155 completed, 23 recruiting, 19 terminated, 18 unknown. 89 Not applicable, 27 Phase 3, 21 Phase 4, 20 Phase 2, 9 Phase 1.
Follow Heart Disease: new trials by email Literature Review of Heart Disease trials Research Report on Heart Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE) Acoramidis (AG10) - Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial | Phase 3 | Not yet recruiting | Eidos Therapeutics, a BridgeBio company | 250 | 2026-11-01 | 2026-08-11 |
| PULSTA TPV Observational Study Heart Disease | Not yet recruiting | Taewoong Medical Co., Ltd. | 200 | 2026-10-01 | 2026-08-10 | |
| Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) Mitral Valve Replacement - Mitral Regurgitation, Heart Disease | Not applicable | Recruiting | InnovHeart | 15 | 2026-08-05 | 2026-08-10 |
| Outpatient Rehabilitation Programmes for Myocardial Ischemia, Heart Failure, and COPD: Satisfaction, Participation, Test Outcomes, and Factors Associated With Positive Changes in Test Results as Well as Level of Participation Heart Disease, COPD | Not yet recruiting | Nordsjaellands Hospital | 840 | 2026-08-01 | 2026-05-19 | |
| A Usability Study of a Multi-channel ECG Monitoring Device eWave Patch - Healthy Adult Participants, Heart Disease | Not applicable | Recruiting | Wearlinq | 500 | 2026-07-06 | 2026-07-21 |
| Moxie Self-Management and Education Support Program Moxie SMES Letters, Facilitated Relay Letter - Chronic Kidney Disease, Diabetes (DM) | Not applicable | Not yet recruiting | University of Calgary | 9000 | 2026-06-01 | 2026-05-11 |
| Validation of Remote Photoplethysmography (rPPG)-Derived Cardiovascular Parameters Against Standard Clinical Measurements and Risk Scores in a Community Dyslipidemia, Angina (Stable) | Not yet recruiting | Tarumanagara University | 300 | 2026-04-23 | 2026-04-20 | |
| Cobas® Lumira Collection of Venous and Capillary Blood Samples for the Research, Optimization and Calibration of New Diagnostic Devices Blood samples are obtained and pseudonymized, prior to use for the development, optimization and calibration of diagnostic tests - Blood Clots, Infection and Inflammatory Reaction | Not yet recruiting | LumiraDx UK Limited | 30000 | 2026-04-01 | 2026-01-30 | |
| The Relationship Between Blood Flow Readings During Surgery and How Well the Graft Stays Open and How Patients Recover Afterward in Coronary Artery Bypass Graft Surgery Transit-Time Flow Measurement (TTFM) - CABG Graft Integrity, CABG | Not applicable | Recruiting | Weill Medical College of Cornell University | 1242 | 2026-03-30 | 2026-04-22 |
| A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound Focused Cardiac Ultrasound, 6-Lead AI-ECG, 12-Lead AI-ECG - Heart Disease | Not applicable | Recruiting | Mayo Clinic | 19300 | 2026-03-09 | 2026-08-20 |
| Pathways to Prevention Food-is-Medicine Trial Nutrition Education, PRO-CVH, Healthy Conversation Skills - Heart Disease, Cardiovascular Health Status | Not applicable | Recruiting | Amrik Singh Khalsa | 120 | 2026-02-26 | 2026-05-15 |
| Can Tiny Bubbles Offer an Alternative to Catheters for Assessing Pressures Inside the Heart? Investigating Ultrasound Contrast Agents as Pressure Sensors Against Gold Standard Catheter Pressures in Cardiac Catheterisation Patients. Contrast Echocardiography - HFpEF - Heart Failure With Preserved Ejection Fraction, Cardiac Catheterisation | Not applicable | Recruiting | King's College London | 10 | 2026-02-01 | 2026-02-18 |
| Optimal Settings for Anti Tachycardia Pacing (ATP) on ICD Burst, Ramp - Heart Disease, Implantable Cardioverter Defibrillator (ICD) | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 3980 | 2026-02-01 | 2026-09-04 |
| Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35 - Heart Disease | Not applicable | Recruiting | AHEPA University Hospital | 70 | 2026-01-19 | 2026-08-19 |
| Accuracy of a Cuffless Photoplethysmography (PPG) Chest-Patch Monitor for 24-hour Ambulatory Blood Pressure Monitoring (ABPM) Model BB-613WP - Blood Pressure, Heart Disease | Not applicable | Completed | Biobeat Technologies Ltd. | 612 | 2025-12-15 | 2026-09-16 |
| Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation Cardiac Rehabilitation, Heart Disease | Recruiting | Duke University | 150 | 2025-12-02 | 2025-12-03 | |
| The Feasibility of an Intervention Targeting Sources of Meaning in Cardiac Rehabilitation Conversation on Sources of Meaning in life with heart disease, Group based session on Sources of Meaning in life with heart disease, Dyadic Conversation on Sources of Meaning in Life with heart disease - Heart Disease, Mental Health Outcomes | Not applicable | Enrolling by invitation | University of Southern Denmark | 80 | 2025-11-20 | 2026-01-13 |
| Interprofessional Pharmacogenomics (IPGx) Registry and Repository Diabetes, Cholesterol | Recruiting | Texas A&M University | 3000 | 2025-11-01 | 2025-09-12 | |
| Feasibility Study of the Supira System in Patients Undergoing HRPCI With Support Beyond the PCI Procedure Supira System - Heart Disease, Coronary Arterial Disease (CAD) | Not applicable | Recruiting | Supira Medical | 45 | 2025-10-12 | 2026-02-17 |
| Healthy Living Anson Study Nutrition Education and Food Delivery, Physical Activity Comparator - Obesity (Disorder), Diabetes Type 2 | Not applicable | Completed | University of North Carolina, Chapel Hill | 44 | 2025-09-24 | 2026-09-28 |
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Heart Diseases (238) · Cardiovascular Diseases (34) · Diabetes Mellitus (31) · Heart Failure (25) · Hypertension (20) · Coronary Artery Disease (17) · Stroke (15) · Neoplasms (11) · Depression (10) · Obesity (10) · Vascular Diseases (10) · Myocardial Infarction (9) · Myocardial Ischemia (9) · Arrhythmias, Cardiac (8) · Diabetes Mellitus, Type 2 (8)
Cardiovascular Diseases (204) · Pathological Conditions, Signs and Symptoms (76) · Vascular Diseases (68) · Nutritional and Metabolic Diseases (56) · Pathologic Processes (49) · Metabolic Diseases (48) · Glucose Metabolism Disorders (40) · Endocrine System Diseases (38) · Signs and Symptoms (27) · Myocardial Ischemia (25) · Behavior (22) · Respiratory Tract Diseases (21) · Arterial Occlusive Diseases (19) · Nervous System Diseases (19) · Arteriosclerosis (17)
Sodium Chloride (5) · Dexmedetomidine (4) · Therapeutics (4) · Adrenergic beta-Antagonists (3) · Aspirin (3) · Cardiac Rehabilitation (3) · Coronary Artery Bypass (3) · Defibrillators, Implantable (3) · Ezetimibe (3) · Metoprolol (3) · Acebutolol (2) · Atenolol (2) · Atorvastatin (2) · Betaxolol (2) · Bisoprolol (2)
University Health Network, Toronto (8) · University of Edinburgh (8) · National Heart, Lung, and Blood Institute (NHLBI) (6) · Emory University (4) · National Institute of Environmental Health Sciences (NIEHS) (4) · Weill Medical College of Cornell University (4) · Abbott Medical Devices (3) · Cedars-Sinai Medical Center (3) · Children's Hospital Medical Center, Cincinnati (3) · Copenhagen University Hospital, Rigshospitalet (3) · Duke University (3) · Helse Nord-Trøndelag HF (3) · National Human Genome Research Institute (NHGRI) (3) · Organon and Co (3) · Ottawa Heart Institute Research Corporation (3)
United States (123) · Canada (23) · United Kingdom (15) · Denmark (13) · Italy (12) · France (11) · Germany (10) · Norway (8) · Poland (8) · Spain (8) · Australia (6) · Belgium (5) · Sweden (5) · Austria (4) · Israel (4)
David E Newby, PhD FRCP (3) · Anne Murray, MD, MSc (2) · Bronwyn A Kingwell, PhD (2) · Frank E Speizer, MD (2) · Gareth D Barnes, MBChB (2) · Gary V. Heller, M.D., Ph.D. (2) · George N Djaiani, MD (2) · Grace McComsey, MD (2) · Jean-Bernard Durand, MD (2) · Jeff Miller, MD (2) · John McNeil, MBBS, PHD (2) · Laura M Koehly, Ph.D. (2) · Parag Goyal, MD (2) · Rebecca Seguin, PhD (2)
PMID 23519586, PMID 10564301, PMID 10954759, PMID 11581152, PMID 12680494, PMID 15507261, PMID 16339220, PMID 16732033, PMID 17382119, PMID 17543250, PMID 17562958, PMID 17994292, PMID 18221434, PMID 18310163, PMID 18778948, PMID 18824748, PMID 19019244, PMID 19049753, PMID 19175450, PMID 19281927, PMID 19288584, PMID 19329766, PMID 19349317, PMID 19359142, PMID 19384218, PMID 19422296, PMID 19477891, PMID 19717473, PMID 19753491, PMID 19767408, PMID 19901191, PMID 19920766, PMID 19962772, PMID 20074751, PMID 20083683, PMID 20187985, PMID 20565161, PMID 20598972, PMID 20685401, PMID 21108561, PMID 21224289, PMID 21242192, PMID 21293878, PMID 21296957, PMID 21386974, PMID 21397284, PMID 21412912, PMID 21415073, PMID 21429209, PMID 21447948
2008 (2), 2016 (1), K01HL177266 (1), K23HL159312 (1), K76AG064428 (1), OT2HL158287 (1), P50HL105188 (1), P50MD017356 (1), R01HG007746 (1), R01HL062705 (1), R01HL083857 (1), R01HL117939 (1), R01HL125442 (1), R01HL133667 (1), R01HL168854 (1)