6 completed, 4 unknown, 2 terminated, 1 withdrawn. 13 Phase 2, 6 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 6, Unknown 4, Terminated 2, Withdrawn 1 |
| Phase 1 | 6 | Completed 3, Unknown 2, Terminated 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Fractures, Ununited: new trials by email Literature Review of Fractures, Ununited trials Research Report on Fractures, Ununited
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adipose Tissue Derived Stromal Vascular Fraction (SVF) Application in Treatment of Long Bones Nonunion autologous adipose tissue derived stromal vascular fraction (SVF) - Nonunion of Fracture | Phase 1 / Phase 2 | Completed | Dr. Himanshu Bansal Foundation | 11 | 2019-11-10 | 2022-08-02 |
| Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs) Transplantation of autologous MSCs in nonunion fracture, Transplantation of allogeneic MSCs in nonunion fracture - Pseudoarthrosis of Bone, Pseudarthrosis | Phase 1 / Phase 2 | Unknown | Instituto Venezolano de Investigaciones Cientificas | 30 | 2018-01-30 | 2023-10-31 |
| Treatment of Nonunion of Limb Fracture With Human Amniotic Epithelial Cells（hAECs） Human Amniotic Epithelial Cells, debridement - Nonunion Fracture | Phase 1 / Phase 2 | Unknown | Shanghai East Hospital | 36 | 2017-12-01 | 2017-06-05 |
| A Clinical Trial to Assess the Effect of HC-SVT-1001 and HC-SVT-1002 in the Surgical Treatment of Atrophic Pseudarthrosis of Long Bones (Bonecure) HC-SVT-1001(initial protocol); HC-SVT-1002 (protocol amendment) - Pseudoarthrosis | Phase 2 | Completed | Salvat | 12 | 2015-11-10 | 2021-03-17 |
| Autologous BM-MSC Transplantation in Combination With Platelet Lysate (PL) for Nonunion Treatment Percutaneous injection - Bone Fracture | Phase 2 / Phase 3 | Unknown | Royan Institute | 60 | 2015-06-01 | 2015-10-30 |
| Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery - Atrophic Nonunion of Fracture | Phase 1 / Phase 2 | Completed | Banc de Sang i Teixits | 19 | 2014-11-20 | 2021-04-12 |
| Study on Allogeneic Osteoblastic Cells Implantation in Rescue Interbody Fusion ALLOB® - Failed Lumbar Fusion | Phase 2 | Terminated | Bone Therapeutics S.A | 6 | 2014-09-01 | 2020-06-11 |
| Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold surgical treatment of non union with mesenchymal stem cells with BMP2 within a 3-D tissue engineered scaffold - Nonunion of Fracture | Phase 2 | Unknown | Emdadi Kamyab Hospital | 18 | 2013-07-01 | 2013-10-09 |
| The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital injection the mesenchymal stem cell in non union site - Nonunion Fracture | Phase 2 | Completed | Emdadi Kamyab Hospital | 19 | 2013-01-01 | 2013-12-30 |
| Treatment of Atrophic Nonunion Fractures by Autologous Mesenchymal Stem Cell Percutaneous Grafting Mesenchymal Stem Cells, Culture medium without MSC. - Nonunion Fracture | Phase 2 | Withdrawn | University of Liege | 2012-11-01 | 2021-05-12 | |
| Clinical Trial Based on the Use of Mononuclear Cells From Autologous Bone Marrow in Patients With Pseudoarthrosis ABM seeded onto a porous TCP and DBM, autologous bone graft - Pseudoarthrosis | Phase 2 | Completed | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | 5 | 2011-04-01 | 2017-03-30 |
| Treatment of Atrophic Nonunion by Preosteoblast Cells percutaneous autologous preosteoblast cells implantation - Pseudarthrosis, Fractures, Ununited | Phase 1 / Phase 2 | Completed | Jean-Philippe Hauzeur | 30 | 2008-11-01 | 2012-02-23 |
| Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures. Fracture surgery, Cultured Bone Marrow Tissue - Fracture, Ununited, Pseudarthrosis | Phase 1 / Phase 2 | Terminated | Vericel Corporation | 36 | 2003-10-01 | 2021-05-11 |
Pseudarthrosis (7) · Fractures, Bone (3) · Callosities (1)
Wounds and Injuries (13) · Fractures, Bone (10) · Keratosis (1) · Skin Diseases (1) · Skin and Connective Tissue Diseases (1)
Administration, Cutaneous (1) · Clinical Protocols (1) · Culture Media (1) · Debridement (1) · Dopamine beta-Hydroxylase (1) · Surgical Procedures, Operative (1)
Emdadi Kamyab Hospital (2) · Banc de Sang i Teixits (1) · Bone Therapeutics S.A (1) · Dr. Himanshu Bansal Foundation (1) · Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia (1) · Instituto Venezolano de Investigaciones Cientificas (1) · Jean-Philippe Hauzeur (1) · Royan Institute (1) · Salvat (1) · Shanghai East Hospital (1) · University of Liege (1) · Vericel Corporation (1)
Belgium (3) · Iran (3) · Spain (3) · China (1) · India (1) · United States (1) · Venezuela (1)
Enrique Jimenez, MD (1) · Fernando Granell, MD, PhD (1) · Hamid Gourabi, PhD (1) · James Goulet, MD (1) · Jean Philippe Hauzeur, MD, PhD (1) · Jean-Philippe Hauzeur, MD, PhD (1) · Jose E Cardier Montalvo, MD, PhD (1) · Luis Meseguer Olmo, MD,PhD (1) · Matthew Jimenez, MD (1) · Mohammad Razi, MD (1) · Mohsen Emadedin, MD (1) · Narges Labibzadeh, MD (1) · Nasser Aghdami, MD,PhD (1)
PMID 16557516, PMID 16619257, PMID 27388241, PMID 27538760, PMID 38789992