78 completed, 26 recruiting, 18 terminated, 15 unknown. 93 Phase 2, 40 Phase 1, 19 Phase 3, 7 Not applicable, 1 Early Phase 1.
Follow Leiomyosarcoma: new trials by email Literature Review of Leiomyosarcoma trials Research Report on Leiomyosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma Doxorubicin - Sarcoma | Phase 2 | Recruiting | University of Colorado, Denver | 20 | 2026-12-01 | 2026-02-05 |
| A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy REC617 - Phase 1b, Open Label | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 15 | 2026-10-19 | 2026-07-31 |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors Methionine-Reduced Diet - Adenocarcinoma, Basal Cell Carcinoma | Early Phase 1 | Recruiting | University of California, Irvine | 25 | 2026-05-01 | 2026-07-31 |
| A Study of Ivonescimab in People With Leiomyosarcoma Ivonescimab - Leiomyosarcoma | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 20 | 2026-04-01 | 2026-10-22 |
| Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma Abemaciclib, Biopsy Procedure, Biospecimen Collection - Advanced Dedifferentiated Liposarcoma, Advanced Leiomyosarcoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 74 | 2026-03-18 | 2026-10-21 |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. Definitive radiotherapy - Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 40 | 2026-01-26 | 2026-01-28 |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma preoperative, Quality of life, Functional outcome - Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 110 | 2026-01-26 | 2026-01-28 |
| Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma all-trans retinoic acid, Cemiplimab, Computed Tomography - Leiomyosarcoma, Sarcoma | Phase 2 | Recruiting | Gabriel Tinoco | 16 | 2025-09-10 | 2026-10-01 |
| STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas STC-15 in combination with toripalimab, STC-15 monotherapy - Solid Tumor, Sarcoma | Phase 1 / Phase 2 | Recruiting | STORM Therapeutics LTD | 107 | 2025-05-05 | 2026-10-22 |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors OKN4395, Pembrolizumab, Fasting - Solid Tumours, Sarcoma | Phase 1 | Recruiting | Epkin | 146 | 2025-01-23 | 2026-06-11 |
| The Role of Pre-Surgical Tru - Cut Biopsy in the Management of Atypical Myometrial Lesions tru cut biopsy - Leiomyosarcoma | Not yet recruiting | Charles University, Czech Republic | 250 | 2024-10-01 | 2024-07-25 | |
| XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma Biospecimen Collection, Computed Tomography, Echocardiography - Metastatic Leiomyosarcoma, Unresectable Leiomyosarcoma | Phase 2 | Recruiting | Northwestern University | 73 | 2024-09-19 | 2026-10-13 |
| A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions Gemcitabine, Nab-Sirolimus - Leiomyosarcoma, Soft-tissue Sarcomas | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 18 | 2024-08-14 | 2026-09-25 |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| Beliefs, Attitudes, and Response to Genetic Testing in SarcomaPatients Leiomyosarcoma | Recruiting | University of Utah | 300 | 2024-07-09 | 2025-06-13 | |
| NM32-2668 in Adult Patients With Selected Advanced Solid Tumors NM32-2668 - Ovarian Carcinoma, Fallopian Tube Carcinoma | Phase 1 | Terminated | Numab Therapeutics AG | 11 | 2024-05-01 | 2025-07-23 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma MASCT-I, Doxorubicin, Ifosfamide - Leiomyosarcoma, Liposarcoma | Phase 2 | Recruiting | HRYZ Biotech Co. | 148 | 2024-02-21 | 2025-07-24 |
Showing 20 of 157. Sign in to see all of them.
Sarcoma (99) · Liposarcoma (81) · Histiocytoma, Malignant Fibrous (61) · Sarcoma, Synovial (61) · Hemangiosarcoma (46) · Neurofibrosarcoma (46) · Fibrosarcoma (45) · Rhabdomyosarcoma (27) · Dermatofibrosarcoma (22) · Sarcoma, Alveolar Soft Part (22) · Hemangiopericytoma, Malignant (20) · Osteosarcoma (20) · Malignant mesenchymal tumor (18) · Ovarian Neoplasms (15)
Neoplasms by Histologic Type (157) · Neoplasms, Muscle Tissue (157) · Neoplasms, Connective and Soft Tissue (156) · Neoplasms (153) · Neoplasms, Connective Tissue (89) · Neoplasms, Adipose Tissue (81) · Neoplasms, Fibrous Tissue (73) · Histiocytoma (60) · Sarcoma (58) · Neoplasms, Nerve Tissue (53) · Nervous System Diseases (49) · Nervous System Neoplasms (49) · Neoplasms, Vascular Tissue (47) · Neuromuscular Diseases (47) · Peripheral Nervous System Diseases (47)
Doxorubicin (26) · Gemcitabine (16) · Ifosfamide (13) · Trabectedin (12) · Radiotherapy (11) · Docetaxel (10) · Dacarbazine (8) · pazopanib (8) · Nivolumab (6) · Biopsy (5) · Specimen Handling (5) · Temozolomide (4) · liposomal doxorubicin (4) · pembrolizumab (4) · Filgrastim (3)
European Organisation for Research and Treatment of Cancer - EORTC (15) · National Cancer Institute (NCI) (13) · Memorial Sloan Kettering Cancer Center (10) · M.D. Anderson Cancer Center (5) · Dana-Farber Cancer Institute (3) · Eli Lilly and Company (3) · Baylor College of Medicine (2) · Brown University (2) · City of Hope Medical Center (2) · Fred Hutchinson Cancer Center (2) · Grupo Espanol de Investigacion en Sarcomas (2) · Herbert Irving Comprehensive Cancer Center (2) · Igenomix (2) · Institut Bergonié (2) · Institut Claudius Regaud (2)
United States (95) · France (23) · United Kingdom (21) · Germany (19) · Spain (18) · Canada (16) · Belgium (15) · Netherlands (14) · Italy (13) · Denmark (11) · Australia (10) · Poland (10) · Austria (7) · Slovakia (6) · Brazil (5)
William Tap, MD (3) · Aymara Mas, PhD (2) · Elise Nassif, MD (2) · Ivar Hompland, MD, PhD (2) · Kjetil Boye, MD, PhD (2) · Margaret von Mehren, MD (2) · Robert Maki, MD, PhD (2) · Robert N. Taub, MD, PhD (2) · Sandra D'Angelo, MD (2) · Scott Schuetze (2) · Suzanne George, MD (2) · A.N. Van Geel, MD (1) · Aaron H. Wolfson, MD (1)
PMID 31401903, PMID 32827353, PMID 30262660, PMID 11705489, PMID 12065559, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15659504, PMID 16528479, PMID 17095209, PMID 17109446, PMID 17336054, PMID 17609424, PMID 17634494, PMID 19043564, PMID 19088049, PMID 19451429, PMID 19451433, PMID 20434400, PMID 20471824, PMID 20671118, PMID 20932656, PMID 21454450, PMID 22067397, PMID 22682017, PMID 22954508, PMID 23335221, PMID 23382028, PMID 23640206, PMID 24215845, PMID 24344220, PMID 24504442, PMID 24618336, PMID 24747207, PMID 25258541, PMID 25591040, PMID 25858498, PMID 26371143, PMID 27502708, PMID 28391003, PMID 28447475, PMID 28662235, PMID 29177975, PMID 29450452, PMID 30084934, PMID 30410720, PMID 30954717
P30CA008748 (4), P50CA272170 (3), UM1CA186709 (3), 2009 (2), N01CM62206 (2), P30CA060553 (2), U10CA032102 (2), U10CA098543 (2), U10CA180821 (2), 2004 (1), 2014 (1), 2015 (1), 2018 (1), K08CA245181 (1), N01CM00071 (1)