30 completed, 8 recruiting, 8 unknown, 6 terminated. 24 Phase 3, 19 Phase 2, 14 Phase 1, 6 Phase 4, 5 Not applicable.
Follow rifapentine: new trials by email Literature Review of rifapentine trials Research Report on rifapentine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB) Isoniazid, Rifampin, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 900 | 2026-10-30 | 2026-08-19 |
| A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV Rifapentine, Isoniazid, Dolutegravir - Tuberculosis | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 144 | 2026-09-28 | 2026-10-19 |
| Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB Bedaquiline, Isoniazid, rifapentine, Levofloxacin - Tuberculosis, Latent | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 2530 | 2026-05-08 | 2026-10-20 |
| Pharmacokinetics of Antituberculosis Drugs in Breastfeeding Women Standard dose rifampicin, High dose rifampicin, Standard dose isoniazid - Tuberculosis Infection, Healthy Volunteer | Phase 1 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 60 | 2026-04-01 | 2026-02-10 |
| Shorter and Safer Treatment Regimens for Latent TB rifampin standard arm, rifampin double dose, levofloxacin and rifapentine - Tuberculosis Infection, Latent | Phase 2 / Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 1800 | 2025-06-10 | 2026-05-11 |
| Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis Rifampin, Isoniazid, Rifapentine (RPT) - Mild Spinal Tuberculosis | Phase 2 | Not yet recruiting | Shandong University | 300 | 2025-04-05 | 2025-04-08 |
| Shortened Regimen for Drug-susceptible TB in Children Isoniazid, Rifampin, Pyrazinamide - Tuberculosis, Tuberculosis, Pulmonary | Phase 3 | Recruiting | Johns Hopkins University | 860 | 2025-01-15 | 2026-07-24 |
| Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention Rifapentine, Dolutegravir - Pediatric HIV Infection, Latent Tuberculosis | Phase 1 | Recruiting | Brigham and Women's Hospital | 25 | 2024-11-15 | 2026-07-30 |
| 1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam Isoniazid, Rifapentine, Rifampicin - Tuberculosis Infection | Phase 3 | Withdrawn | Freundeskreis Für Internationale Tuberkulosehilfe e.V | 2024-11-01 | 2026-09-09 | |
| Short-course Rifamycin-based Regimens for Latent Tuberculosis in Patients With End-stage Kidney Disease Rifampicin plus Isoniazid, Rifapentine plus Isoniazid, Rifampicin alone - Latent Tuberculosis, Kidney Failure | Phase 4 | Unknown | Miguel Santín | 225 | 2024-04-20 | 2024-03-15 |
| ThiPhiSA: New Pathways to Prevention From Community TB Screening in South Africa Community-delivered TB preventive therapy (TPT) - 3 months weekly isoniazid plus rifapentine (3HP), Clinic-link TPT - Tuberculosis, HIV I Infection | Not applicable | Completed | University of Washington | 301 | 2024-02-20 | 2026-07-30 |
| Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV Rifapentine, Isoniazid - HIV Seropositivity, Pregnancy | Phase 1 / Phase 2 | Active not recruiting | The Aurum Institute NPC | 252 | 2024-01-17 | 2025-12-12 |
| A Novel Therapy With a 1-Month Ultrashort Regimen to Halt Progression From Latent Infection to Active Tuberculosis Among Close Contacts (The TB-YOUTH Study) isoniazid and rifapentine, Rifampin and Isoniazid - Tuberculosis, Latent Tuberculosis | Phase 3 | Recruiting | Huashan Hospital | 3520 | 2023-09-01 | 2026-07-14 |
| Optimizing(O) RIfapentine-based(RI) Regimen and shortENing(EN) the Treatment of Drug-sensitive Tuberculosis(T) Short Regimen with Rifapentine 10mg/kg, Standardized Regimen, Short Regimen with Rifapentine 15mg/kg - Tuberculosis, Pulmonary | Phase 2 / Phase 3 | Recruiting | Huashan Hospital | 2442 | 2023-01-13 | 2023-12-11 |
| Sitafloxacin-containing Regimens for Shortening Tuberculosis Treatment Sitafloxacin, SMZ/TMP, Rifampin - Tuberculosis, Pulmonary | Phase 3 | Unknown | First Affiliated Hospital of Zhejiang University | 620 | 2022-10-01 | 2022-07-12 |
| One-month Latent Tuberculosis Treatment for Renal Transplant Candidates 1 month Rifapentine, Isoniazid and Vitamin B6 - Latent Tuberculosis, End Stage Renal Disease | Phase 4 | Active not recruiting | Rutgers, The State University of New Jersey | 25 | 2022-07-01 | 2026-01-21 |
| Preventive Treatment Of Latent Tuberculosis Infection In People With Diabetes Mellitus Isoniazid and Rifapentine (INH-RPT), Placebo - Diabetes Mellitus, Tuberculosis | Phase 3 | Unknown | Dr. Nyanda Elias Ntinginya | 3000 | 2022-06-17 | 2023-03-29 |
| Ultra Curto (Ultra Short) TB Prevention Therapy Rifapentine 600 mg and INH 300 mg, Rifapentine 900 mg and INH 900 mg - Tuberculosis | Phase 4 | Completed | Johns Hopkins University | 531 | 2022-03-24 | 2025-06-19 |
| Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study Rifapentine, Rifampicin, Isoniazid - HIV, Tuberculosis | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 104 | 2021-11-05 | 2026-07-08 |
| Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals Dolutegravir (DTG), Isoniazid (INH), Rifapentine (RPT) - HIV Infection, LTBI | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 37 | 2021-02-27 | 2024-09-19 |
Showing 20 of 60. Sign in to see all of them.
Tuberculosis (30) · Latent Tuberculosis (19) · Tuberculosis, Pulmonary (9) · HIV Infections (5) · Acquired Immunodeficiency Syndrome (3) · Diabetes Mellitus (2) · AIDS-Related Opportunistic Infections (1) · Bacteremia (1) · Behavior, Addictive (1) · Breast Feeding (1) · HIV Seropositivity (1) · Hepatitis (1) · Infections (1) · Infertility, Female (1) · Kidney Failure, Chronic (1)
Centers for Disease Control and Prevention (11) · National Institute of Allergy and Infectious Diseases (NIAID) (8) · Johns Hopkins University (7) · Huashan Hospital (5) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · National Taiwan University Hospital (2) · The Aurum Institute NPC (2) · Aarhus University Hospital (1) · Anderson Clinical Research (1) · Brigham and Women's Hospital (1) · Dr. Nyanda Elias Ntinginya (1) · First Affiliated Hospital of Zhejiang University (1) · Freundeskreis Für Internationale Tuberkulosehilfe e.V (1) · Global Alliance for TB Drug Development (1) · Julio Ramirez (1)
United States (24) · South Africa (15) · Uganda (10) · Brazil (9) · Canada (9) · China (8) · Haiti (8) · Zimbabwe (8) · Thailand (7) · Malawi (6) · Vietnam (6) · India (5) · Kenya (5) · Botswana (4) · Indonesia (4)
Susan Dorman, MD (6) · Dick Menzies, MD (3) · Richard Chaisson, MD (3) · Marc Weiner, MD (2) · Robert Belknap, MD (2) · Susan Swindells, MBBS (2) · Timothy Sterling, MD (2) · Adeeba Kamarulzaman, MBBS (1) · Adrienne E Shapiro, MD, PhD (1) · Amber Robinson, PhD (1) · Andrey S Borisov, MD, MPH (1) · Anneke Hesseling, MD (1) · Anthony Podany, PharmD (1) · Avy Violari, MD (1) · Christian Wejse, MD PHD (1)
PMID 22150035, PMID 25904367, PMID 27243774, PMID 29393655, PMID 40326358, PMID 12045127, PMID 15276398, PMID 15840453, PMID 16141439, PMID 16574936, PMID 18419884, PMID 19588358, PMID 19656705, PMID 20610636, PMID 21732833, PMID 22530208, PMID 22850121, PMID 24343893, PMID 24614383, PMID 25489785, PMID 25512422, PMID 25580725, PMID 25824215, PMID 26082504, PMID 26260821, PMID 26951571, PMID 27010173, PMID 27159505, PMID 27268103, PMID 28087928, PMID 28406884, PMID 29114781, PMID 30029896, PMID 30102705, PMID 30865794, PMID 31414121, PMID 31690107, PMID 31770617, PMID 31981713, PMID 32553881, PMID 32815870, PMID 33374006, PMID 33508224, PMID 33713841, PMID 33794353, PMID 33951066, PMID 33951360, PMID 34042560, PMID 34252302, PMID 34323955
R01AI048526 (1), R01DA041271 (1), R21AI179276 (1), U01AI152961 (1)