of Hong Kong-Shenzhen Hospital | 120 | 2025-01-01 | 2025-06-11 | |
| Atrial Fibrillation with Heart Failure with Preserved Ejection Fraction: Treatment Strategies-Catheter Ablation Vs. Anti-Atrial Arrhythmia Drugs Catheter ablation of atrial fibrillation - HFpEF - Heart Failure with Preserved Ejection Fraction, Atrial Fibrillation (AF) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 304 | 2024-12-16 | 2024-12-18 |
| AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor 15-minutes of sitting during COR ECG Acquistion - Ventricular Ejection Fraction, LVF | Recruiting | Peerbridge Health, Inc | 2000 | 2024-11-21 | 2026-06-01 |
Showing 20 of 31. Sign in to see all of them.
Heart Failure (8) · Atrial Fibrillation (6) · Diabetes Mellitus, Type 2 (4) · Arrhythmias, Cardiac (2) · Atrial Remodeling (2) · Diabetic Cardiomyopathies (2) · Hypertension, Pulmonary (2) · Myocardial Infarction (2) · Syncope (2) · Ventricular Dysfunction, Left (2) · Amyloid Neuropathies, Familial (1) · Cardiac Output, Low (1) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Cardiotoxicity (1)
Cardiovascular Diseases (15) · Heart Diseases (14) · Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (7) · Metabolic Diseases (6) · Nutritional and Metabolic Diseases (6) · Arrhythmias, Cardiac (5) · Diabetes Mellitus (5) · Endocrine System Diseases (5) · Glucose Metabolism Disorders (4) · Vascular Diseases (4) · Cardiomyopathies (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Nervous System Diseases (3) · Pathological Conditions, Anatomical (3)
Adrenergic beta-Antagonists (2) · Colchicine (2) · Metoprolol (2) · semaglutide (2) · Anti-Arrhythmia Agents (1) · Atenolol (1) · Bisoprolol (1) · Calcium Channel Blockers (1) · Carvedilol (1) · Catheter Ablation (1) · Deprescriptions (1) · Diltiazem (1) · Exercise (1) · High-Intensity Interval Training (1) · Methods (1)
Brigham and Women's Hospital (2) · Peerbridge Health, Inc (2) · The First Affiliated Hospital with Nanjing Medical University (2) · Weill Medical College of Cornell University (2) · Affiliated Hospital of Nantong University (1) · Amsterdam UMC, location VUmc (1) · Cairo University (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · I.M. Sechenov First Moscow State Medical University (1) · Imbria Pharmaceuticals, Inc. (1) · KU Leuven (1) · King's College London (1) · Mayo Clinic (1) · Nagoya University (1) · Peking University Third Hospital (1)
United States (13) · China (7) · United Kingdom (3) · Netherlands (2) · Belgium (1) · Egypt (1) · Germany (1) · Japan (1) · Russia (1) · Spain (1)
Parag Goyal, MD, MSc (2) · Sandeep Gulati, PhD (2) · Shirley Wang, PhD, ScM (2) · Ahmed Kamal, MD in Cardiology (1) · Alexander Fanaroff, MD, MHS (1) · Anastasia Shchendrygina (1) · Andrea Natale, MD (1) · Andrew Ambrosy, MD, MPH (1) · Arash Yavari, BSc, MBBS, DPhil (1) · Brian Kolski, MD (1) · Bunny Pozehl, PhD (1) · Daniel Bensimhon, MD (1) · Frank Mazzola, MD (1) · Johanna P Contreras, MD (1)
PMID 40886075, PMID 28993402, PMID 31507065, PMID 32449907, PMID 33560320, PMID 34379370, PMID 36220507, PMID 36758740, PMID 37461163, PMID 37565370, PMID 37586845, PMID 41410037
R01AG091005 (1), R01HL174691 (1), R21AG077092 (1)