51 completed, 23 unknown, 17 recruiting, 8 active not recruiting. 37 Not applicable, 28 Phase 2, 17 Phase 4, 12 Phase 1, 9 Phase 3.
Follow Combined Modality Therapy: new trials by email Literature Review of Combined Modality Therapy trials Research Report on Combined Modality Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Short Term Effects of a Multimodal Intervention With RGM on Cognition in People With Parkinson's Disease. Ronnie Gardiner Method - Parkinson Disease (PD), Cognition | Not applicable | Recruiting | University Ghent | 20 | 2026-08-01 | 2026-10-07 |
| Adebrelimab Plus Full-course Neoadjuvant Therapy for Resectable Locally Advanced ESCC (Phase 2) Combination therapy with chemotherapy and immunotherapy, Surgery - ESCC | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 200 | 2026-06-01 | 2026-05-13 |
| Real-world Study of SKB264 Monotherapy or Combination Therapy in Recurrent or Metastatic HER2-negative Breast Cancer SKB264 Monotherapy or Combination Therapy - HER2-negative Breast Cancer, Recurrence | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 500 | 2026-05-28 | 2026-08-18 | |
| Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre - Diabete Type 2 | Not applicable | Recruiting | Sharda University | 90 | 2026-05-01 | 2026-05-28 |
| A Study on the Pursuit of Sustained Clearance of HBsAg in Chronic Hepatitis B(CHB) Patients With Previous Interferon Treatment Using Pegylated Interferon Alpha PEG IFNα-2b monotherapy or combination therapy with NAs, NAs monotherapy group - Chronic Hepatitis b | Not yet recruiting | xieqing | 10000 | 2026-04-30 | 2026-04-17 | |
| Efficacy Comparison of DExamethasone Intravitreal Implant Combined With Aflibercept Versus Aflibercept Monotherapy in Treatment-naïve Inflammatory Diabetic Macular Edema Patients Combination Therapy with Aflibercept Intravitreous Injection (2mg) and Dexamethasone Intravitreal Implant, Aflibercept Intravitreous Injection (2mg) Monotherapy - Diabetic Macular Edema (DME) | Phase 4 | Not yet recruiting | Kun Liu | 114 | 2026-03-15 | 2026-02-27 |
| Neoadjuvant Becotatug Vedotin Plus Pucotenlimab and Cisplatin for Locally Advanced Head and Neck Squamous Cell Carcinoma Combination Therapy with Becotatug Vedotin, Pucotenlimab, and Cisplatin - Head and Neck Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma HNSCC | Phase 2 | Not yet recruiting | Sir Run Run Shaw Hospital | 30 | 2026-02-01 | 2026-02-06 |
| Golidocitinib Combined With Selinexor for CAEBVD golidocitinib, Selinexor (combination therapy) - Lymphohistiocytosis, EBV | Phase 2 / Phase 3 | Recruiting | Beijing Friendship Hospital | 28 | 2026-01-01 | 2026-01-27 |
| Comparison of Treatment Modalities in Myofascial Pain Syndrome Conventional treatment, Therapeutic Massage, combined treatment - Myofascial Pain Dysfunction Syndrome, Pain | Not applicable | Completed | Biruni University | 60 | 2025-12-29 | 2026-05-19 |
| Study on the Mechanism of ADC Drug Evaluation Based on Immune Co-culture of Lung Cancer Organoids Antibody-drug conjugate (ADC) combination therapy - HER2 Positive OR TROP2 Positive Non-Small Cell Lung Cancer | Recruiting | Guangzhou Institute of Respiratory Disease | 10 | 2025-12-28 | 2026-05-28 | |
| Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Combination therapy, Monotherapy - Combined Pre- and Post-capillary Pulmonary Hypertension, CpcPH | Phase 4 | Recruiting | Gachon University Gil Medical Center | 64 | 2025-11-24 | 2026-04-03 |
| A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma Combination therapy (COMB) - Esophageal Squamous Cell Carcinoma (ESCC) | Phase 2 | Active not recruiting | First Affiliated Hospital of Zhejiang University | 35 | 2025-08-06 | 2025-08-26 |
| Assessing the Safety and Efficacy of a Combination Therapy for STH in PSAC in Bangladesh A single dose of Albendazole 400mg + Ivermectin (200 µg/ kg) combination therapy, A single dose of 400 mg Oral Albendazole monotherapy - Soil Transmitted Helminth (STH) Infections | Phase 2 | Enrolling by invitation | International Centre for Diarrhoeal Disease Research, Bangladesh | 110 | 2025-07-10 | 2025-08-14 |
| Young Vulvodynia: Effect and Efficacy of Multimodal Treatment. Multimodal treatment - Vulvodynia | Not applicable | Active not recruiting | Region Örebro County | 15 | 2025-06-10 | 2026-08-12 |
| Immediate Fracture Risk After Antihypertensive Drug Initiation Monotherapy, Combination therapy - Hypertension, Fracture | Not yet recruiting | Ajou University School of Medicine | 10000000 | 2025-06-01 | 2025-05-28 | |
| Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus Combination therapy, High intensity statin monotherapy - ASCVD, Diabetes | Phase 4 | Recruiting | Korea University Anam Hospital | 2000 | 2025-04-25 | 2025-04-27 |
| Effects of Multimodal Therapy Versus Myofascial Release Techniques in Patient With Upper Cross Syndrome Myofascial Release Technique, Multimodal Therapy - Upper Extremity Dysfunction | Not applicable | Active not recruiting | Superior University | 36 | 2025-03-20 | 2025-05-20 |
| Antithrombotic Strategy for AF Patients With High Risk CAD Anticoagulation Monotherapy, Combination therapy - Atrial Fibrillation, Coronary Artery Disease | Not applicable | Not yet recruiting | Yonsei University | 1400 | 2025-03-01 | 2025-03-14 |
| A Preliminary Study on the Efficacy of Danggui Shaoyao San and Cuscuta Chinensis in Patients With Primary Dysmenorrhea Danggui Shaoyao San (DSS), Cuscuta Chinensis (Tu Si Zi), Combination Therapy (DSS + Tu Si Zi) - Primary Dysmenorrhea (PD), Traditional Chinese Medicine (TCM) Approaches | Not applicable | Terminated | Taichung Tzu Chi Hospital | 200 | 2025-02-14 | 2026-10-19 |
| A Study Comparing the Differences Between Young and Non-young Breast Cancer Age, combination therapy - Breast Cancer | Enrolling by invitation | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 3000 | 2025-01-01 | 2025-02-14 |
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Breast Neoplasms (6) · Hypertension (6) · Carcinoma, Non-Small-Cell Lung (4) · Coronary Artery Disease (3) · Dyslipidemias (3) · Essential Hypertension (3) · Hepatitis B, Chronic (3) · Neoplasm Metastasis (3) · Neoplasms (3) · Pain (3) · Pancreatic Neoplasms (3) · Recurrence (3) · Anxiety Disorders (2) · COVID-19 (2) · Depression (2)
Chong Kun Dang Pharmaceutical (3) · SCRI Development Innovations, LLC (3) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (2) · Gachon University Gil Medical Center (2) · GlaxoSmithKline (2) · National Taiwan University Hospital (2) · Riphah International University (2) · Shengjing Hospital (2) · The First Affiliated Hospital with Nanjing Medical University (2) · University of Valencia (2) · Zhejiang University (2) · ARCIM Institute Academic Research in Complementary and Integrative Medicine (1) · Aalborg University Hospital (1) · Air Force Military Medical University, China (1) · Ajou University School of Medicine (1)
China (23) · United States (21) · South Korea (10) · Spain (6) · Belgium (5) · Pakistan (5) · Germany (4) · Australia (3) · Canada (3) · Denmark (3) · Egypt (3) · France (3) · Turkey (Türkiye) (3) · India (2) · Italy (2)
Eunyoung Kim (2) · Abdullah T Aslan, Dr. (1) · Ahtsam Liaqat (1) · Amr Ahmed (1) · Andrea Tazbirkova, Dr (1) · Angela M Pinto, PhD (1) · Anjana N Bhat, PhD (1) · Bradley A Edwards, PhD (1) · Burcu Isler, MD (1) · Cai-Gang Liu, MD (1) · Cai-Gang Liu, PHD (1) · Chengzhi Zhou, PhD (1) · Daniel Strunk, PhD (1)
PMID 10333939, PMID 10368073, PMID 10561962, PMID 10565592, PMID 11270938, PMID 11673582, PMID 12087009, PMID 12186811, PMID 12403260, PMID 12474486, PMID 12592987, PMID 14734931, PMID 15159460, PMID 15509243, PMID 15541450, PMID 16713738, PMID 17426180, PMID 17559928, PMID 17601626, PMID 17919618, PMID 18077226, PMID 18331805, PMID 18414647, PMID 18781879, PMID 18974308, PMID 19265242, PMID 19407805, PMID 19589144, PMID 19762206, PMID 20167359, PMID 20471779, PMID 20608959, PMID 20888102, PMID 21070215, PMID 21216835, PMID 21617110, PMID 21693744, PMID 21884956, PMID 22021102, PMID 22366180, PMID 22410123, PMID 22416821, PMID 22689735, PMID 22859699, PMID 22892157, PMID 23404824, PMID 23675549, PMID 23704171, PMID 23842831, PMID 24239923
2017 (1), P20GM103446 (1), P30CA015083 (1), R01DK061486 (1), R01HL128658 (1)