12 completed, 5 unknown, 2 terminated. 9 Phase 3, 6 Phase 2, 2 Phase 1, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 6, Unknown 3 |
| Phase 2 | 6 | Completed 3, Unknown 2, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Alitretinoin: new trials by email Literature Review of Alitretinoin trials Research Report on Alitretinoin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema Delgocitinib, Toctino - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 513 | 2022-06-15 | 2025-05-09 |
| Utilizing the Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D as a Potent Quadrate Therapy for Treating Patients With Multidrug-resistant TB and Patient With Both Multidrug-resistant TB and COVID-19 13 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D for (MDR-TB), 9 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D for (MDR-TB), All trans retinoic acid , Minocycline,Chicroic Acid and Vitamin D for (MDR-TB) - Tuberculosis | Phase 2 | Unknown | Kafrelsheikh University | 250 | 2021-12-01 | 2021-10-14 |
| Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer. All trans-retinoic acid, 13-Cis Retinoic Acid plus Tocopherol, Mifepristone - Breast Cancer Female | Phase 3 | Unknown | Mahmoud Ramadan mohamed Elkazzaz | 160 | 2021-08-01 | 2021-08-23 |
| Alitretinoin vs Cyclosporine in Severe Recurrent Vesicular Hand Eczema Alitretinoin, cyclosporin A - Hand Eczema | Phase 3 | Unknown | University Medical Center Groningen | 76 | 2017-05-29 | 2019-02-26 |
| Alitretinoin vs Azathioprine in Severe Non-hyperkeratotic Hand Eczema Alitretinoin, Azathioprine - Hand Eczema | Phase 3 | Unknown | University Medical Center Groningen | 116 | 2016-05-01 | 2018-05-04 |
| Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin alitretinoin - Lichen Planus (LP) | Phase 2 | Unknown | University of Zurich | 20 | 2012-03-01 | 2012-03-20 |
| Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus Alitretinoin - Lupus Erythematosus, Cutaneous | Phase 2 | Terminated | University Hospital Muenster | 7 | 2011-08-01 | 2016-06-01 |
| Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis alitretinoin, Placebo - Psoriasis | Phase 2 | Completed | Stiefel, a GSK Company | 33 | 2011-04-26 | 2017-12-21 |
| Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease Alitretinoin - Hepatic Insufficiency | Phase 1 / Phase 2 | Completed | University Hospital, Gentofte, Copenhagen | 16 | 2010-12-01 | 2013-01-29 |
| Single Dose of 9-cis-retinoic Acid in Hepatic Patients 9-cis-retinoic acid - Hepatic Insufficiency | Completed | University Hospital, Gentofte, Copenhagen | 20 | 2010-12-01 | 2013-07-03 | |
| Ciclosporin Versus Alitretinoin for Severe Atopic Hand Dermatitis. Ciclosporin, Alitretinoin - Atopic Dermatitis | Phase 4 | Terminated | Technische Universität Dresden | 15 | 2010-11-01 | 2014-06-03 |
| Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema alitretinoin, Placebo - Eczema | Phase 3 | Completed | Stiefel, a GSK Company | 599 | 2009-01-08 | 2020-04-27 |
| Alitretinoin in the Treatment of Chronic Hand Eczema alitretinoin - Eczema | Phase 3 | Completed | Basilea Pharmaceutica | 150 | 2007-05-01 | 2023-05-10 |
| Safety and Efficacy of a Retinoid for the Treatment of Severe Chronic Hand Dermatitis alitretinoin - Hand Dermatoses | Phase 3 | Completed | Basilea Pharmaceutica | 250 | 2006-04-01 | 2023-05-10 |
| Follow-up Efficacy and Safety of Alitretinoin in Severe Chronic Hand Dermatitis alitretinoin - Hand Dermatoses | Phase 3 | Completed | Basilea Pharmaceutica | 300 | 2005-03-01 | 2023-05-10 |
| Efficacy and Safety of a Retinoid for the Treatment of Severe Chronic Hand Dermatitis alitretinoin - Hand Dermatoses | Phase 3 | Completed | Basilea Pharmaceutica | 1035 | 2004-12-01 | 2023-05-10 |
| A Phase I Trial of Tamoxifen and 9-Cis-Retinoic Acid in Breast Cancer Patients 9-cis-Retinoic Acid - Breast Cancer, Breast Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 18 | 1996-05-01 | 2008-03-04 |
| A Study of ALRT 1057 Topical Gel in Patients With AIDS-Related Kaposi's Sarcoma Alitretinoin - Sarcoma, Kaposi, HIV Infections | Not applicable | Completed | Anderson Clinical Research | 2005-06-24 | ||
| A Study of ALRT1057 in Patients With AIDS-Related Kaposi's Sarcoma Alitretinoin - Sarcoma, Kaposi, HIV Infections | Phase 2 | Completed | Anderson Clinical Research | 27 | 2005-06-24 |
Hand Dermatoses (3) · Eczema (2) · HIV Infections (2) · Hepatic Insufficiency (2) · Sarcoma, Kaposi (2) · AIDS-Related Opportunistic Infections (1) · Breast Neoplasms (1) · Dermatitis, Atopic (1) · Eczema, Dyshidrotic (1) · Lichen Planus (1) · Lupus Erythematosus, Cutaneous (1) · Lupus Erythematosus, Discoid (1) · Psoriasis (1) · Tuberculosis (1)
Basilea Pharmaceutica (4) · Anderson Clinical Research (2) · Stiefel, a GSK Company (2) · University Hospital, Gentofte, Copenhagen (2) · University Medical Center Groningen (2) · Kafrelsheikh University (1) · LEO Pharma (1) · Mahmoud Ramadan mohamed Elkazzaz (1) · National Cancer Institute (NCI) (1) · Technische Universität Dresden (1) · University Hospital Muenster (1) · University of Zurich (1)
Germany (8) · France (3) · Netherlands (3) · Canada (2) · Denmark (2) · Poland (2) · United Kingdom (2) · United States (2) · Austria (1) · Egypt (1) · Italy (1) · Norway (1) · Saudi Arabia (1) · Slovakia (1) · Spain (1)
Thomas Ruzicka, MD (2) · Amr Ahmed (1) · Amr K Ahmed (1) · Annegret Kuhn, Prof. Dr. (1) · Dr Mahmoud R Elkazzaz, M.Sc of Biochemistry (1) · Mahmoud Elkazzaz (1) · Reinhard Dummer, Prof. MD (1) · Thomas Diepgen, MD (1)
PMID 19659963, PMID 25607554, PMID 26507685, PMID 29997136, PMID 40252681
2009 (1)