56 completed, 13 unknown, 4 terminated, 4 withdrawn. 26 Phase 4, 17 Phase 3, 15 Phase 2, 8 Phase 1, 7 Not applicable.
Follow adefovir dipivoxil: new trials by email Literature Review of adefovir dipivoxil trials Research Report on adefovir dipivoxil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Drug Transporter Interaction Study PHENTRA_2015_KPUK pitavastatin, Metformin, digoxin - Healthy | Phase 4 | Completed | University of Cologne | 24 | 2016-04-01 | 2019-09-10 |
| EFFORT Further Extension Study Telbivudine, Adefovir dipivoxil, off-treatment follow-up - Hepatitis B, Chronic | Phase 4 | Unknown | Nanfang Hospital, Southern Medical University | 130 | 2015-04-01 | 2016-07-07 |
| Emtricitabine Plus Adefovir Dipivoxil for Naive Chinese HBV Related Cirrhosis Patients Emtricitabine plus adefovir dipivoxil - Hepatitis B, Chronic, Fibrosis | Phase 4 | Unknown | Asian-Pacific Alliance of Liver Disease, Beijing | 400 | 2015-01-01 | 2014-12-30 |
| A Prospective Clinical Trial in Chronic Hepatitis B Patients NAs (Nucleotides or Nucleosides) Experienced (Anchor Study) Y peginterferon alfa-2b, Granulocyte-macrophage colony stimulating factor, Entecavir and or adefovir dipivoxil - Hepatitis B, Chronic | Phase 3 | Unknown | Tongji Hospital | 300 | 2014-10-01 | 2016-08-15 |
| The Safety and Dose-range Study of Metacavir Enteric-coated Capsules in Patients With Chronic Hepatitis B Metacavir Enteric-coated Capsules 80mg, Metacavir Enteric-coated Capsules 160mg, Metacavir Enteric-coated Capsules 320mg - Chronic Hepatitis B | Phase 2 | Unknown | Guangzhou Yipinhong Pharmaceutical CO.,LTD | 180 | 2012-12-01 | 2016-11-22 |
| TDF VS LAM + ADV in LAM + ADV Treated LAM-resistant CHB Patients With Undetectable Hepatitis B Virus DNA Lamivudine plus adefovir, Tenofovir - Chronic Hepatitis B | Phase 4 | Completed | Keimyung University Dongsan Medical Center | 171 | 2012-11-01 | 2016-10-28 |
| Switch to Tenofovir Versus Continue Lamivudine/Adefovir Treatment in Lamivudine-resistance Chronic Hepatitis B Patients Tenofovir disoproxil fumarate, Lamivudine plus adefovir - Chronic Hepatitis B | Phase 4 | Unknown | Taipei Veterans General Hospital, Taiwan | 160 | 2012-09-01 | 2016-04-01 |
| Antiviral Efficacy of Switching to ETV Plus TDF Group A (Zeffix, Sebivo, Hepsera), Group B (Baraclude, Viread) - Chronic Hepatitis B | Phase 4 | Unknown | Yonsei University | 104 | 2012-08-01 | 2014-01-31 |
| PEG-interferon Alfa-2a add-on Study in HBeAg Negative Chronic Hepatitis B Patients Peginterferon alfa-2a, Nucleos(t)ide analogue - Chronic Hepatitis B | Phase 4 | Completed | Foundation for Liver Research | 90 | 2012-05-25 | 2019-11-08 |
| A Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Clevudine and Adefovir Dipivoxil After Oral Administration in Healthy Male Subjects Clevudine, Adefovir dipivoxil , Clevudine+Adefovir dipivoxil, Clevudine; Adefovir dipivoxil ,Clevudine +Adefovir dipivoxil, Clevudine,Adefovir dipivoxil ,Clevudine +Adefovir dipivoxil - Healthy | Phase 1 | Completed | Bukwang Pharmaceutical | 42 | 2012-04-01 | 2012-09-18 |
| Clinical Effects and Cost-effectiveness Analysis of Early Anti-viral Therapy on HBV-related Compensated Liver Cirrhosis Entecavir, Lamivudine plus Adefovir Dipivoxil - Liver Cirrhosis, Hepatitis B | Unknown | Beijing Friendship Hospital | 621 | 2012-03-01 | 2015-07-28 | |
| Study of Effects and Safety Between Adefovir Dipivoxil Plus Polyene Phosphatidylcholine Versus Adefovir Dipivoxil Alone in Chronic Hepatitis B Patients Adefovir Dipivoxil and polyene phosphatidylcholine, Adefovir Dipivoxil - Chronic Hepatitis B | Phase 4 | Unknown | Jun Cheng | 300 | 2011-09-01 | 2011-09-19 |
| Comparison of Telbivudine Plus Adefovir With Lamivudine Plus Adefovir for the Treatment of Lamivudine-resistant Chronic Hepatitis B at 52 Weeks: A Pilot Study telbivudine plus adefovir, lamivudine plus adefovir - Chronic Hepatitis B | Phase 4 | Unknown | Korea University | 60 | 2011-05-01 | 2013-03-05 |
| Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) 300mg in Chinese Subjects With Chronic Hepatitis B (CHB) Tenofovir disoproxil fumarate (TDF) tablets, Adefovir dipivoxil (ADV) tablets - Hepatitis B | Phase 3 | Completed | GlaxoSmithKline | 512 | 2011-03-30 | 2018-07-13 |
| Lamivudine and Adefovir Dipivoxil Fixed Dose Combination Lamivudine, Adefovir dipivoxil, Fixed dose combination (Lamivudine and Adefovir dipivoxil) - Hepatitis B, Chronic | Phase 1 | Completed | GlaxoSmithKline | 40 | 2011-02-21 | 2017-08-04 |
| A Two-year Study of Telbivudine in HBeAg Negative Hepatitis Telbivudine, Adefovir dipivoxil - Hepatitis B, Chronic | Phase 4 | Completed | Third Affiliated Hospital, Sun Yat-Sen University | 360 | 2011-01-01 | 2017-10-24 |
| An Open Study to Evaluate the Efficacy, Safety of Clevudine Monotherapy or Adefovir and Clevudine Combination in Patients With Chronic Hepatitis B Clevudine 30mg, Clevudine 20mg+Adefovir dipivoxil 10mg, Clevudine 20mg - Chronic Hepatitis B | Phase 4 | Completed | Bukwang Pharmaceutical | 60 | 2010-03-01 | 2014-12-18 |
| Efficacy and Safety Study of Adefovir and Entecavir for Elderly With Chronic Hepatitis B Adefovir dipivoxil or Entecavir - Hepatitis B, Chronic | Completed | Ying-Jie Ji | 242 | 2010-01-01 | 2014-10-28 | |
| Entecavir Plus Adefovir in Lamivudine-Resistant Patients Lamivudine, Entecavir, Adefovir - Hepatitis B, Chronic | Phase 4 | Withdrawn | Bristol-Myers Squibb | 2009-12-01 | 2015-09-01 | |
| Entecavir Plus Adefovir in Lamivudine-Resistant Chronic Hepatitis B Patients Who Fail Lamivudine Plus Adefovir Adefovir, Entecavir, Lamivudine - Hepatitis B, Chronic | Phase 4 | Completed | Asan Medical Center | 90 | 2009-11-01 | 2014-02-10 |
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Hepatitis B, Chronic (41) · Hepatitis B (22) · HIV Infections (21) · Acquired Immunodeficiency Syndrome (6) · AIDS-Related Complex (3) · Fibrosis (3) · Carcinoma, Hepatocellular (2) · Bronchiolitis Obliterans Syndrome (1) · Cytomegalovirus Infections (1) · Disease Progression (1) · Hepatitis C (1) · Liver Cirrhosis (1) · Liver Failure, Acute (1) · Patient Compliance (1)
Gilead Sciences (20) · National Institute of Allergy and Infectious Diseases (NIAID) (9) · GlaxoSmithKline (8) · Bukwang Pharmaceutical (4) · Novartis (3) · Bristol-Myers Squibb (2) · Hoffmann-La Roche (2) · Korea University (2) · Merck Sharp & Dohme LLC (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Asan Medical Center (1) · Asian-Pacific Alliance of Liver Disease, Beijing (1) · Beijing Friendship Hospital (1) · Columbia University (1) · Foundation for Liver Research (1)
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PMID 19052126, PMID 20955704, PMID 23234725, PMID 23364953, PMID 23939953, PMID 25179493, PMID 25277773, PMID 25532501, PMID 25788199, PMID 25987775, PMID 27658343, PMID 28215615, PMID 30795958, PMID 31136052, PMID 11023461, PMID 12195349, PMID 15031785, PMID 15295692, PMID 15940636, PMID 15994231, PMID 16249704, PMID 16912304, PMID 17030856, PMID 17058225, PMID 17507321, PMID 17726714, PMID 17909201, PMID 20346062, PMID 2106474, PMID 21239359, PMID 21337357, PMID 23650172, PMID 2452123, PMID 25046847, PMID 25243325, PMID 27534671, PMID 29329305, PMID 30977033, PMID 31099252, PMID 31247117, PMID 3129521, PMID 32460460, PMID 32719417, PMID 33287722, PMID 33460002, PMID 35149125, PMID 40665748, PMID 41366186
2004 (2), U01DK057577 (1)