82 completed, 33 recruiting, 20 terminated, 17 unknown. 103 Phase 2, 61 Phase 1, 22 Phase 3, 7 Not applicable, 3 Early Phase 1.
Follow Liposarcoma: new trials by email Literature Review of Liposarcoma trials Research Report on Liposarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma DT-7012, Doxorubicin - Undifferentiated Pleomorphic Sarcoma (UPS), Dedifferentiated Liposarcoma (DDLPS) | Phase 2 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 80 | 2027-02-01 | 2026-09-15 |
| Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C, Biopsy Procedure, Biospecimen Collection - Metastatic Myxoid Liposarcoma, Metastatic Synovial Sarcoma | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 42 | 2026-11-23 | 2026-09-25 |
| A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma Lifileucel - Sarcoma, Soft Tissue Sarcoma (STS) | Phase 2 | Recruiting | Iovance Biotherapeutics, Inc. | 80 | 2026-10-02 | 2026-10-09 |
| N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy Biospecimen Collection, Computed Tomography, Leukapheresis - Myxoid Liposarcoma, Round Cell Liposarcoma | Early Phase 1 | Recruiting | Seth Pollack | 8 | 2026-04-13 | 2026-08-27 |
| Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Hepatocellular Carcinoma | Phase 1 | Not yet recruiting | Seattle Children's Hospital | 21 | 2026-04-01 | 2025-11-04 |
| Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma Abemaciclib, Biopsy Procedure, Biospecimen Collection - Advanced Dedifferentiated Liposarcoma, Advanced Leiomyosarcoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 74 | 2026-03-18 | 2026-10-21 |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. Definitive radiotherapy - Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 40 | 2026-01-26 | 2026-01-28 |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma preoperative, Quality of life, Functional outcome - Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 110 | 2026-01-26 | 2026-01-28 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| A Study of Pembrolizumab in People With Ultra-Rare Sarcomas Pembrolizumab - Sarcoma | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 32 | 2025-12-04 | 2026-07-28 |
| EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma Lymphodepletion, TCR-T cells (MDG1015) - Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer | Phase 1 | Not yet recruiting | Medigene AG | 55 | 2025-07-01 | 2024-12-27 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas STC-15 in combination with toripalimab, STC-15 monotherapy - Solid Tumor, Sarcoma | Phase 1 / Phase 2 | Recruiting | STORM Therapeutics LTD | 107 | 2025-05-05 | 2026-10-22 |
| A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism Ersodetug - Tumor Hyperinsulinism (Tumor HI) | Phase 3 | Recruiting | Rezolute | 16 | 2025-04-16 | 2026-09-28 |
| A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas Abemaciclib, Computed Tomography, Magnetic Resonance Imaging - Retroperitoneal Sarcoma, Liposarcoma | Phase 1 | Recruiting | University of Washington | 18 | 2025-03-19 | 2026-09-17 |
| Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors SA53-OS (phase 1), SA53-OS (phase 2) - Solid Tumor | Phase 1 / Phase 2 | Recruiting | Lamassu Bio Inc | 70 | 2025-03-10 | 2026-09-09 |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma Mirdametinib, Palbociclib - Well Differentiated Liposarcoma, Dedifferentiated Liposarcoma | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 54 | 2025-02-19 | 2026-09-16 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors OKN4395, Pembrolizumab, Fasting - Solid Tumours, Sarcoma | Phase 1 | Recruiting | Epkin | 146 | 2025-01-23 | 2026-06-11 |
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Sarcoma (115) · Leiomyosarcoma (82) · Sarcoma, Synovial (68) · Histiocytoma, Malignant Fibrous (56) · Fibrosarcoma (52) · Hemangiosarcoma (49) · Liposarcoma, Myxoid (40) · Neurofibrosarcoma (40) · Rhabdomyosarcoma (34) · Dermatofibrosarcoma (23) · Hemangiopericytoma, Malignant (22) · Malignant mesenchymal tumor (21) · Osteosarcoma (20) · Sarcoma, Alveolar Soft Part (20)
Neoplasms by Histologic Type (187) · Neoplasms, Adipose Tissue (186) · Neoplasms, Connective and Soft Tissue (186) · Neoplasms (172) · Neoplasms, Connective Tissue (106) · Neoplasms, Muscle Tissue (93) · Neoplasms, Fibrous Tissue (75) · Sarcoma (72) · Neoplasms, Nerve Tissue (58) · Histiocytoma (56) · Neoplasms, Vascular Tissue (50) · Nervous System Diseases (43) · Nervous System Neoplasms (43) · Neoplasms by Site (41) · Peripheral Nervous System Neoplasms (41)
Doxorubicin (26) · Cyclophosphamide (16) · Radiotherapy (16) · Ifosfamide (14) · Trabectedin (11) · Biopsy (7) · Magnetic Resonance Spectroscopy (7) · Specimen Handling (7) · fludarabine (7) · pembrolizumab (7) · pazopanib (6) · Gemcitabine (5) · Radiation (5) · ribociclib (5) · Chemotherapy, Adjuvant (4)
National Cancer Institute (NCI) (16) · European Organisation for Research and Treatment of Cancer - EORTC (15) · Memorial Sloan Kettering Cancer Center (9) · Fred Hutchinson Cancer Center (6) · M.D. Anderson Cancer Center (5) · Baylor College of Medicine (4) · Dana-Farber Cancer Institute (4) · USWM CT, LLC (4) · Adaptimmune (3) · Alliance for Clinical Trials in Oncology (3) · Boehringer Ingelheim (3) · Children's Oncology Group (3) · Maria Sklodowska-Curie National Research Institute of Oncology (3) · OHSU Knight Cancer Institute (3) · Pfizer (3)
United States (123) · France (30) · United Kingdom (28) · Canada (27) · Germany (22) · Netherlands (20) · Spain (18) · Belgium (17) · Italy (14) · Denmark (13) · Australia (11) · Sweden (10) · China (9) · Poland (9) · Norway (6)
Seth Pollack (5) · Adaptimmune Patient Enquiries (3) · David Steffin, MD (3) · George D. Demetri, MD (3) · Sandra D'Angelo, MD (3) · Benjamin Izar, MD (2) · Ivar Hompland, MD, PhD (2) · Kjetil Boye, MD, PhD (2) · Lara E Davis (2) · Margaret von Mehren, MD (2) · Mark Dickson, MD (2) · Neeta Somaiah (2) · Robert Maki, MD, PhD (2)
PMID 32827353, PMID 31401903, PMID 19451433, PMID 32002290, PMID 32269142, PMID 10097144, PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15659504, PMID 16528479, PMID 17095209, PMID 17109446, PMID 17336054, PMID 17634494, PMID 19088049, PMID 19451429, PMID 20338746, PMID 20434400, PMID 20471824, PMID 20932656, PMID 21642514, PMID 22067397, PMID 22665534, PMID 22954508, PMID 23382028, PMID 23569312, PMID 23640206, PMID 24215845, PMID 24618336, PMID 24747207, PMID 25258541, PMID 25591040, PMID 25858498, PMID 26041763, PMID 27124835, PMID 27502708, PMID 28391003, PMID 28447475, PMID 29149611, PMID 29370992, PMID 29450452, PMID 30249211, PMID 30410720, PMID 30954717, PMID 31012962, PMID 31013172
P30CA015704 (6), P30CA006516 (3), U10CA098543 (3), UM1CA186709 (3), 2015 (2), 2019 (2), K23CA175167 (2), P30CA008748 (2), P30CA016672 (2), P30CA060553 (2), U10CA180821 (2), 2004 (1), 2023 (1), K12CA076930 (1), N01CM00071 (1)