14 completed, 3 unknown, 2 withdrawn. 8 Phase 4, 3 Phase 3, 2 Not applicable, 2 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 8 | Completed 5, Unknown 2, Withdrawn 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective Study of HBV Immunity and HBV Vaccination in Patients With NAFLD in Canada Engerix-B - Non-Alcoholic Fatty Liver Disease, Hepatitis B | Completed | University of Calgary | 82 | 2016-08-01 | 2021-11-03 | |
| Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively Vaccination with vaccine against hepatitis A and B - Cystic Fibrosis, Hepatitis A | Not applicable | Withdrawn | Karolinska University Hospital | 2015-09-01 | 2024-03-18 | |
| Study of the Safety and Immunogenicity of Pfs230D1M-EPA/Alhydrogel and Pfs25M-EPA/Alhydrogel , a Transmission Blocking Vaccine Against Plasmodium Falciparum Malaria, in Adults in the U.S. and Mali Pfs230D1M-EPA/Alhydrogel, Pfs25M-EPA/Alhydrogel, TWINRIX - Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 538 | 2015-01-07 | 2019-04-11 |
| Cellular Immunity in Adult Hepatitis B-vaccinated Serologic Non-responders Twinrix - Hepatitis B | Phase 4 | Unknown | University of Aarhus | 400 | 2011-10-01 | 2012-10-26 |
| Indirect Effects of Pneumococcal Vaccine on Nasopharyngeal Carriage PCV GSK1024850A, hepatitis B vaccine or hepatitis A vaccine - Pneumococcal Infections | Completed | Arto Palmu | 2341 | 2011-04-01 | 2021-03-01 | |
| Combination Hepatitis A and B Vaccine to Induce Immunity in Non-responders Twinrix - Hepatitis B | Phase 4 | Withdrawn | Mount Sinai Hospital, Canada | 2010-04-01 | 2020-06-01 | |
| Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination Twinrix, Engerix-B, Havrix - Hepatitis A, Hepatitis B | Phase 4 | Completed | GlaxoSmithKline | 506 | 2008-05-26 | 2018-08-17 |
| Study to Show That the Combined Hepatitis A and B Vaccine is Non-inferior to Monovalent Vaccines in Adults Twinrix, Engerix-B, Havrix - Hepatitis B, Hepatitis A | Phase 4 | Completed | GlaxoSmithKline | 213 | 2008-01-01 | 2017-03-14 |
| Determining Responses to Two Different Vaccines in HIV and HCV Infected Individuals Twinrix, Decavac - HIV Infections, Hepatitis C | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 29 | 2007-08-01 | 2021-11-01 |
| Primary Study to Demonstrate Non-inferiority and Immunogenicity of GSK Biologicals' Meningococcal Vaccine 134612 Nimenrix (Meningococcal vaccine 134612), Twinrix - Infections, Meningococcal | Phase 3 | Completed | GlaxoSmithKline | 611 | 2007-04-11 | 2018-06-08 |
| Hepatitis Vaccination in HIV Infection: Role of Adjuvant Interleukin-2 Twinrix, interleukin-2 - HIV Infections, Hepatitis A | Phase 3 | Unknown | Aalborg University Hospital | 80 | 2007-03-01 | 2007-11-01 |
| Effectiveness of the Screen, Test, Immunize, Reduce Risk, and Refer (STIRR) Intervention for People With Both a Mental and Substance Abuse Disorder Twinrix, Enhanced treatment as usual - HIV Infections, Schizophrenia | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 236 | 2006-02-01 | 2013-05-22 |
| Immunologic Memory (Supp. of ATN 024) Engerix B, Twinrix for ATN 024, Recombivax - HIV Infections | Phase 4 | Completed | University of North Carolina, Chapel Hill | 95 | 2005-08-01 | 2017-02-28 |
| Efficacy Study of Combined Hepatitis A and Hepatitis B Vaccine to Protect Against Hepatitis B in Hemodialysis Patients Engerix-B and Twinrix - Hepatitis B | Phase 4 | Completed | St. Joseph's Health Care London | 200 | 2004-11-01 | 2007-04-20 |
| Long-term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Mth Schedule in Healthy Adults Twinrix™ - Hepatitis B, Hepatitis A | Phase 3 | Completed | GlaxoSmithKline | 50 | 2004-11-01 | 2018-08-17 |
| Twinrix Alternative Schedule Study Combined vaccine against hepatitis A and B (Twinrix) - Antibody Response After Vaccination | Phase 4 | Unknown | IDEWE Occupational Health Services | 400 | 2004-09-01 | 2005-12-14 |
| A Randomized Trial of Vaccine Adherence in Young Injection Drug Users Hepatitis A & B vaccine, Outreach, AIC - Medication Adherence, Substance Abuse, Intravenous | Not applicable | Completed | University of California, San Francisco | 546 | 2004-08-01 | 2013-09-30 |
| Effectiveness of Two Hepatitis B Vaccines in HIV-negative Youths Recombivax, Twinrix - Hepatitis B | Phase 2 | Completed | University of North Carolina, Chapel Hill | 123 | 2004-02-01 | 2017-03-29 |
| Effect of Risk Factors Likely to Influence Immuno of Combined Hepatitis A & B Vacc vs Monovalent Hepatitis A & B Vacc TWINRIX™, Engerix™-B, HAVRIX™ - Hepatitis B, Hepatitis A | Phase 4 | Completed | GlaxoSmithKline | 596 | 2003-11-24 | 2019-11-15 |
Hepatitis B (14) · Hepatitis A (8) · HIV Infections (4) · Hepatitis C (2) · Bipolar Disorder (1) · Cystic Fibrosis (1) · Depression (1) · Malaria (1) · Medication Adherence (1) · Meningococcal Infections (1) · Mental Disorders (1) · Non-alcoholic Fatty Liver Disease (1) · Pneumococcal Infections (1) · Psychotic Disorders (1) · Risk-Taking (1)
GlaxoSmithKline (5) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · University of North Carolina, Chapel Hill (2) · Aalborg University Hospital (1) · Arto Palmu (1) · Dartmouth-Hitchcock Medical Center (1) · IDEWE Occupational Health Services (1) · Karolinska University Hospital (1) · Mount Sinai Hospital, Canada (1) · St. Joseph's Health Care London (1) · University of Aarhus (1) · University of Calgary (1) · University of California, San Francisco (1)
United States (6) · Belgium (5) · Canada (3) · Denmark (3) · Czechia (2) · Germany (2) · Puerto Rico (2) · Sweden (2) · Finland (1) · Mali (1)
Allison J McGeer, MD MSc (1) · Antoon A De Schryver, M.D., PhD (1) · Arto A Palmu, M.D. (1) · Benigno Rodriguez, MD (1) · Carla Coffin (1) · Christine H Lee, MD (1) · Coleen K. Cunningham, MD (1) · Donald D. Anthony, MD, PhD (1) · Ferenc Karpati, MD, PhD (1) · Henrik Nielsen, MD, DMSci (1) · Lisa Dixon, MD (1) · Maria B Pedersen, Bach.Med (1) · Martin Tolstrup, MSc (1)
PMID 21366801, PMID 17980513, PMID 18233994, PMID 20173677, PMID 20630640, PMID 20810586, PMID 21241735, PMID 31307393, PMID 33561016, PMID 37027391, PMID 37499679, PMID 39787798
R01DA017476 (1), R01MH072556 (1), R21AI066957 (1)