12 completed. 12 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 12 |
Follow Heartburn: new trials by email Literature Review of Heartburn trials Research Report on Heartburn
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily Vonoprazan - Erosive Esophagitis, Heartburn | Phase 1 | Completed | Phathom Pharmaceuticals, Inc. | 15 | 2024-05-07 | 2025-03-25 |
| A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants bi-layer calcium carbonate tablet (BAY1180654), Immediate release calcium carbonate tablet (BAY1180654) - Heartburn, Indigestion | Phase 1 | Completed | Bayer | 21 | 2024-03-06 | 2024-07-03 |
| Ethacrynic Acid Elimination in Non-Muscle Invasive Bladder Cancer Patients Undergoing Transurethral Resection Ethacrynic Acid - Bladder Cancer | Phase 1 | Completed | Eugene Lee, MD | 12 | 2016-08-01 | 2017-08-22 |
| Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets Dexlansoprazole - Gastroesophageal Reflux Disease, Erosive Esophagitis | Phase 1 | Completed | Takeda | 8 | 2014-02-01 | 2015-03-06 |
| A Study to Compare Omeprazole Administered as Zegerid® Powder and as Prilosec® Capsule in Healthy Participants (P08050)(CL2010-12) omeprazole/sodium bicarbonate, omeprazole magnesium - Heartburn | Phase 1 | Completed | Bayer | 50 | 2011-01-01 | 2015-02-23 |
| Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn Dexlansoprazole - Heartburn, Gastroesophageal Reflux Disease | Phase 1 | Completed | University of North Carolina, Chapel Hill | 40 | 2010-06-01 | 2016-12-19 |
| Do Acid Sensing Ion Channels Contribute to Heartburn? Amiloride, Placebo - Gastroesophageal Reflux Disease, Heartburn | Phase 1 | Completed | University of North Carolina, Chapel Hill | 24 | 2010-03-01 | 2012-09-20 |
| Pharmacokinetic and Safety of Dexlansoprazole in Adolescents With Gastroesophageal Reflux Disease Dexlansoprazole MR - Gastroesophageal Reflux | Phase 1 | Completed | Takeda | 36 | 2009-05-01 | 2012-02-02 |
| Effect of Vecam 40/300 and Vecam 20/300 Compared to Omeprazole 20 mg on Gastric pH Omeprazole, Vecam - Gastroesophageal Reflux | Phase 1 | Completed | Vecta Ltd. | 60 | 2008-12-01 | 2010-01-27 |
| Uric Acid Study in Healthy Male Volunteers AZD6140, Placebo to match AZD6140 - Gout, Coronary Artery Disease | Phase 1 | Completed | AstraZeneca | 24 | 2008-05-01 | 2010-12-03 |
| A Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets Compared to Famotidine/Antacid EZ Chew Tablets (0208C-145)(COMPLETED) famotidine (+) calcium carbonate (+) magnesium hydroxide tablet, Comparator: famotidine (+) calcium carbonate (+) magnesium hydroxide EZ Chew tablet without water, Comparator: famotidine (+) calcium carbonate (+) magnesium hydroxide EZ Chew tablet with water - Heartburn | Phase 1 | Completed | Johnson & Johnson Consumer and Personal Products Worldwide | 24 | 2008-02-01 | 2015-06-24 |
| A Study to Assess the Bioequivalence of Famotidine Chewable Tablets and Film-Coated Tablets (0208-144) Famotidine FCT, Famotidine CT - Heartburn | Phase 1 | Completed | Merck Sharp & Dohme LLC | 30 | 2006-08-01 | 2017-03-10 |
Gastroesophageal Reflux (5) · Coronary Artery Disease (1) · Dyspepsia (1) · Gout (1) · Laryngopharyngeal Reflux (1) · Neoplasms (1) · Non-Muscle Invasive Bladder Neoplasms (1) · Urinary Bladder Neoplasms (1)
Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (12) · Signs and Symptoms, Digestive (12) · Deglutition Disorders (5) · Digestive System Diseases (5) · Esophageal Diseases (5) · Esophageal Motility Disorders (5) · Gastrointestinal Diseases (5) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Arthritis (1) · Carcinoma (1) · Cardiovascular Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Coronary Disease (1)
Dexlansoprazole (3) · Famotidine (2) · Lansoprazole (2) · Omeprazole (2) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (1) · Amiloride (1) · Calcium Carbonate (1) · Ethacrynic Acid (1) · Magnesium Hydroxide (1) · Suspensions (1) · Ticagrelor (1) · Water (1) · omeprazole, sodium bicarbonate drug combination (1)
Bayer (2) · Takeda (2) · University of North Carolina, Chapel Hill (2) · AstraZeneca (1) · Eugene Lee, MD (1) · Johnson & Johnson Consumer and Personal Products Worldwide (1) · Merck Sharp & Dohme LLC (1) · Phathom Pharmaceuticals, Inc. (1) · Vecta Ltd. (1)
United States (7) · United Kingdom (1)
Eugene K Lee, MD (1) · Kathleen Butler, MD (1) · Roy C Orlando, MD (1) · Roy Orlando, MD (1) · Stuart Harris, MD (1) · Vijayalakshmi S Pratha, MD (1)