168 completed, 46 terminated, 25 unknown, 12 withdrawn. 81 Phase 2, 76 Phase 3, 35 Phase 4, 29 Phase 1, 12 Not applicable.
Follow peginterferon alfa-2b: new trials by email Literature Review of peginterferon alfa-2b trials Research Report on peginterferon alfa-2b
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ropeginterferon Alfa-2b for the Treatment of Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes and Chronic Myelomonocytic Leukemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Atypical Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia | Phase 2 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 35 | 2026-09-29 | 2026-05-06 |
| Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy SV-BR-1-GM Vaccine, Cyclophosphamide, Pembrolizumab - Brain Metastases, Leptomeningeal Metastasis | Phase 1 | Withdrawn | Medical College of Wisconsin | 2026-06-15 | 2026-06-17 | |
| Efficacy and Safety of Pegylated Interferon Alpha-2β in Patients With Hepatitis B-related Hepatocellular Carcinoma After Radical Resection Peginterferon alfa-2b, TDF, TAF - Hepatocellular Carcinoma, HEPATITIS B CHRONIC | Early Phase 1 | Not yet recruiting | Ningbo No.2 Hospital | 156 | 2026-03-31 | 2026-04-28 |
| Prospective Cohort Study on PEG-IFN-α-2b in Improving Clinical Cure Rate of Pediatric Patients With Chronic Hepatitis B Peginterferon alfa-2b Injection - HBV, Chronic Hepatitis B Virus | Phase 4 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 113 | 2026-01-01 | 2025-11-17 |
| Clinical Study of Antiviral Therapy Combined With Novel Immunotherapy for CHB in Adults Peg interferon alfa-2b - Chronic Hepatitis b, Immunotherapy | Not applicable | Enrolling by invitation | Beijing Ditan Hospital | 180 | 2023-12-01 | 2025-01-15 |
| Functional Cure of Hepatitis B in HIV/HBV Co-infected Patients Peginterferon alfa-2b Injection - AIDS, Hepatitis B | Recruiting | Guangzhou 8th People's Hospital | 60 | 2023-08-02 | 2023-08-14 | |
| Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in Adult Essential Thrombocythemia Recombinant Interferon Alpha, Pegylated interferon alfa-2b - Essential Thrombocytopenia | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 194 | 2022-06-01 | 2024-07-03 |
| Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients Peginterferon Alfa-2B, Nucleoside Analogs - Hepatitis B, Chronic | Phase 4 | Recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 5000 | 2022-01-08 | 2025-05-01 |
| Peginterferon Alpha-2b Therapy in Chronic Hepatitis Patients With Normal ALT Level and Low Viremia Peginterferon alpha-2b, Nucleotide Analog, pulse peginterferon alpha-2b - Chronic Hepatitis B Patients With a Normal ALT Level and Low Viremia | Phase 1 / Phase 2 | Unknown | Fuzhou General Hospital | 300 | 2021-12-10 | 2022-01-24 |
| Peg-Interferon Alpha 2b Combined With Two Intravenous Broadly HIV-1 Neutralizing Antibodies 3BNC117 and 10-1074 (BEAT-2) Pegylated Interferon alpha 2b (peg-IFN-α2b), 3BNC117 + 10-1074 - HIV, HIV/AIDS | Phase 1 | Unknown | Luis Montaner | 15 | 2020-06-18 | 2021-06-25 |
| Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in Childhood and Adolescent Essential Thrombocythemia Recombinant Interferon Alpha, Pegylated interferon alfa-2b - Essential Thrombocytopenia | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 40 | 2020-01-10 | 2024-07-03 |
| A Study of Peginterferon Alfa-2b Combined With TDF in Patients With Chronic Hepatitis B Peginterferon alfa-2b injection, TDF - Chronic Hepatitis B | Phase 3 | Completed | Xiamen Amoytop Biotech Co., Ltd. | 475 | 2019-12-04 | 2024-03-05 |
| A Prospective Study to Evaluate Peginterferon in Reducing the Incidence of HCC in CHB Patients Peginterferon alfa-2b Injection, Nucleos (t) ide Analogue, Nucleos(t)ide analogue - Chronic Hepatitis B, Intermediate to High Risk of HCC | Not applicable | Unknown | Qing XIe | 267 | 2019-07-03 | 2023-05-25 |
| Optimized Treatment of Peginterferon Alfa 2a/2b in Anti-virus Treatment Naive Patients With HBV Related Liver Fibrosis Tenofovir Disoproxil Fumarate, Peginterferon Alfa-2a, Peginterferon Alfa-2b - Hepatitis B, Liver Fibrosis | Not applicable | Unknown | Third Affiliated Hospital, Sun Yat-Sen University | 120 | 2019-02-01 | 2019-04-19 |
| Optimized Treatment of Peginterferon Alfa 2a/2b in Treatment Experienced Patients With HBV Related Liver Fibrosis Tenofovir Disoproxil Fumarate, Peginterferon Alfa-2a, Peginterferon Alfa-2b - Hepatitis B, Liver Fibrosis | Not applicable | Unknown | Third Affiliated Hospital, Sun Yat-Sen University | 100 | 2019-02-01 | 2019-05-22 |
| Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-Intron Pembrolizumab, Sylatron - Advanced Cholangiocarcinoma | Phase 2 | Terminated | Aiwu Ruth He, MD | 4 | 2017-07-05 | 2022-02-16 |
| Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer Autologous Monocytes + ACTIMMUNE + SYLATRON - Fallopian Tube Cancer, Ovarian Cancer | Phase 1 | Terminated | National Cancer Institute (NCI) | 18 | 2017-02-08 | 2026-01-08 |
| Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Belinostat, Zidovudine, Interferon-Alfa-2b - Adult T-cell Leukemia-Lymphoma, ATLL | Phase 2 | Completed | University of Miami | 15 | 2016-12-12 | 2026-03-10 |
| The Optimizing Treatment of Peginterferon (PEG IFN) Alpha in Chronic Hepatitis B Virus Patients With Low Level HBsAg peginterferon alfa - Chronic Hepatitis B | Phase 4 | Unknown | Third Affiliated Hospital, Sun Yat-Sen University | 200 | 2016-08-01 | 2018-05-22 |
| HBsAg Loss/Seroconversion in Low Replicative Chronic Hepatitis B Virus(HBV) Infection Patients peginterferon alfa - Chronic Hepatitis B | Phase 4 | Unknown | Third Affiliated Hospital, Sun Yat-Sen University | 200 | 2016-08-01 | 2018-05-22 |
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Hepatitis C, Chronic (112) · Hepatitis C (76) · Hepatitis B, Chronic (18) · Melanoma (16) · HIV Infections (13) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (11) · Hepatitis B (10) · Liver Cirrhosis (9) · Carcinoma, Renal Cell (6) · Fibrosis (5) · Acquired Immunodeficiency Syndrome (4) · Kidney Neoplasms (4) · Carcinoma, Hepatocellular (3) · Coinfection (3) · Hepatitis (3)
Merck Sharp & Dohme LLC (99) · M.D. Anderson Cancer Center (9) · Third Affiliated Hospital, Sun Yat-Sen University (7) · Hoffmann-La Roche (5) · National Cancer Institute (NCI) (5) · Tanabe Pharma Corporation (5) · National Institute of Allergy and Infectious Diseases (NIAID) (4) · Xiamen Amoytop Biotech Co., Ltd. (4) · ANRS, Emerging Infectious Diseases (3) · Schering-Plough (3) · Weill Medical College of Cornell University (3) · Bausch Health Americas, Inc. (2) · Biocad (2) · Biolex Therapeutics, Inc. (2) · Emory University (2)
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Fumitaka Suzuki, MD (3) · Liang Peng, Doctor (3) · Eric Bellissant, MD, PhD (2) · Jorge E Cortes, MD (2) · Kazuoki Kondo, MD (2) · Lei Zhang, MD (2) · Ralph T. Doyle (2) · Rongfeng Fu (2) · Wen-Jen Hwu, MD, PhD (2) · Adam I Riker, MD (1) · Aiwu R. He, MD PhD (1) · Albert S Cornelius, MD (1) · Alberto Pappo, MD (1)
PMID 26947564, PMID 20189674, PMID 22239511, PMID 22626609, PMID 24329937, PMID 25196718, PMID 26936417, PMID 12419754, PMID 15316341, PMID 16544259, PMID 16987047, PMID 17147494, PMID 17302380, PMID 17721093, PMID 17875007, PMID 17894303, PMID 17894323, PMID 17943989, PMID 18184077, PMID 18501079, PMID 19594300, PMID 19625712, PMID 19797971, PMID 19898214, PMID 20458844, PMID 20509027, PMID 20677940, PMID 20683847, PMID 20684729, PMID 20692693, PMID 20938912, PMID 21056496, PMID 21064034, PMID 21079746, PMID 21237227, PMID 21419770, PMID 21431345, PMID 21449783, PMID 21449784, PMID 21488082, PMID 21784046, PMID 21827730, PMID 21836471, PMID 21871496, PMID 21911884, PMID 21921725, PMID 22239509, PMID 22331604, PMID 22387529, PMID 22585729
2004 (2), 2009 (2), 2014 (2), 2005 (1), N01CM62202 (1), P01CA128115 (1), P30CA016672 (1), P30CA022453 (1), P30CA023108 (1), P30CA060553 (1), P30CA093373 (1), P50CA083639 (1), R01AI049141 (1), R01AT007297 (1), R21CA122270 (1)