61 completed, 25 recruiting, 18 terminated, 10 unknown. 66 Phase 2, 58 Phase 1, 15 Phase 3, 5 Not applicable, 2 Early Phase 1.
Follow Sarcoma, Synovial: new trials by email Literature Review of Sarcoma, Synovial trials Research Report on Sarcoma, Synovial
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C, Biopsy Procedure, Biospecimen Collection - Metastatic Myxoid Liposarcoma, Metastatic Synovial Sarcoma | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 42 | 2026-11-23 | 2026-09-25 |
| TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors TLN-499, Venetoclax - Small Cell Lung Cancer ( SCLC ), Neuroendocrine Cancer | Phase 1 | Recruiting | Treeline Biosciences, Inc. | 120 | 2026-08-05 | 2026-10-01 |
| A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies ZI-MA4-1 (TCR-NK cells), Cyclophosphamide, Fludarabine - Ovarian Cancer, Squamous Non-Small Cell Lung Cancer (NSCLC) | Phase 1 | Recruiting | Zelluna Immunotherapy AS | 9 | 2026-05-11 | 2026-09-04 |
| N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy Biospecimen Collection, Computed Tomography, Leukapheresis - Myxoid Liposarcoma, Round Cell Liposarcoma | Early Phase 1 | Recruiting | Seth Pollack | 8 | 2026-04-13 | 2026-08-27 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. Definitive radiotherapy - Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 40 | 2026-01-26 | 2026-01-28 |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma preoperative, Quality of life, Functional outcome - Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 110 | 2026-01-26 | 2026-01-28 |
| Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma TBI-1301, Cyclophosphamide, Fludarabine - Synovial Sarcomas | Phase 3 | Recruiting | Takara Bio Inc. | 5 | 2026-01-05 | 2026-09-28 |
| ACTengine® IMA203 Combined With mRNA-4203 IMA203, mRNA-4203 - Cutaneous Melanoma, Synovial Sarcoma | Phase 1 | Recruiting | Immatics US, Inc. | 15 | 2025-07-25 | 2026-01-08 |
| EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma Lymphodepletion, TCR-T cells (MDG1015) - Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer | Phase 1 | Not yet recruiting | Medigene AG | 55 | 2025-07-01 | 2024-12-27 |
| Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas CD146/HER2 CAR-T cells - Sarcoma, Sarcoma, Kaposi | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 60 | 2025-05-29 | 2025-07-15 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor Signifor - Desmoplastic Small Round Cell Tumor, Synovial Sarcoma | Phase 2 | Recruiting | University Hospital Heidelberg | 28 | 2024-12-19 | 2025-01-13 |
| First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors DS-2243a - Solid Tumors, Sarcoma | Phase 1 | Recruiting | Daiichi Sankyo | 150 | 2024-11-14 | 2026-09-04 |
| Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). Olaparib; 177Lu-DOTATATE - Solid Tumor Cancer, Medulloblastoma | Phase 1 / Phase 2 | Recruiting | Fundación de investigación HM | 25 | 2024-09-20 | 2026-06-04 |
| XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma Biospecimen Collection, Computed Tomography, Echocardiography - Metastatic Leiomyosarcoma, Unresectable Leiomyosarcoma | Phase 2 | Recruiting | Northwestern University | 73 | 2024-09-19 | 2026-10-13 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 Fludarabine phosphate, NY-ESO-1 TCR/IL-15 NK, Cyclophosphamide - Synovial Sarcoma, Myxoid/Round Cell Liposarcoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 44 | 2024-03-27 | 2026-07-29 |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma MASCT-I, Doxorubicin, Ifosfamide - Leiomyosarcoma, Liposarcoma | Phase 2 | Recruiting | HRYZ Biotech Co. | 148 | 2024-02-21 | 2025-07-24 |
| Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Dedifferentiated Liposarcoma, Metastatic Leiomyosarcoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 30 | 2024-02-06 | 2026-11-02 |
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Sarcoma (95) · Leiomyosarcoma (61) · Liposarcoma (52) · Histiocytoma, Malignant Fibrous (49) · Neurofibrosarcoma (47) · Fibrosarcoma (38) · Rhabdomyosarcoma (38) · Hemangiosarcoma (37) · Osteosarcoma (27) · Sarcoma, Alveolar Soft Part (23) · Liposarcoma, Myxoid (21) · Hemangiopericytoma, Malignant (19) · Sarcoma, Ewing (19) · Dermatofibrosarcoma (18)
Neoplasms by Histologic Type (133) · Neoplasms, Connective Tissue (133) · Neoplasms, Connective and Soft Tissue (132) · Neoplasms (125) · Neoplasms, Muscle Tissue (75) · Neoplasms, Adipose Tissue (67) · Neoplasms, Nerve Tissue (67) · Neoplasms, Fibrous Tissue (59) · Nervous System Diseases (52) · Nervous System Neoplasms (52) · Histiocytoma (49) · Neuromuscular Diseases (48) · Peripheral Nervous System Diseases (48) · Peripheral Nervous System Neoplasms (48) · Neurofibroma (47)
Doxorubicin (18) · Cyclophosphamide (16) · Ifosfamide (12) · fludarabine (9) · Radiotherapy (8) · pazopanib (5) · tazemetostat (5) · Gemcitabine (4) · Specimen Handling (4) · pembrolizumab (4) · Biopsy (3) · Dacarbazine (3) · Docetaxel (3) · Filgrastim (3) · Imatinib Mesylate (3)
European Organisation for Research and Treatment of Cancer - EORTC (14) · National Cancer Institute (NCI) (14) · Epizyme, Inc. (5) · USWM CT, LLC (5) · Fred Hutchinson Cancer Center (4) · M.D. Anderson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (3) · Brown University (2) · Children's Oncology Group (2) · Daiichi Sankyo (2) · Eli Lilly and Company (2) · GlaxoSmithKline (2) · Immune Design, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2) · Maria Sklodowska-Curie National Research Institute of Oncology (2) · OHSU Knight Cancer Institute (2)
United States (80) · France (20) · United Kingdom (19) · Germany (16) · Belgium (15) · Canada (15) · Netherlands (14) · Spain (14) · Italy (10) · Australia (9) · Denmark (8) · Poland (7) · China (5) · Japan (5) · Slovakia (5)
Seth Pollack (3) · Brian A Van Tine, M.D., Ph.D. (2) · Ivar Hompland, MD, PhD (2) · Kjetil Boye, MD, PhD (2) · Vivien H.C. Bramwell, MB, BS, PhD, FRCP (2) · A.N. Van Geel, MD (1) · Aaron H. Wolfson, MD (1) · Aaron R Weiss (1) · Alba Rubio (1) · Alexander Wei, MD (1) · Angela M. Corr, PT, DPT (1)
PMID 31401903, PMID 32002290, PMID 32269142, PMID 32827353, PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15659504, PMID 16528479, PMID 17095209, PMID 17109446, PMID 17336054, PMID 17634494, PMID 18286501, PMID 18448563, PMID 19088049, PMID 19451429, PMID 19451433, PMID 20434400, PMID 20471824, PMID 20932656, PMID 22682017, PMID 22954508, PMID 23382028, PMID 23554566, PMID 23640206, PMID 24215845, PMID 24504442, PMID 24618336, PMID 24747207, PMID 25258541, PMID 25858498, PMID 28391003, PMID 29149611, PMID 29450452, PMID 29884132, PMID 30410720, PMID 30954717, PMID 31215818, PMID 31786124, PMID 32029687, PMID 32702309, PMID 33035459, PMID 33203665, PMID 33548339, PMID 34260265, PMID 34515544
P30CA008748 (4), P30CA015704 (4), U10CA098543 (4), 2015 (3), K23CA175167 (2), N01CM62206 (2), P30CA060553 (2), U01CA069856 (2), U10CA180886 (2), UM1CA186709 (2), 2009 (1), 2018 (1), 2023 (1), K08CA245181 (1), K12CA076930 (1)