10 completed, 3 terminated, 1 recruiting, 1 unknown. 16 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 10, Terminated 3, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 3 | Terminated 2, Completed 1 |
Follow Fibrosarcoma: new trials by email Literature Review of Fibrosarcoma trials Research Report on Fibrosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism Ersodetug - Tumor Hyperinsulinism (Tumor HI) | Phase 3 | Recruiting | Rezolute | 16 | 2025-04-16 | 2026-09-28 |
| Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma Brigimadlin, Ezabenlimab, Gemcitabine - Advanced Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma (UPS) | Phase 3 | Withdrawn | Boehringer Ingelheim | 2024-06-27 | 2024-07-17 | |
| Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Doxorubicin, Doxorubicin Hydrochloride, Ifosfamide - Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma | Phase 2 / Phase 3 | Completed | National Cancer Institute (NCI) | 140 | 2014-08-12 | 2026-06-17 |
| Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma doxorubicin hydrochloride, trabectedin, laboratory biomarker analysis - Sarcoma | Phase 2 / Phase 3 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 133 | 2011-05-01 | 2014-08-08 |
| Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer cyproheptadine hydrochloride, placebo - Cancer | Phase 3 | Terminated | University of South Florida | 22 | 2010-06-01 | 2015-07-02 |
| Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma doxorubicin hydrochloride, clinical observation, therapeutic conventional surgery - Adult Alveolar Soft-part Sarcoma, Adult Angiosarcoma | Phase 3 | Completed | Children's Oncology Group | 588 | 2007-02-05 | 2022-04-28 |
| Imatinib Mesylate Treatment of Patients With Malignant Peripheral Nerve Sheath Tumors imatinib mesylate - Malignant Peripheral Nerve Sheath Tumors | Phase 2 / Phase 3 | Terminated | Novartis Pharmaceuticals | 11 | 2006-05-01 | 2012-08-07 |
| Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma radiotherapy - Sarcoma | Phase 3 | Completed | Sheffield Teaching Hospitals NHS Foundation Trust | 216 | 2006-03-01 | 2021-03-18 |
| Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma doxorubicin hydrochloride, ifosfamide, adjuvant therapy - Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma | Phase 3 | Unknown | European Paediatric Soft Tissue Sarcoma Study Group | 250 | 2006-03-01 | 2013-08-12 |
| Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis conventional surgery, radiation therapy - Sarcoma | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 370 | 2004-08-01 | 2016-07-06 |
| Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma pegfilgrastim, doxorubicin hydrochloride, ifosfamide - Sarcoma | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 455 | 2003-04-01 | 2014-10-27 |
| Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma doxorubicin hydrochloride, ifosfamide - Sarcoma | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 780 | 1998-01-01 | 2012-01-20 |
| Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma doxorubicin hydrochloride, etoposide, ifosfamide - Sarcoma | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 340 | 1997-07-01 | 2013-09-17 |
| Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma filgrastim, doxorubicin hydrochloride, ifosfamide - Endometrial Cancer, Kidney Cancer | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 340 | 1996-04-01 | 2012-07-11 |
| Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma filgrastim, doxorubicin hydrochloride, ifosfamide - Endometrial Cancer, Kidney Cancer | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 350 | 1995-02-01 | 2014-08-08 |
| Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma dactinomycin, carboplatin, cyclophosphamide - Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma | Phase 3 | Completed | Societe Internationale d'Oncologie Pediatrique | 400 | 1995-01-01 | 2013-12-04 |
Liposarcoma (13) · Sarcoma (13) · Hemangiosarcoma (12) · Histiocytoma, Malignant Fibrous (11) · Neurofibrosarcoma (11) · Leiomyosarcoma (10) · Sarcoma, Synovial (10) · Hemangiopericytoma, Malignant (8) · Malignant mesenchymal tumor (6) · Sarcoma, Alveolar Soft Part (6) · Chondrosarcoma, Extraskeletal Myxoid (4) · Dermatofibrosarcoma (4) · Rhabdomyosarcoma (4) · Sarcoma, Endometrial Stromal (3)
Neoplasms by Histologic Type (16) · Neoplasms, Connective Tissue (16) · Neoplasms, Connective and Soft Tissue (16) · Neoplasms, Fibrous Tissue (16) · Neoplasms (14) · Neoplasms, Nerve Tissue (14) · Neoplasms, Adipose Tissue (13) · Neoplasms, Vascular Tissue (12) · Nervous System Diseases (12) · Nervous System Neoplasms (12) · Peripheral Nervous System Neoplasms (12) · Histiocytoma (11) · Neurofibroma (11) · Neuromuscular Diseases (11) · Peripheral Nervous System Diseases (11)
Doxorubicin (9) · Ifosfamide (9) · Radiotherapy (7) · Chemotherapy, Adjuvant (3) · Etoposide (2) · Filgrastim (2) · Neoadjuvant Therapy (2) · Brachytherapy (1) · Carboplatin (1) · Combined Modality Therapy (1) · Cyclophosphamide (1) · Cyproheptadine (1) · Dactinomycin (1) · Diathermy (1) · Docetaxel (1)
European Organisation for Research and Treatment of Cancer - EORTC (6) · Alliance for Clinical Trials in Oncology (1) · Boehringer Ingelheim (1) · Children's Oncology Group (1) · European Paediatric Soft Tissue Sarcoma Study Group (1) · National Cancer Institute (NCI) (1) · Novartis Pharmaceuticals (1) · Rezolute (1) · Sheffield Teaching Hospitals NHS Foundation Trust (1) · Societe Internationale d'Oncologie Pediatrique (1) · University of South Florida (1)
United Kingdom (8) · France (6) · Germany (6) · United States (6) · Belgium (5) · Canada (5) · Denmark (5) · Netherlands (5) · Spain (5) · Switzerland (5) · Austria (4) · Slovakia (4) · Hungary (2) · Poland (2) · Puerto Rico (2)
A.N. Van Geel, MD (1) · Aaron R Weiss (1) · Andrea Ferrari, MD (1) · Bernadette Brennan, MD (1) · Ian R. Judson, MA, MD, FRCP (1) · James E. Butrynski, MD (1) · Jeffrey P. Krischer, PhD (1) · Joern Treuner, MD (1) · Laurence H. Baker, DO, FACOI (1) · M. C. G. Stevens, MD (1) · Martin Robinson, MD (1) · Max Van Noesel, MD, PhD (1) · Modesto Carli, MD (1) · Nguyen Binh Bui, MD (1)
PMID 17634494, PMID 20434400, PMID 22665534, PMID 22954508, PMID 24618336, PMID 24747207, PMID 28391003, PMID 29450452, PMID 30954717, PMID 31786124, PMID 32702309, PMID 32827353, PMID 33548339, PMID 34515544, PMID 34623899, PMID 34666214, PMID 36566574, PMID 37523624, PMID 38757485, PMID 39122389, PMID 41386267, PMID 42035475
U10CA098543 (2), 2009 (1), U10CA081920 (1), U10CA180830 (1), U10CA180886 (1)