91 completed, 17 unknown, 16 recruiting, 7 not yet recruiting. 145 Phase 1, 40 Phase 2.
Follow Hepatic Insufficiency: new trials by email Literature Review of Hepatic Insufficiency trials Research Report on Hepatic Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014) Ulonivirine - Hepatic Insufficiency | Phase 1 | Not yet recruiting | Merck Sharp & Dohme LLC | 22 | 2027-01-22 | 2026-07-16 |
| A Study to Evaluate the Pharmacokinetics and Safety of INCB161734 in Participants With Hepatic Impairment INCB161734 - Hepatic Insufficiency, Liver Diseases | Phase 1 | Not yet recruiting | Incyte Corporation | 24 | 2026-10-13 | 2026-10-01 |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation - Liver Failure | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-09-01 | 2026-10-07 |
| Umbilical Cord Mesenchymal Stem Cell Therapy for Biliary Atresia Umbilical Cord-Mesenchymal Stem Cells (UC-MSC), Kasai Portoenterostomy - Biliary Atresia, Kasai Operation | Phase 1 | Recruiting | Dr Cipto Mangunkusumo General Hospital | 40 | 2026-09-01 | 2026-09-09 |
| A Study to Learn How the Study Medicine Called Atirmociclib is Handled by the Body in People With Normal Liver Function and Different Levels of Liver Disease Atirmociclib - Hepatic Impairment, Healthy, Hepatic Insufficiency | Phase 1 | Recruiting | Pfizer | 28 | 2026-06-29 | 2026-08-21 |
| Pharmacokinetics and Safety of MDR-001 in Mild and Moderate Hepatic Impairment MDR-001 - Hepatic Impairment (Mild and Moderate, Child-Pugh Class A and B), Hepatic Insufficiency (MeSH ID: D048550) | Phase 1 | Not yet recruiting | MindRank AI Ltd | 32 | 2026-06-01 | 2026-04-24 |
| A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Moderate or Severe Hepatic Impairment INCB123667 - Hepatic Insufficiency, Liver Diseases | Phase 1 | Recruiting | Incyte Corporation | 16 | 2026-05-27 | 2026-06-16 |
| Evaluation of the Outcome of Fecal Microbiota Transplantation Fecal Microbiota Transplantation, FMT Matched Placebo, Rifaximin、Lactulose - Hepatic Encephalopathy, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Not yet recruiting | Air Force Military Medical University, China | 40 | 2026-03-07 | 2026-03-06 |
| Immune Tolerance Induction After Liver Transplantation Donor Hematopoietic Stem and Progenitor Cell Infusion - Liver Transplantation, Immune Tolerance | Phase 1 / Phase 2 | Recruiting | University of California, Los Angeles | 12 | 2026-02-20 | 2026-03-12 |
| A Study of Eloralintide (LY3841136) in Participants With Different Levels of Liver Damage and in Participants With Healthy Livers. LY3841136 - Hepatic Insufficiency | Phase 1 | Recruiting | Eli Lilly and Company | 36 | 2026-02-10 | 2026-06-04 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) umbilical cord Mesenchymal Stem Cell - Acute-On-Chronic Liver Failure | Phase 1 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 10 | 2026-01-01 | 2025-08-28 |
| Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome Chemically induced pluripotent stem cells biological Artificial Liver - Liver Failure, Small-for-Size Syndrome | Phase 1 / Phase 2 | Recruiting | Beijing Friendship Hospital | 12 | 2025-12-01 | 2026-04-20 |
| A Study of the Pharmacokinetics and Safety of LY3537031 in Participants With Normal Liver Function and With Mild, Moderate, or Severe Liver Impairment LY3537031 - Healthy, Hepatic Insufficiency | Phase 1 | Recruiting | Eli Lilly and Company | 32 | 2025-10-20 | 2026-09-30 |
| Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers Single Dose G1090N, Multiple dosing of G1090N - Acute-on-Chronic Liver Failure | Phase 1 | Completed | Genfit | 52 | 2025-08-26 | 2026-01-16 |
| A Study of Bomedemstat (MK-3543) in Participants With Mild or Moderate Hepatic Impairment (MK-3543-023) Bomedemstat - Hepatic Insufficiency | Phase 1 | Completed | Merck Sharp & Dohme LLC | 9 | 2025-08-20 | 2026-02-25 |
| A Study to Test How BI 1584862 is Taken up in the Blood of People With and Without Liver Problems BI 1584862 - Hepatic Insufficiency | Phase 1 | Completed | Boehringer Ingelheim | 43 | 2025-08-06 | 2026-07-07 |
| The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial Commensal Bacteria Strains - Liver Diseases, Liver Failure | Phase 1 | Recruiting | University of Chicago | 24 | 2025-08-04 | 2025-11-04 |
| A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose Sevabertinib - Hepatic Insufficiency, Liver Diseases | Phase 1 | Completed | Bayer | 18 | 2025-07-24 | 2026-02-10 |
| CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection Ex Vivo CRISPR-Cas9 Gene Editing of Donor Liver - Liver Diseases, Liver Cancer | Phase 1 / Phase 2 | Recruiting | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | 90 | 2025-06-01 | 2025-07-08 |
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Liver Failure (23) · Acute-On-Chronic Liver Failure (17) · End Stage Liver Disease (16) · Hepatic Encephalopathy (16) · Liver Diseases (16) · Liver Cirrhosis (11) · Fibrosis (10) · Liver Failure, Acute (7) · Renal Insufficiency (6) · Lymphoma, Follicular (4) · Neoplasm Metastasis (3) · Hepatitis B (2) · Hepatitis C (2) · Neoplasms (2)
Digestive System Diseases (145) · Liver Diseases (129) · Liver Failure (45) · Pathological Conditions, Signs and Symptoms (27) · Pathologic Processes (25) · Nutritional and Metabolic Diseases (20) · Metabolic Diseases (18) · Nervous System Diseases (18) · Central Nervous System Diseases (17) · Brain Diseases (16) · Brain Diseases, Metabolic (16) · Liver Failure, Acute (14) · Urogenital Diseases (10) · Female Urogenital Diseases (9)
Congresses as Topic (3) · Fecal Microbiota Transplantation (3) · Lactulose (2) · Ritonavir (2) · acalabrutinib (2) · cenicriviroc (2) · tipranavir (2) · Alitretinoin (1) · Amino Acids (1) · Amino Acids, Branched-Chain (1) · Antilymphocyte Serum (1) · Antiviral Agents (1) · Axitinib (1) · Azacitidine (1) · BI 1015550 (1)
Boehringer Ingelheim (12) · Eli Lilly and Company (12) · Merck Sharp & Dohme LLC (10) · Pfizer (6) · Third Affiliated Hospital, Sun Yat-Sen University (6) · Air Force Military Medical University, China (4) · Bristol-Myers Squibb (4) · University of Alberta (4) · Bayer (3) · Post Graduate Institute of Medical Education and Research, Chandigarh (3) · Virginia Commonwealth University (3) · Acerta Pharma BV (2) · Ahon Pharmaceutical Co., Ltd. (2) · Assistance Publique - Hôpitaux de Paris (2) · Beijing 302 Hospital (2)
United States (65) · China (24) · Germany (11) · Canada (6) · Hungary (6) · Spain (6) · France (5) · Belgium (4) · United Kingdom (4) · India (3) · Indonesia (2) · Italy (2) · Japan (2) · Romania (2) · Russia (2)
Daiming Fan (3) · Thomas Marbury, MD (2) · Yang Yang, PHD, MD (2) · Anil Dhawan, Professor (1) · Baburao Koneru, MD (1)
PMID 17903050, PMID 19221403, PMID 19455046, PMID 20512995, PMID 23453404, PMID 24704773, PMID 24782116, PMID 25659911, PMID 25715177, PMID 27129117, PMID 28284916, PMID 29177975, PMID 29197175, PMID 29247332, PMID 30568347, PMID 30863450, PMID 31038755, PMID 31751317, PMID 32031037, PMID 33011075, PMID 33123384, PMID 34866168, PMID 35313729, PMID 35674880, PMID 35728046, PMID 37975059, PMID 38109364, PMID 38153225, PMID 38869987, PMID 38925694, PMID 39442386, PMID 39934586, PMID 40233953, PMID 40663244, PMID 41503571, PMID 41903096, PMID 42597983, PMID 6749458, PMID 818729
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