173 completed, 113 unknown, 11 recruiting, 10 not yet recruiting. 334 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 334 | Completed 173, Unknown 113, Recruiting 11, Not yet recruiting 10, Terminated 9, Withdrawn 9, Active not recruiting 7, Enrolling by invitation 2 |
Follow Hepatitis B: new trials by email Literature Review of Hepatitis B trials Research Report on Hepatitis B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus | Phase 4 | Not yet recruiting | Eunice Dube | 2140 | 2027-01-30 | 2026-07-30 |
| Combating Related Epidemics in HCV Cepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2 - HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV) | Phase 4 | Not yet recruiting | Duke University | 1280 | 2027-01-20 | 2026-10-15 |
| B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants Bepirovirsen - Hepatitis B | Phase 4 | Not yet recruiting | GlaxoSmithKline | 303 | 2026-12-03 | 2026-11-02 |
| Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Tolerant Chronic Hepatitis B Entecavir, Entecavir + Pegylated interferon α-2b - Hepatitis B Virus Infection, Children | Phase 4 | Not yet recruiting | Qing-Lei Zeng | 80 | 2026-01-11 | 2026-01-16 |
| Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Active Chronic Hepatitis B Entecavir, Entecavir + Pegylated interferon α-2b - Hepatitis B Virus Infection, Children | Phase 4 | Not yet recruiting | Qing-Lei Zeng | 60 | 2026-01-11 | 2026-01-16 |
| Strengthening Hepatitis B Screening, Linkage to Care and Long-Term Monitoring in Phichit Province, Thailand: A Birth Bohort Approach Tenofovir Alafenamide (TAF), Community-Based Support, Simplified WHO 2024 Criteria - Chronic Hepatitis B, Hepatitis B Virus Infection | Phase 4 | Not yet recruiting | The Task Force for Global Health | 6000 | 2026-01-01 | 2025-12-02 |
| Prospective Cohort Study on PEG-IFN-α-2b in Improving Clinical Cure Rate of Pediatric Patients With Chronic Hepatitis B Peginterferon alfa-2b Injection - HBV, Chronic Hepatitis B Virus | Phase 4 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 113 | 2026-01-01 | 2025-11-17 |
| Comparison of Viral Suppression With 0.5 mg and 1.0 mg Daily Doses of Entecavir in Decompensated HBV Cirrhosis of Liver Entecavir - Hepatitis B | Phase 4 | Recruiting | Bangladesh Medical University | 48 | 2026-01-01 | 2026-09-11 |
| Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors Entecavir, HBIG, EVLP UV Light Treatment - Hepatitis B Virus (HBV), Lung Transplant Recipient | Phase 4 | Recruiting | University Health Network, Toronto | 20 | 2025-09-24 | 2025-11-17 |
| Clinical Efficacy of Pegylated Interferon Alpha-2b Combined With Nucleos(t)Ide Analogues in the Treatment of Chronic Hepatitis B Patients Peg-IFN α-2b combined with NAs - Metabolic Dysfunction-Associated Steatotic Liver Disease, Chronic Hepatitis B | Phase 4 | Not yet recruiting | Shenzhen Third People's Hospital | 830 | 2025-08-15 | 2025-07-17 |
| Pegylated Interferon Alfa-2b in Reducing Relapse Rates After Nucleos(t)ide Analogue Withdrawal in HBeAg-negative CHB Patients with Low Level HBsAg PegIFN alfa-2b, PegIFN alfa-2b and NUC - Chronic Hepatitis B | Phase 4 | Not yet recruiting | Huashan Hospital | 360 | 2025-04-01 | 2025-03-28 |
| TAF in Early/Middle Pregnancy With CHB TAF, TDF - Hepatitis B Infection, Pregnant Women | Phase 4 | Enrolling by invitation | The Third Affiliated Hospital of Guangzhou Medical University | 816 | 2025-03-31 | 2026-06-25 |
| TAF vs TDF During the Pregancy TAF - Hepatitis B Virus Infection; Pregnant Women | Phase 4 | Enrolling by invitation | The Third Affiliated Hospital of Guangzhou Medical University | 210 | 2024-12-27 | 2026-10-16 |
| ASC22 Combined With Peg-IFNa in Achieving Functional Cure in Patients With Chronic Hepatitis B Virus Infection Anti-PD-L1 antibody (ASC22), Nucleotide analogs, Peg-IFNα - Chronic Hepatitis b | Phase 4 | Recruiting | The Second Affiliated Hospital of Chongqing Medical University | 120 | 2024-05-21 | 2026-09-01 |
| SGLT2i to Prevent of Liver Complications in Patients With CHB and Diabetes Mellitus Dapagliflozin 10mg Tab, Placebo 10mg Tab - Chronic Hepatitis B | Phase 4 | Recruiting | Chinese University of Hong Kong | 412 | 2024-03-26 | 2026-03-18 |
| UHN Inpatient Hepatitis C & B Screening Quality Improvement - Hepatitis C, Hepatitis B | Phase 4 | Unknown | Jordan Feld | 2920 | 2024-02-01 | 2024-02-08 |
| Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B Complicated With Nonalcoholic Fatty Liver Disease（OCEAN PROJECT） Peg-Interferon α - Nonalcoholic Fatty Liver Disease, Chronic Hepatitis b | Phase 4 | Recruiting | First Affiliated Hospital of Wenzhou Medical University | 1500 | 2024-01-01 | 2024-04-16 |
| National Liver Cancer Screening Trial GALAD, Liver Ultrasound with or without AFP - Carcinoma, Hepatocellular, Liver Cancer | Phase 4 | Recruiting | University of Texas Southwestern Medical Center | 5500 | 2023-12-26 | 2026-09-25 |
| Efficacy and Safety of Switching to Vemliver From Entecavir in Chronic Hepatitis B Patients Previously Treated With Entecavir Vemliver tablet, Baracross Tablet - Hepatitis B, Chronic | Phase 4 | Completed | Daewoong Pharmaceutical Co. LTD. | 196 | 2023-08-28 | 2025-03-18 |
| The COMBAT HBV Feasibility Trial Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine, Placebo - Hepatitis B, Vertical Transmission of Infectious Disease | Phase 4 | Completed | University of North Carolina, Chapel Hill | 317 | 2023-08-17 | 2026-02-19 |
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Hepatitis B, Chronic (190) · Liver Cirrhosis (13) · Diphtheria (12) · Tetanus (12) · Haemophilus Infections (10) · Hepatitis A (9) · Carcinoma, Hepatocellular (8) · Fibrosis (8) · Hepatitis (8) · HIV Infections (7) · Whooping Cough (7) · Poliomyelitis (5) · Hepatitis C (4) · Bronchiolitis Obliterans Syndrome (3)
Blood-Borne Infections (334) · Communicable Diseases (334) · Hepadnaviridae Infections (334) · DNA Virus Infections (333) · Digestive System Diseases (333) · Hepatitis, Viral, Human (333) · Virus Diseases (333) · Liver Diseases (332) · Infections (331) · Hepatitis (326) · Pathologic Processes (205) · Pathological Conditions, Signs and Symptoms (205) · Disease Attributes (196) · Chronic Disease (191) · Hepatitis, Chronic (190)
entecavir (70) · Tenofovir (49) · peginterferon alfa-2a (41) · Lamivudine (32) · Telbivudine (25) · Hepatitis B Vaccines (23) · adefovir dipivoxil (23) · adefovir (22) · tenofovir alafenamide (20) · Engerix-B (15) · clevudine (9) · twinrix (8) · Emtricitabine (7) · peginterferon alfa-2b (7) · Blood Specimen Collection (6)
GlaxoSmithKline (43) · Hoffmann-La Roche (16) · Third Affiliated Hospital, Sun Yat-Sen University (14) · Nanfang Hospital, Southern Medical University (10) · National Taiwan University Hospital (10) · Bukwang Pharmaceutical (8) · Yonsei University (7) · Novartis Pharmaceuticals (6) · Asian-Pacific Alliance of Liver Disease, Beijing (5) · Beijing Ditan Hospital (5) · Korea University (5) · Shanxi Medical University (5) · University of North Carolina, Chapel Hill (5) · Asan Medical Center (4) · Beijing 302 Hospital (4)
China (102) · South Korea (50) · Taiwan (29) · United States (24) · Germany (20) · Canada (18) · Thailand (15) · Belgium (12) · Hong Kong (11) · Australia (7) · India (7) · Netherlands (7) · Spain (7) · Brazil (6) · Italy (6)
Jun Cheng, M.D. (5) · Calvin Q Pan, MD (3) · Hong You, Doctor (3) · Jinlin Hou, MD (3) · Jun Yong Park, M.D (3) · Pei-Jer Chen, M.D., Ph.D. (3) · Raman Rao, MD (3) · Romanee Chaiwarith, MD (3) · Sang Hoon Ahn, M.D.Ph.D (3) · Suping Wang (3) · Suping Wang, PhD (3)
PMID 24915612, PMID 28404091, PMID 28404092, PMID 15470215, PMID 19187608, PMID 21182232, PMID 22436845, PMID 23046671, PMID 23518903, PMID 28427875, PMID 29405329, PMID 32710245, PMID 15014185, PMID 19052126, PMID 19729084, PMID 20009522, PMID 20049753, PMID 21366801, PMID 22045673, PMID 22508412, PMID 22777097, PMID 23732904, PMID 24954675, PMID 25348661, PMID 29696665, PMID 30576085, PMID 30689258, PMID 33460002, PMID 34843068, PMID 35599306, PMID 39373164, PMID 40390028, PMID 42349783, PMID 10051494, PMID 10613747, PMID 10618544, PMID 11850253, PMID 12019083, PMID 12606735, PMID 12865912, PMID 14697813, PMID 15565615, PMID 15749627, PMID 15750456, PMID 15985009, PMID 15987917, PMID 16164651, PMID 16391218, PMID 16525137, PMID 16525138
2014 (2), 2015 (2), 2009 (1), 2016 (1), 2019 (1), R01DA014502 (1), U01AI195193 (1), U24CA086368 (1)