174 completed, 57 unknown, 38 recruiting, 33 terminated. 347 Phase 3, 75 Phase 2.
Follow Fibrosis: new trials by email Literature Review of Fibrosis trials Research Report on Fibrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients IP1 control cream (Vehicle base), IP2 - 0.5% w/w FS2 - Burn Scar, Burn Wound | Phase 2 / Phase 3 | Recruiting | Birch BioMed Inc | 70 | 2027-03-01 | 2026-09-30 |
| Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis BMS-986278 - Pulmonary Fibrosis | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2380 | 2026-12-16 | 2026-10-30 |
| Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year - Schistosomiasis, Schistosoma Mansoni | Phase 2 / Phase 3 | Not yet recruiting | Rhode Island Hospital | 600 | 2026-11-01 | 2026-08-12 |
| Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) ALN-CIDEB, Placebo - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD | Phase 3 | Recruiting | Regeneron Pharmaceuticals | 1500 | 2026-10-28 | 2026-11-05 |
| J-LINX: Japan LINerixibat eXtension Study Linerixibat - Pruritus | Phase 3 | Not yet recruiting | GlaxoSmithKline | 40 | 2026-10-09 | 2026-10-06 |
| Oral or Topical Catechins for Radiation Dermatitis Epicatechin, Epigallocatechin Gallate (EGCG), Microcrystalline Cellulose NF (placebo) - Radiation Dermatitis Acute, Radiation Dermatitis | Phase 3 | Enrolling by invitation | CARLOS FRANCISCO SAAVEDRA GARCIA | 162 | 2026-10-01 | 2026-09-11 |
| A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier) Mosliciguat, Placebo, Dry Powder Inhaler - Pulmonary Hypertension, Interstitial Lung Disease | Phase 3 | Recruiting | Pulmovant, Inc. | 376 | 2026-08-31 | 2026-09-11 |
| Study of Saroglitazar Magnesium for PBC Patients With Incomplete Response or Intolerant to UDCA Therapy Saroglitazar Magnesium 1 mg, Placebo - Primary Biliary Cholangitis | Phase 3 | Recruiting | Zydus Therapeutics Inc. | 90 | 2026-08-11 | 2026-09-15 |
| Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy 2-L PEG plus bisacodyl plus 3-day low fibre diet, 2-L PEG plus 1-day low fibre diet - Cirrhosis, Bowel Preparation | Phase 3 | Not yet recruiting | Hospital do Divino Espírito Santo de Ponta Delgada | 252 | 2026-08-01 | 2026-06-25 |
| A Pivotal Clinical Study to Investigate the Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH) Efimosfermin alfa, Placebo - Metabolic Dysfunction-associated Steatohepatitis | Phase 3 | Recruiting | GlaxoSmithKline | 1740 | 2026-07-22 | 2026-11-05 |
| A Study to Investigate Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH) Efimosfermin alfa, Placebo - Metabolic Dysfunction-associated Steatohepatitis | Phase 3 | Recruiting | GlaxoSmithKline | 380 | 2026-07-22 | 2026-11-05 |
| Apixaban to Prevent Decompensation of Early Liver Cirrhosis Trial Apixaban 2.5 mg twice daily, Placebo - Liver Cirrhosis | Phase 3 | Not yet recruiting | University College, London | 1142 | 2026-07-15 | 2026-07-24 |
| Trial to Evaluate the Efficacy and Safety of LYT-100 (Deupirfenidone) Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (IPF) Deupirfenidone, Pirfenidone (PFD) - Idiopathic Pulmonary Fibrosis (IPF) | Phase 3 | Recruiting | PureTech | 1100 | 2026-06-26 | 2026-10-23 |
| Topical Cryotherapy and Keloid/Hypertrophic Scars Cryotherapy with liquid nitrogen, Intralesional Triamcinolone 10 mg/ml - Keloid Scars, Hypertrophic Scars | Phase 3 | Recruiting | Sonal Choudhary | 30 | 2026-06-10 | 2026-06-12 |
| Bumetanide vs. Furosemide in Cirrhosis Bumetanide, Furosemide - Cirrhosis | Phase 3 | Recruiting | Stacy Johnson | 500 | 2026-06-03 | 2026-06-16 |
| Can Aspirin Reduce the Risk of HCC in Cirrhosis: The AspiRe HCC Trial Low-dose aspirin, Placebo Comparator - Liver Cirrhosis | Phase 3 | Not yet recruiting | Curtin University | 890 | 2026-06-01 | 2026-04-14 |
| Long-Term Study to Evaluate the Safety and Efficacy in Participants With Primary Biliary Cholangitis of Saroglitazar Magnesium-V on Clinical Outcomes Saroglitazar magnesium 1 mg, Placebo - Primary Biliary Cholangitis | Phase 3 | Recruiting | Zydus Therapeutics Inc. | 386 | 2026-03-24 | 2026-08-04 |
| Albumin in Acute Variceal Bleeding Albumin - Acute Variceal Bleeding, Cirrhosis | Phase 3 | Not yet recruiting | King George's Medical University | 60 | 2026-03-01 | 2026-02-09 |
| A Phase IIIc Clinical Study to Evaluate the Long-term Treatment of Hydronidone Capsules for Liver Fibrosis in Patients With Chronic Hepatitis B. Hydronidone (270mg), Hydronidone (Placebo Group) - Liver Fibrosis, Liver Fibrosis in Chronic Hepatitis B | Phase 3 | Not yet recruiting | Beijing Continent Pharmaceutical Co, Ltd. | 1208 | 2026-01-30 | 2026-02-17 |
| FIREFLY Trial: Fenofibrate Intervention---Randomized Evaluation in First-Line PBC Therapy Fenofibrate, UDCA (Ursodeoxycholic acid) - Primary Biliary Cholangitis (PBC) | Phase 3 | Recruiting | Xijing Hospital of Digestive Diseases | 132 | 2025-12-15 | 2026-11-02 |
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Liver Cirrhosis (98) · Liver Cirrhosis, Biliary (44) · Hepatitis C (36) · Pulmonary Fibrosis (36) · Ascites (27) · Hepatitis C, Chronic (26) · Cicatrix (23) · Hypertension, Portal (23) · Idiopathic Pulmonary Fibrosis (19) · Non-alcoholic Fatty Liver Disease (15) · Cicatrix, Hypertrophic (14) · Carcinoma, Hepatocellular (13) · Liver Diseases (13) · Esophageal and Gastric Varices (11)
Pathological Conditions, Signs and Symptoms (347) · Pathologic Processes (343) · Digestive System Diseases (216) · Liver Diseases (203) · Infections (60) · Virus Diseases (51) · Hepatitis (49) · RNA Virus Infections (49) · Blood-Borne Infections (48) · Communicable Diseases (48) · Hepatitis, Viral, Human (47) · Liver Cirrhosis (46) · Bile Duct Diseases (45) · Biliary Tract Diseases (45)
Ribavirin (19) · Propranolol (9) · Ursodeoxycholic Acid (9) · Fenofibrate (8) · Rifaximin (8) · Tolvaptan (8) · peginterferon alfa-2b (8) · pirfenidone (8) · Saline Solution (7) · Sodium Chloride (7) · Sofosbuvir (6) · Terlipressin (6) · dasabuvir (6) · ombitasvir (6) · paritaprevir (6)
Assistance Publique - Hôpitaux de Paris (12) · AbbVie (10) · Gilead Sciences (10) · Xijing Hospital of Digestive Diseases (10) · Merck Sharp & Dohme LLC (7) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (7) · Post Graduate Institute of Medical Education and Research, Chandigarh (6) · Tanta University (6) · GlaxoSmithKline (5) · University of Padova (5) · Ipsen (4) · Sherief Abd-Elsalam (4) · Zydus Therapeutics Inc. (4) · Beijing Continent Pharmaceutical Co, Ltd. (3) · Boehringer Ingelheim (3)
United States (108) · France (65) · Spain (50) · Italy (49) · China (48) · Germany (45) · Canada (44) · United Kingdom (44) · Belgium (34) · Mexico (30) · Australia (26) · South Korea (26) · Argentina (24) · Israel (24) · Poland (24)
Imre Noth, MD (3) · Sherief M. Abd-Elsalam, Consultant (3) · David N Herndon, MD (2) · David Ozog, MD (2) · Eric Bellissant, MD, PhD (2) · Eric Cohen, MD (2) · Fernando Martinez, MD (2)
PMID 27847279, PMID 28388260, PMID 35688625, PMID 21836029, PMID 26835133, PMID 31047956, PMID 33434107, PMID 36740893, PMID 37391667, PMID 37786277, PMID 17105757, PMID 21571362, PMID 22027579, PMID 22732511, PMID 24834811, PMID 24836310, PMID 25151571, PMID 25543678, PMID 25890798, PMID 26111071, PMID 26400368, PMID 26575258, PMID 26968970, PMID 27672117, PMID 27708114, PMID 28039616, PMID 28526798, PMID 30072107, PMID 30116539, PMID 30176872, PMID 30472023, PMID 30729456, PMID 30971229, PMID 31153107, PMID 31401786, PMID 31914963, PMID 32217654, PMID 33239000, PMID 33902584, PMID 37035316, PMID 37467180, PMID 42548365, PMID 10051462, PMID 10077078, PMID 10343514, PMID 10347106, PMID 11211893, PMID 11242330, PMID 11303974, PMID 11348456
2014 (8), 2016 (4), 2009 (3), 2023 (3), 2005 (2), 2019 (2), 2025 (2), U10HL080413 (2), 2004 (1), 2008 (1), 2015 (1), R01AI184979 (1), R01DK046580 (1), R01DK046602 (1), R01DK051523 (1)