175 completed, 50 unknown, 26 recruiting, 19 terminated. 292 Phase 1, 117 Phase 2.
Follow Fibrosis: new trials by email Literature Review of Fibrosis trials Research Report on Fibrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males Fulvestrant, Anastrozole (ARIMIDEX™) - Inguinal Hernia Unilateral, Inguinal Hernia Bilateral | Phase 1 | Recruiting | Northwestern University | 30 | 2026-10-02 | 2026-10-06 |
| Umbilical Cord Mesenchymal Stem Cell Therapy for Biliary Atresia Umbilical Cord-Mesenchymal Stem Cells (UC-MSC), Kasai Portoenterostomy - Biliary Atresia, Kasai Operation | Phase 1 | Recruiting | Dr Cipto Mangunkusumo General Hospital | 40 | 2026-09-01 | 2026-09-09 |
| Phase I/II Trial of Human Umbilical Cord Mesenchymal Stromal Cells for UDCA-Refractory Primary Biliary Cholangitis Standard background therapy, Placebo, hUC-MSC Dose Level 1 - Primary Biliary Cholangitis | Phase 1 / Phase 2 | Not yet recruiting | Beijing 302 Hospital | 68 | 2026-08-31 | 2026-08-31 |
| FAPI PET Imaging - An Exploratory Study [18F]FAPI-74 PET/CT - Thyroid Pathology, Head and Neck Cancer (H&N) | Phase 1 / Phase 2 | Not yet recruiting | Martin Huellner | 770 | 2026-08-01 | 2026-07-15 |
| Dose-Escalation Study of Artesunate Patients With IPF Artesuante, Placebo capsules - Idiopathic Pulmonary Fibrosis | Phase 1 | Recruiting | Joseph C. Wu | 15 | 2026-08-01 | 2026-08-11 |
| A Clinical Study on the Safety and Efficacy of Wide-Band Ultrasound Combined With Traditional Chinese Medicine Preparations in the Prevention and Treatment of Keloids Wide-Band Ultrasound, traditional Chinese medicine - Keloid | Phase 1 / Phase 2 | Not yet recruiting | Fujian Medical University Union Hospital | 120 | 2026-08-01 | 2026-07-01 |
| Scar Remodeling After Burn Injury Using Allogeneic Adipose-derived Stromal Cells Allogeneic adipose-Derived Mesenchymal Stromal Cells, Cryostor CS10 + Ringers Lactate - Scar Conditions and Fibrosis of Skin, Scar Quality Assessment and Safety | Phase 1 / Phase 2 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 39 | 2026-04-16 | 2026-06-09 |
| Study on the Drug Interactions of HRS-9813, Pirfenidone and Nintedanib in Healthy Subjects HRS-9813 Capsule, Nintedanib Soft Capsules, Pirfenidone Tablets - Pulmonary Fibrosis | Phase 1 | Completed | Guangdong Hengrui Pharmaceutical Co., Ltd | 20 | 2026-04-04 | 2026-09-21 |
| Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Advanced Hepatocellular Carcinoma, Cirrhosis | Phase 1 / Phase 2 | Recruiting | Devalingam Mahalingam | 59 | 2026-03-30 | 2026-10-23 |
| Study of Hydroxynidone Capsules in Patients With Hepatic Impairment and Matched Healthy Controls Hydronidone capsules - Liver Fibrosis | Phase 1 | Completed | Beijing Continent Pharmaceutical Co, Ltd. | 30 | 2026-03-25 | 2026-08-13 |
| Safety Evaluation of MSC-based Therapy for Liver Cihcrosis Treatment Umbilical cord mesenchymal stem cell-derived extracellular vesicles - Liver Cirrhosis | Phase 1 | Not yet recruiting | Vinmec Research Institute of Stem Cell and Gene Technology | 12 | 2026-03-15 | 2026-03-16 |
| QTc Assessment in a Single-Dose Study of Hydronidone Capsules Hydronidone, Placebo - Hepatic Fibrosis | Phase 1 | Completed | Beijing Continent Pharmaceutical Co, Ltd. | 48 | 2025-12-30 | 2026-08-13 |
| The Phase Ⅰd Clinical Trial of Hydronidone Capsules Hydronidone capsules, Placebo capsules - Liver Fibrosis | Phase 1 | Completed | Beijing Continent Pharmaceutical Co, Ltd. | 138 | 2025-12-24 | 2026-09-21 |
| Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases Injection of 68Ga-NI-FAPI - Tumor, Cardiovascular Diseases | Phase 1 / Phase 2 | Recruiting | Peking Union Medical College Hospital | 30 | 2025-12-17 | 2026-03-11 |
| Bioequivalence and Adhesion of a Rotigotine Patch in Healthy Subjects Rotigotine Transdermal Delivery System (TDS) - Bioequivalence, Adhesion | Phase 1 | Completed | Amarin Technologies S.A.U. | 35 | 2025-12-04 | 2026-08-19 |
| Nucleoside Therapy in Patients With Telomere Biology Disorders deoxycytidine, deoxythymidine - Telomere Biology Disorders, Dyskeratosis Congenita | Phase 1 | Recruiting | Suneet Agarwal | 36 | 2025-09-29 | 2026-08-04 |
| Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver Disease Saroglitazar Magnesium 1 mg - Cholestatic Liver Disease | Phase 1 | Recruiting | Zydus Therapeutics Inc. | 6 | 2025-08-05 | 2026-09-14 |
| The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial Commensal Bacteria Strains - Liver Diseases, Liver Failure | Phase 1 | Recruiting | University of Chicago | 24 | 2025-08-04 | 2025-11-04 |
| Clinical Outcomes of Early Kasai Surgery With Umbilical Cord MSCs in Biliary Atresia Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs), Kasai Portoenterostomy - Biliary Atresia, Kasai Portoenterostomy | Phase 1 | Not yet recruiting | Universitas Diponegoro | 14 | 2025-06-17 | 2025-06-08 |
| CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection Ex Vivo CRISPR-Cas9 Gene Editing of Donor Liver - Liver Diseases, Liver Cancer | Phase 1 / Phase 2 | Recruiting | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | 90 | 2025-06-01 | 2025-07-08 |
Showing 20 of 292. Sign in to see all of them.
Liver Cirrhosis (93) · Cicatrix (43) · Pulmonary Fibrosis (34) · Liver Cirrhosis, Biliary (26) · Keloid (19) · Non-alcoholic Fatty Liver Disease (15) · Idiopathic Pulmonary Fibrosis (14) · Liver Diseases (12) · Carcinoma, Hepatocellular (10) · Tissue Adhesions (10) · Cicatrix, Hypertrophic (8) · Fatty Liver (8) · Hepatitis C (8) · End Stage Liver Disease (7)
Pathological Conditions, Signs and Symptoms (292) · Pathologic Processes (291) · Digestive System Diseases (159) · Liver Diseases (140) · Respiratory Tract Diseases (36) · Lung Diseases, Interstitial (34) · Lung Diseases (32) · Bile Duct Diseases (30) · Biliary Tract Diseases (30) · Skin and Connective Tissue Diseases (29) · Cicatrix (28) · Cholestasis, Intrahepatic (26) · Liver Cirrhosis (26) · Cholestasis (24)
TGFB3 protein, human (9) · NRL972 (5) · Ursodeoxycholic Acid (5) · ICG 001 (4) · Magnetic Resonance Spectroscopy (4) · Rituximab (4) · Saline Solution (4) · Fecal Microbiota Transplantation (3) · Sodium Chloride (3) · Triamcinolone Acetonide (3) · hydronidone (3) · pirfenidone (3) · 68Ga-FAPI (2) · Cell- and Tissue-Based Therapy (2) · Congresses as Topic (2)
Renovo (11) · AstraZeneca (6) · Bristol-Myers Squibb (6) · GlaxoSmithKline (5) · Norgine (5) · Beijing 302 Hospital (4) · Mayo Clinic (4) · National Cancer Institute (NCI) (4) · Peking Union Medical College Hospital (4) · Air Force Military Medical University, China (3) · Baermed (3) · Beijing Continent Pharmaceutical Co, Ltd. (3) · Cascade Pharmaceuticals, Inc (3) · Galecto Biotech AB (3) · Kiminori Kimura, MD (3)
United States (112) · China (47) · United Kingdom (26) · Germany (9) · Australia (8) · Canada (7) · Italy (7) · Japan (7) · Spain (6) · Indonesia (5) · Iran (5) · South Korea (5) · Belgium (4) · Brazil (4) · Bulgaria (4)
Jonathan Duncan (4) · Kiminori Kimura, MD (4) · Daiming Fan (3) · Michael J Davies (3) · Zahariy Krastev, MD (3) · Hamid Gourabi, PhD (2) · Hossein Baharvand, PhD (2) · Jared Jagdeo, MD, MS (2) · Jasmohan S Bajaj, MD (2) · Jasmohan S Bajaj, MD, MSc (2)
PMID 19362676, PMID 10102814, PMID 10415784, PMID 10655252, PMID 12563677, PMID 14719037, PMID 15663512, PMID 17181919, PMID 17694216, PMID 17903050, PMID 18068515, PMID 18097874, PMID 18346996, PMID 18459515, PMID 18668653, PMID 19146602, PMID 19397687, PMID 19453649, PMID 19998041, PMID 21131395, PMID 21194255, PMID 21233083, PMID 21751289, PMID 21810549, PMID 22028728, PMID 22282526, PMID 22545014, PMID 22731679, PMID 23077622, PMID 23220074, PMID 23453404, PMID 23565181, PMID 23590233, PMID 24074360, PMID 24561556, PMID 24835895, PMID 24876849, PMID 25329189, PMID 25485805, PMID 25667206, PMID 25906706, PMID 26006200, PMID 26143343, PMID 26336510, PMID 26867177, PMID 26869678, PMID 26972567, PMID 27148676, PMID 27192671, PMID 27484782
2016 (2), 2018 (2), P30CA060553 (2), 2009 (1), 2014 (1), I01CX002516 (1), M01RR000051 (1), N01CN00035 (1), N01CN00042 (1), P01CA108671 (1), P30CA015083 (1), P30CA016672 (1), P30DK034989 (1), R01AA029398 (1), R01CA263776 (1)