16 recruiting, 11 completed, 6 unknown, 4 not yet recruiting. 16 Phase 3, 14 Phase 4, 3 Phase 2, 1 Early Phase 1, 1 Not applicable.
Follow ferric derisomaltose: new trials by email Literature Review of ferric derisomaltose trials Research Report on ferric derisomaltose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency Ferric derisomaltose, Placebo (normal saline) - Heart Failure With Preserved Ejection Fraction, Iron Deficiency | Phase 4 | Not yet recruiting | Duke University | 300 | 2026-11-01 | 2026-10-15 |
| IRONCARE: Iron Treatment in Older Patients With Hip Fractures Ferric Derisomaltose, Oral Iron (Ferrous sulphate), Placebo IV - Hip Fracture, Anemia | Phase 4 | Not yet recruiting | University of Aarhus | 528 | 2026-10-01 | 2026-06-24 |
| A Study of Ferric Derisomaltose Injection in Chinese Participants With Iron Deficiency Anemia Under Fasting Conditions Ferric Derisomaltose Injection, Ferric Derisomaltose Injection [MonoFer®] - Iron Deficiency Anemia | Phase 1 | Recruiting | Sichuan Huiyu Pharmaceutical Co., Ltd | 88 | 2026-07-23 | 2026-10-13 |
| Intravenous Iron to Improve Symptoms, Quality of Life and Exercise Capacity in HFpEF With Iron Deficiency Ferric Derisomaltose, Placebo - Heart Failure With Preserved Ejection Fraction (HFpEF | Phase 2 | Enrolling by invitation | Government of Jersey | 150 | 2026-06-19 | 2026-08-24 |
| Postoperative Intravenous Ferric Derisomaltose for Prevention of Long-term Anemia After Cardiac Surgery Ferric derisomaltose, Placebo (0.9% saline) - Anemia, Iron Deficiencies | Phase 4 | Not yet recruiting | Yonsei University | 180 | 2025-12-01 | 2025-11-20 |
| Comparing High and Low Dose Iron Treatments for People on Peritoneal Dialysis: The PALaDIN Study Monofer (iron isomaltoside 1000), Ferrous Sulfate - Peritoneal Dialysis, Anaemia | Phase 3 | Recruiting | Hull University Teaching Hospitals NHS Trust | 30 | 2025-11-13 | 2026-05-06 |
| The Effects of Intravenous Iron on Mobility in Elderly Patients Following Hip Fracture Surgery Ferric Derisomaltose, Saline (NaCl 0,9 %) (placebo) - Hip Fracture, Anemia | Phase 4 | Recruiting | Soren Overgaard | 210 | 2025-06-09 | 2026-06-01 |
| Multi-center Trial of Ferric Derisomaltose Versus no Intravenous Iron in Iron-deficient Subjects With Symptomatic Chronic Heart Failure Ferric Derisomaltose - Chronic Heart Failure, Iron Deficiencies | Phase 3 | Recruiting | Pharmacosmos A/S | 1900 | 2025-05-01 | 2026-10-05 |
| Ferric Derisomaltose and Outcomes in the Recovery of Gynecologic Oncology: ERAS (Enhanced Recovery After Surgery) Ferric derisomaltose, Placebo - Gynecologic Cancer, Anemia | Phase 3 | Recruiting | AHS Cancer Control Alberta | 82 | 2025-04-08 | 2026-10-28 |
| Post-operative Intravenous Iron to Treat Iron-deficiency Anemia in Patients Undergoing Cardiac Surgery Monoferric Injectable Product, 0.9% sodium chloride solution - Chronic Iron Deficiency Anaemia, Cardiac Surgery | Phase 2 | Recruiting | University Health Network, Toronto | 60 | 2025-04-03 | 2026-02-10 |
| IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure Ferric derisomaltose - Heart Failure, Iron Deficiencies | Recruiting | University Hospital Southampton NHS Foundation Trust | 16 | 2024-04-15 | 2024-08-07 | |
| Effect of Intravenously Iron Infusion on the Prevention and Treatment of Anemia in Ovarian Cancer IV iron - Anaemia in Ovarian Carcinoma | Phase 3 | Not yet recruiting | University of Saskatchewan | 200 | 2024-02-29 | 2024-02-08 |
| Monoferric for Prenatal Iron Deficiency Ferric derisomaltose - Obstetric Labor Complications | Early Phase 1 | Recruiting | Oregon Health and Science University | 80 | 2024-01-18 | 2024-09-19 |
| Iron Deficiency Anemia (IDA) and the Brain Ferric derisomaltose, NovaFerrum - IDA - Iron Deficiency Anemia, Anemia | Phase 4 | Recruiting | Children's Hospital Los Angeles | 120 | 2023-12-07 | 2024-10-30 |
| The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency High-dose ferric derisomaltose, Low-dose ferric derisomaltose - Heart Failure, Iron Deficiency | Phase 4 | Recruiting | China-Japan Friendship Hospital | 114 | 2023-10-01 | 2025-02-19 |
| The Effects of Ferric Derisomaltose on Postoperative Anemia in Spinal Deformity Surgery Ferric derisomaltose, Ferrous succinate - Perioperative Anemia, Surgery | Phase 4 | Recruiting | Peking Union Medical College Hospital | 120 | 2023-08-31 | 2025-06-13 |
| The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life Ferric derisomaltose, Placebo - Heart Failure With Preserved Ejection Fraction, Iron Deficiencies | Phase 4 | Unknown | China-Japan Friendship Hospital | 170 | 2023-08-01 | 2023-09-26 |
| The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life(COREVIVE-HFrEF) Ferric derisomaltose, Placebo - Heart Failure With Reduced Ejection Fraction, Iron Deficiency | Phase 4 | Unknown | China-Japan Friendship Hospital | 146 | 2023-08-01 | 2023-08-15 |
| Accelerated Recovery for Total Knee Replacement Surgery With Preoperative Intravenous Iron Combined With Human Erythropoietin for Rapid Hematopoietic Mobilization to Prevent Postoperative Anemia Ferric Derisomaltose Injection (Monoferric) and Human Erythropoietin Injection (EPIAO), Basic Treatment - Total Knee Arthroplasty | Not applicable | Unknown | West China Hospital | 419 | 2023-07-01 | 2023-06-22 |
| Preoperative Monoferric for Abdominal Surgery Monoferric - Anemia, Surgery | Phase 4 | Completed | Brigham and Women's Hospital | 37 | 2023-04-18 | 2026-08-26 |
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Anemia, Iron-Deficiency (18) · Iron Deficiencies (13) · Anemia (12) · Heart Failure (3) · Hip Fractures (2) · Hypophosphatemia (2) · Renal Insufficiency, Chronic (2) · Autism Spectrum Disorder (1) · Emergencies (1) · Fatigue (1) · Heart Valve Diseases (1) · Obstetric Labor Complications (1) · Uterine Hemorrhage (1) · Ventricular Dysfunction, Left (1)
Pharmacosmos A/S (7) · China-Japan Friendship Hospital (3) · Thomas Jefferson University (3) · AHS Cancer Control Alberta (1) · Alberta Health Services, Calgary (1) · Baylor College of Medicine (1) · Brigham and Women's Hospital (1) · Children's Hospital Los Angeles (1) · Duke University (1) · Government of Jersey (1) · Hallym University Medical Center (1) · Hull University Teaching Hospitals NHS Trust (1) · Massachusetts General Hospital (1) · Michael Kremke (1) · Oregon Health and Science University (1)
United States (14) · China (6) · Canada (4) · Denmark (3) · India (3) · United Kingdom (3) · South Korea (2) · Jersey (1) · Netherlands (1)
Richard Derman, MD, MPH (3) · Andrew Mitchell (1) · Andrew S Flett, MBBS BSc MD (1) · David L. Hepner, MD (1) · Greg Lewis, MD (1) · Jeannie Callum, MD (1) · Jianxiong Shen, MD (1) · John Aaron Henry (1) · John Wood, MD, PhD (1) · Justyna Bartoszko, MD (1) · Marat Fudim (1) · Maryam Al-Hayki (1) · Methodius Tuuli, MD, MPH, MBA (1) · Michael Kremke, MD (1)
PMID 31243803, PMID 32016310, PMID 21240875, PMID 21439379, PMID 32049331, PMID 35781129, PMID 35948408, PMID 36347265, PMID 37885026, PMID 37945297, PMID 38124098, PMID 39161801, PMID 39443013, PMID 39453738, PMID 39938943, PMID 42442814
R01AG097715 (1), R01HL151841 (1), R01NS117430 (1)