164 completed, 43 unknown, 27 recruiting, 11 active not recruiting. 133 Not applicable, 32 Phase 3, 29 Phase 2, 15 Phase 1, 15 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FASD Prevention R33 Intervention, Usual Care - Alcohol and Tobacco/Cannabis Use | Phase 2 | Not yet recruiting | Philadelphia College of Osteopathic Medicine | 184 | 2027-02-01 | 2026-09-18 |
| The ACT-PrEP Study POC STI testing, CBC, and partner self-testing to improve PrEP uptake and persistence among pregnant and postpartum women., Standard of Care - HIV, PrEP | Not applicable | Not yet recruiting | University of California, Los Angeles | 120 | 2026-10-02 | 2026-10-09 |
| Intervention Development for Syndemics Among PWH in SA Cognitive Behavioral Therapy for Syndemics and Adherence (CBT-SA) - HIV Infections | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-09-15 | 2026-09-09 |
| Pilot Study of Prenatal Choline Supplementation Placebo, Choline bitartrate - Brain Development, Choline Nutrition | Phase 2 | Recruiting | Wayne State University | 50 | 2026-07-08 | 2026-07-14 |
| Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis Targeted sequencing using the GenoScreen Deeplex assay - Tuberculosis, Multidrug-Resistant | Not applicable | Not yet recruiting | University of Cape Town | 280 | 2026-06-01 | 2026-05-06 |
| Implementing Depression and Adherence Treatment Core Implementation Strategies, Enhanced Implementation Strategies - Depression, HIV | Not applicable | Recruiting | University of Miami | 10 | 2026-05-20 | 2026-09-21 |
| Protecting Against Lenacapavir Misinformation With Young Women in Gauteng, South Africa ( PROTECT-L) Diabetes information, Enhanced inoculation message - Misinformation, Lenacapavir | Not applicable | Recruiting | University of Pennsylvania | 1500 | 2026-05-19 | 2026-10-06 |
| The Coach Mpilo Study: Evaluation of a Peer-led Intervention to Promote Engagement in HIV Care for Men Living With HIV Coach Mpilo - HIV | Not applicable | Not yet recruiting | University of Cape Town | 800 | 2026-05-11 | 2026-05-11 |
| Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis Therapeutic Drug Monitoring for Linezolid - Rifampin-resistant Tuberculosis, Drug-resistant Tuberculosis | Not applicable | Recruiting | Albert Einstein College of Medicine | 280 | 2026-04-07 | 2026-05-04 |
| Implementation Study With Embedded RCT of a Digital System of Parenting Support Within Government Services in South Africa Module 1 - Improve My Relationship with My Teen/Child, Module 2 - Keep My Child/Teen Safe and Healthy - Program Effectiveness, Program Implementation | Not applicable | Active not recruiting | University of Cape Town | 4961 | 2026-02-02 | 2026-09-10 |
| Choice-Based Support for Adults Starting or Restarting Antiretroviral Therapy in Cape Town, South Africa In-person group support, WhatsApp group support, AI coach - HIV Care Loss to Followup | Not applicable | Not yet recruiting | University of Cape Town | 140 | 2026-02-01 | 2026-02-27 |
| What Works to Prevent Violence - Malawi Moyo Olemekeza SASA! Together, MO - Intimate Partner Violence (IPV), Earning Outcomes | Not applicable | Recruiting | George Washington University | 1700 | 2025-10-15 | 2026-04-03 |
| Mentor Moms+ Study MM+, Enhanced HIV attention control (eSOC) - HIV, Alcohol Consumption | Not applicable | Recruiting | University of California, Los Angeles | 100 | 2025-09-01 | 2026-07-02 |
| Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC). Prematurity; Extreme, Prematurity; Decision Support | Recruiting | Imperial College London | 90 | 2025-08-08 | 2026-03-30 | |
| Protecting Against HIV Vaccine Misinformation With Adolescent Girls and Young Women in South Africa Enhanced inoculation message, Nutrition information - Misinformation, HIV Vaccine | Not applicable | Active not recruiting | University of Pennsylvania | 2163 | 2025-07-24 | 2026-09-24 |
| TANDem-2: Closing the Gap to Interventions for TAND Well-Beans for Caregivers Program - Adult Caregivers of Individuals With TSC, Tuberous Sclerosis Complex (TSC) | Not applicable | Enrolling by invitation | Vrije Universiteit Brussel | 30 | 2025-07-15 | 2025-09-22 |
| The South African Collaborative Surgical Outcomes Study (SACSOS) Public or Private Sector Patients - Postoperative Complications | Not yet recruiting | Sefako Makgatho Health Sciences University | 1000 | 2025-06-01 | 2025-05-23 | |
| Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING PUMA) POC urine assay informed enhanced ART adherence counselling for viral suppression - ART Adherence | Not applicable | Recruiting | University of California, San Francisco | 500 | 2025-05-08 | 2026-07-20 |
| Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa Brief CBT-Based Intervention, Enhanced Treatment as Usual - Depression, Posttraumatic Stress Disorder | Not applicable | Recruiting | Boston University Charles River Campus | 118 | 2025-04-17 | 2026-07-17 |
| Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention Rifapentine, Dolutegravir - Pediatric HIV Infection, Latent Tuberculosis | Phase 1 | Recruiting | Brigham and Women's Hospital | 25 | 2024-11-15 | 2026-07-30 |
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Tuberculosis (45) · Acquired Immunodeficiency Syndrome (29) · HIV Infections (24) · Depression (11) · Malaria (11) · COVID-19 (8) · Hypertension (7) · Obesity (7) · Sexually Transmitted Diseases (7) · Tuberculosis, Multidrug-Resistant (7) · Tuberculosis, Pulmonary (7) · Breast Feeding (6) · Latent Tuberculosis (6) · Psychological Well-Being (6) · Disease (5)
Isoniazid (10) · Rifampin (10) · Standard of Care (6) · dolutegravir (6) · Pyrazinamide (5) · Artemether, Lumefantrine Drug Combination (4) · Ethambutol (4) · Linezolid (4) · MVA 85A (4) · rifapentine (4) · Artesunate (3) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (3) · Levofloxacin (3) · Ritonavir (3) · Tenofovir (3)
South Africa (215) · Uganda (11) · Zambia (10) · Zimbabwe (10) · United States (9) · Mozambique (8) · Nigeria (8) · Kenya (7) · Malawi (7) · India (6) · United Kingdom (6) · Sudan (5) · Tanzania (5) · Brazil (4) · Pakistan (4)
Adriana Baban, Prof. (3) · Catherine Ward, PhD (3) · Catherine Ward, Prof. (3) · Elaine J Abrams, MD (3) · Frances Gardner, Prof. (3) · Galina Lesco, Dr. (3) · Graeme Meintjes, PhD (3) · Heather Foran, Prof. (3) · Jamie Lachman, Dr. (3) · Judy Hutchings, Prof. (3) · Karen Barnes, MBChB (3) · Karen Sliwa, PhD (3) · Keertan Dheda, MBChB, PhD (3) · Marija Raleva, Prof. (3) · Rosanne Jocson, PhD (3)
PMID 34418380, PMID 39154169, PMID 19558654, PMID 22998715, PMID 25466778, PMID 26693728, PMID 28063795, PMID 29306587, PMID 30174920, PMID 30773459, PMID 32813276, PMID 34022988, PMID 34085132, PMID 34287756, PMID 35097151, PMID 35138678, PMID 36947792, PMID 37795521, PMID 37988391, PMID 11588210, PMID 15075545, PMID 15325446, PMID 15602021, PMID 16141439, PMID 16264158, PMID 16574936, PMID 16757089, PMID 17046859, PMID 17085459, PMID 17463418, PMID 18032943, PMID 18582195, PMID 19008268, PMID 19357737, PMID 19693024, PMID 19886982, PMID 20095074, PMID 20336078, PMID 20453627, PMID 20678190, PMID 20706107, PMID 20932805, PMID 20934212, PMID 21173675, PMID 21460373, PMID 21606542, PMID 21610487, PMID 21868369, PMID 21947399, PMID 22281831
2017 (1), 4UH3HD096926-03 (1), K01MH112443 (1), K01MH118072 (1), K01TW011187 (1), K23DA041901 (1), K23MH131438 (1), K43TW011442 (1), K43TW011943 (1), R01AI045468 (1), R01AI055359 (1), R01AI075603 (1), R01AI119037 (1), R01AI122300 (1), R01AI143340 (1)