24 completed, 4 unknown, 1 terminated, 1 withdrawn. 21 Phase 2, 13 Phase 1, 2 Not applicable, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Completed 18, Unknown 2, Terminated 1 |
| Phase 1 | 13 | Completed 12, Unknown 1 |
| Not applicable | 2 | Unknown 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prevascar in African Continental Group Scarring Prevascar 5ng, Prevascar 25ng, Prevascar 100ng - Scarring | Phase 1 | Unknown | Renovo | 56 | 2010-04-01 | 2011-02-10 |
| Adaprev in Digital Flexor Tendon Repair Adaprev - Tendon Injuries | Not applicable | Unknown | Renovo | 44 | 2009-09-01 | 2010-12-09 |
| A Trial to Compare the Efficacy of Two Formulations of Avotermin Against Placebo Juvista (Avotermin), RN1006 (Avotermin), Placebo - Scar Improvement | Phase 1 | Completed | Renovo | 84 | 2009-08-01 | 2010-12-09 |
| Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids Avotermin (Juvista), Placebo - Keloid | Phase 1 / Phase 2 | Completed | Renovo | 20 | 2009-02-01 | 2010-09-28 |
| Juvista in the Non-surgical Improvement of Existing Scars Juvista, Placebo - Scars | Not applicable | Withdrawn | Renovo | 40 | 2009-01-01 | 2010-03-09 |
| Juvista in Scar Revision Surgery of Disfiguring Scars Juvista (avotermin) - Cicatrix | Phase 3 | Completed | Renovo | 350 | 2008-12-01 | 2011-03-03 |
| Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Avotermin, placebo - Keloid | Phase 1 / Phase 2 | Completed | Renovo | 10 | 2008-07-01 | 2010-03-09 |
| Juvidex (Mannose-6-Phosphate) in Accelerating the Healing of Split Thickness Skin Graft Donor Sites Mannose-6-Phosphate (Juvidex), Mannose-6-Phophate (Juvidex), Placebo - Wound | Phase 1 / Phase 2 | Completed | Renovo | 195 | 2008-02-01 | 2009-01-06 |
| Pharmacogenomic Analysis of Samples From Subjects in Study RN1004-0082 Wound | Completed | Renovo | 195 | 2008-02-01 | 2009-01-06 | |
| Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Avotermin - Keloid | Phase 1 / Phase 2 | Completed | Renovo | 20 | 2007-06-01 | 2009-09-16 |
| Trial of Zesteem (Estradiol) in Healing of Split Thickness Skin Graft Donor Sites estradiol (Zesteem) - Burn, Trauma | Phase 3 | Completed | Renovo | 148 | 2007-01-01 | 2009-08-28 |
| Juvista (Avotermin) in Scars Following Varicose Vein Removal Avotermin - Varicose Veins, Cicatrix | Phase 2 | Completed | Renovo | 156 | 2006-11-01 | 2010-03-09 |
| Juvista (Avotermin) in Breast Reduction Surgery Scars Avotermin - Mammaplasty, Cicatrix | Phase 2 | Terminated | Renovo | 39 | 2006-10-01 | 2009-01-13 |
| Improvement in Scar Appearance Following Injection of Avotermin (Juvista) Into Skin Incisions Made in Healthy Men and Women Avotermin (Juvista), Placebo - Cicatrix | Phase 2 | Completed | Renovo | 78 | 2006-09-01 | 2008-03-06 |
| Scar-Improvement Efficacy and Safety of a Single Intradermal Injection of Avotermin (Juvista) Administered Following Full-Thickness Skin Incisions Avotermin, Placebo - Cicatrix | Phase 2 | Completed | Renovo | 39 | 2006-07-01 | 2008-03-04 |
| Juvista (Avotermin) in the Prevention or Improvement of Scar Appearance Following Scar Revision Surgery. Avotermin - Cicatrix | Phase 2 | Unknown | Renovo | 60 | 2006-05-01 | 2009-02-04 |
| Investigation Into the Scar Reduction Potential of Prevascar (Interleukin-10) Prevascar, Placebo - Cicatrix, Wound Healing | Phase 2 | Completed | Renovo | 175 | 2005-04-01 | 2009-09-25 |
| Investigation of the Efficacy of Zesteem in Accelerating Early Wound Healing Zesteem, Placebo - Cicatrix, Wound-healing | Phase 2 | Completed | Renovo | 44 | 2005-03-01 | 2009-09-25 |
| RN1001(Avotermin) in Scar Improvement Following Breast Augmentation Avotermin - Mammaplasty, Cicatrix | Phase 2 | Completed | Renovo | 63 | 2004-12-01 | 2008-08-14 |
| Investigation Into the Safety and Scar-improvement Efficacy of Intradermal Juvidex Dosed Once or Three Times Juvidex, Placebo - Cicatrix, Wound-healing | Phase 2 | Completed | Renovo | 102 | 2004-08-01 | 2009-09-25 |
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Cicatrix (22) · Keloid (3) · Wounds and Injuries (3) · Arrhythmogenic Right Ventricular Dysplasia, Familial, 1 (2) · Burns (1) · Nevus (1) · Tendon Injuries (1) · Varicose Ulcer (1) · Varicose Veins (1)
TGFB3 protein, human (21) · Transforming Growth Factor beta3 (5) · mannose-6-phosphate (3) · Estradiol (2) · Ltbp3 protein, zebrafish (2) · Interleukin-10 (1) · Standard of Care (1)
United Kingdom (27) · United States (4) · Latvia (3) · Germany (2) · Belgium (1) · Denmark (1) · France (1) · Hungary (1) · Italy (1) · Lithuania (1) · Poland (1) · Russia (1) · Spain (1)
Jonathan Duncan (6) · James Bush (3) · Jeremy Bond (3) · Michael J Davies (3) · James Bush, MBChB (2) · Jim Bush, MBChB. MRCS (2) · D A McGrouther, FRCS MD (1) · D A McGrouther, FRCS, MD (1) · David Whitby (1) · James Dr Bush, MBChB MRCS (1) · Jim Bush, MB ChB (1) · Jim Bush, MBChB (1) · John Hutchison, MBBS PhD (1) · Jonathan Duncan, BS BCh (1) · Jonathan Duncan, MB BCh (1)
PMID 19362676, PMID 21042116, PMID 21618480, PMID 21701333, PMID 29898959