85 completed, 54 unknown, 52 recruiting, 19 terminated. 74 Not applicable, 38 Phase 2, 27 Phase 4, 16 Phase 3, 9 Phase 1.
Follow Heart Failure With Preserved Ejection Fraction: new trials by email Literature Review of Heart Failure With Preserved Ejection Fraction trials Research Report on Heart Failure With Preserved Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry GLP-1 / GIP receptor agonist - Heart Failure With Preserved Ejection Fraction, Obesity | Not yet recruiting | Miedziowe Centrum Zdrowia SA | 150 | 2027-01-01 | 2026-08-26 | |
| Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction PADN, Sham procedure, GDMT - Heart Failure With Preserved Ejection Fraction | Not applicable | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 310 | 2026-12-30 | 2026-05-27 |
| Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction Colchicine, Placebo - Heart Failure With Preserved Ejection Fraction, Microvascular Coronary Artery Disease | Phase 2 | Recruiting | Montreal Heart Institute | 64 | 2026-11-06 | 2026-11-10 |
| Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction Exercise Cardiovascular Magnetic Resonance - Heart Failure With Preserved Ejection Fraction | Recruiting | Mayo Clinic | 400 | 2026-11-01 | 2026-08-20 | |
| IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency Ferric derisomaltose, Placebo (normal saline) - Heart Failure With Preserved Ejection Fraction, Iron Deficiency | Phase 4 | Not yet recruiting | Duke University | 300 | 2026-11-01 | 2026-10-15 |
| HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction HS235, Placebo - Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction | Phase 1 / Phase 2 | Recruiting | 35Pharma Inc., a GSK company | 126 | 2026-10-21 | 2026-10-30 |
| CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction) Catheter ablation - Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction | Not applicable | Not yet recruiting | Tulane University | 900 | 2026-10-01 | 2026-10-01 |
| Finerenone and Cardiac Remodeling in HFpEF Finerenone, Standard of care for HFpEF Description: - Heart Failure With Preserved Ejection Fraction | Phase 4 | Not yet recruiting | Assiut University | 194 | 2026-09-20 | 2026-09-22 |
| Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction Sacubitril-valsartan, Valsartan - Heart Failure With Preserved Ejection Fraction, Myocardial Fibrosis | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2026-08-27 | 2026-08-31 | |
| A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF) EDG-15400 25 mg, Placebo to match EDG-15400 25 mg or 50 mg, EDG-15400 50 mg - Heart Failure With Preserved Ejection Fraction | Phase 2 | Recruiting | Edgewise Therapeutics, Inc. | 90 | 2026-08-25 | 2026-10-13 |
| A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease Pulmonary Artery Denervation (PADN), Sham procedure control - Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction | Not applicable | Recruiting | Pulnovo Medical, Inc. | 750 | 2026-08-21 | 2026-11-10 |
| Incretin Therapies in Obesity-related HFpEF Tirzepatide - Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction | Phase 4 | Recruiting | Columbia University | 50 | 2026-08-07 | 2026-08-24 |
| EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC) Activin ligand-trap biological therapy, Placebo, Normal Saline - Heart Failure With Preserved Ejection Fraction | Phase 2 | Recruiting | Massachusetts General Hospital | 48 | 2026-06-03 | 2026-07-09 |
| BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching multi-domain behavioral, coaching, and exercise protocol - Heart Failure With Preserved Ejection Fraction | Not applicable | Recruiting | Wake Forest University Health Sciences | 14 | 2026-05-05 | 2026-05-26 |
| A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction HRS-1893 Tablet, HRS-1893 Tablet Placebo - Heart Failure With Preserved Ejection Fraction | Phase 2 | Recruiting | Shandong Suncadia Medicine Co., Ltd. | 48 | 2026-03-30 | 2026-05-11 |
| A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure 68Ga-FAPI (gallium-68-labeled fibroblast activation protein inhibitor) - Heart Failure With Preserved Ejection Fraction | Phase 2 | Recruiting | Mayo Clinic | 35 | 2025-11-01 | 2026-07-08 |
| A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD Cardiovascular Magnetic Resonance (CMR) - Heart Failure With Preserved Ejection Fraction, Coronary Microvascular Dysfunction | Recruiting | Mayo Clinic | 25 | 2025-10-16 | 2026-02-27 | |
| Remote Rehabilitation in Patients With HFpEF (PATRON-HF) Telerehabilitation - Heart Failure With Preserved Ejection Fraction | Not applicable | Recruiting | American Heart of Poland | 110 | 2025-09-30 | 2026-11-05 |
| Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Versus Medical Rate Control pacemaker implantation, atrioventricular node ablation, Pacemaker programming - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation, Persistent | Not applicable | Recruiting | French Cardiology Society | 266 | 2025-09-10 | 2026-09-11 |
| AI-based Echocardiographic Quantification in Heart Failure AI-based image analysis, AI-based imaging analysis - Heart Failure With Preserved Ejection Fraction | Not yet recruiting | Mackay Memorial Hospital | 3000 | 2025-07-01 | 2025-06-15 |
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Heart Failure (79) · Heart Failure, Diastolic (24) · Obesity (14) · Diabetes Mellitus, Type 2 (13) · Hypertension (12) · Hypertension, Pulmonary (12) · Cardiovascular Diseases (9) · Heart Diseases (7) · Inflammation (7) · Atrial Fibrillation (6) · Amyloid Neuropathies, Familial (4) · Heart Failure, Systolic (4) · Iron Deficiencies (4) · Cardiomyopathy, Hypertrophic (3) · Dyspnea (3)
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empagliflozin (10) · sacubitril and valsartan sodium hydrate drug combination (9) · Echocardiography (8) · dapagliflozin (8) · Saline Solution (5) · Standard of Care (4) · Valsartan (4) · Adrenergic beta-Antagonists (3) · Carvedilol (3) · Exercise (3) · Hematologic Tests (3) · Metoprolol (3) · Nebivolol (3) · ferric derisomaltose (3) · formic acid 4-(3-oxobutyl)phenyl ester (3)
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PMID 35241246, PMID 42669134, PMID 15860469, PMID 15963399, PMID 19168519, PMID 20607462, PMID 20800804, PMID 21329845, PMID 21440872, PMID 21885793, PMID 22291430, PMID 22980301, PMID 22983988, PMID 23463155, PMID 23743396, PMID 24388161, PMID 24658015, PMID 25046483, PMID 25282032, PMID 25344549, PMID 25354950, PMID 25398313, PMID 25399909, PMID 25415957, PMID 26033771, PMID 26082167, PMID 26240596, PMID 26378978, PMID 26449137, PMID 26568833, PMID 26635076, PMID 26746456, PMID 26941415, PMID 27179829, PMID 27788392, PMID 27940967, PMID 28028584, PMID 28100627, PMID 28329385, PMID 28402411, PMID 28408024, PMID 28444160, PMID 28662936, PMID 28705910, PMID 28785469, PMID 28993402, PMID 29430747, PMID 29449367, PMID 29523517, PMID 29602583
2016 (2), 2019 (2), K76AG064428 (2), 2018 (1), 2023 (1), I01RX003343 (1), K23GM112014 (1), K23HL150236 (1), K23HL168163 (1), P30AG021332 (1), R01AG078153 (1), R01AG097715 (1), R01HL131823 (1), R01HL151841 (1), R03AG064371 (1)