74 completed, 24 recruiting, 15 terminated, 11 unknown. 86 Phase 2, 46 Phase 1, 16 Phase 3, 7 Not applicable, 1 Early Phase 1.
Follow Fibrosarcoma: new trials by email Literature Review of Fibrosarcoma trials Research Report on Fibrosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas Selumetinib + ZEN-3694 ± Durvalumab - MPNST, NF1 | Phase 2 | Recruiting | University of Alabama at Birmingham | 41 | 2026-08-04 | 2026-08-24 |
| Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor BMS-986504 - Malignant Peripheral Nerve Sheath Tumors, MPNST | Phase 1 / Phase 2 | Recruiting | Ankit Mangla, MD | 17 | 2026-08-01 | 2026-08-11 |
| Exploratory Study on Toripalimab and Anlotinib Combined With Standard Chemotherapy for Refractory Dermatofibrosarcoma Protuberans Toripalimab, Anlotinib, Standard Chemotherapy - Dermatofibrosarcoma Protuberans (DFSP) | Phase 2 | Not yet recruiting | Yanjie Zhang, MD | 20 | 2026-06-15 | 2026-06-16 |
| Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST APG-115, Selumetinib - Malignant Peripheral Nerve Sheath Tumor (MPNST), Neurofibromatosis 1 (NF1) | Phase 1 / Phase 2 | Recruiting | AeRang Kim | 45 | 2026-06-01 | 2026-07-27 |
| DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins Neurofibromas, MPNST | Recruiting | M.D. Anderson Cancer Center | 60 | 2026-04-02 | 2026-09-18 | |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. Definitive radiotherapy - Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 40 | 2026-01-26 | 2026-01-28 |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma preoperative, Quality of life, Functional outcome - Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 110 | 2026-01-26 | 2026-01-28 |
| A Study of DEG6498 in Participants With Solid Tumors DEG6498 - Malignant Neoplasms | Phase 1 | Recruiting | Degron Therapeutics Co. | 100 | 2025-11-13 | 2026-06-30 |
| A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism Ersodetug - Tumor Hyperinsulinism (Tumor HI) | Phase 3 | Recruiting | Rezolute | 16 | 2025-04-16 | 2026-09-28 |
| Using CICS-1 and SPM-011 and ［18F］FBPA Commissioned by CICS and Sumitomo Heavy Industries and STELLA PHARMA BNCT, ［18F］FBPA - Thoracic Solid Malignant Tumor | Phase 1 / Phase 2 | Enrolling by invitation | Stella Pharma Corporation | 30 | 2025-04-10 | 2025-11-19 |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors OKN4395, Pembrolizumab, Fasting - Solid Tumours, Sarcoma | Phase 1 | Recruiting | Epkin | 146 | 2025-01-23 | 2026-06-11 |
| NIFR Image-guided Surgery for Malignant Soft Tissue Tumor With Low-dose SWIG Technique ICG administration - Dermatofibrosarcoma Protuberans (DFSP), Skin Squamous Cell Carcinoma | Phase 1 | Not yet recruiting | The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College | 592 | 2024-10-30 | 2024-09-24 |
| Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST) Neurofibromatosis 1, Nerve Sheath Neoplasms | Recruiting | National Cancer Institute (NCI) | 225 | 2024-10-09 | 2026-09-02 | |
| Neurofibromatosis Type 1 Tumor Early Detection Study Liquid biopsy for MPNST development - Neurofibromatosis Type 1, Neurofibromatosis 1 | Enrolling by invitation | David Miller | 1000 | 2024-08-07 | 2026-08-31 | |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma Brigimadlin, Ezabenlimab, Gemcitabine - Advanced Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma (UPS) | Phase 3 | Withdrawn | Boehringer Ingelheim | 2024-06-27 | 2024-07-17 | |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
Showing 20 of 148. Sign in to see all of them.
Neurofibrosarcoma (97) · Sarcoma (97) · Liposarcoma (65) · Leiomyosarcoma (63) · Histiocytoma, Malignant Fibrous (60) · Sarcoma, Synovial (55) · Hemangiosarcoma (50) · Dermatofibrosarcoma (41) · Rhabdomyosarcoma (37) · Osteosarcoma (25) · Sarcoma, Alveolar Soft Part (24) · Hemangiopericytoma, Malignant (23) · Malignant mesenchymal tumor (23) · Chondrosarcoma (17)
Neoplasms by Histologic Type (148) · Neoplasms, Connective Tissue (148) · Neoplasms, Fibrous Tissue (148) · Neoplasms, Connective and Soft Tissue (147) · Neoplasms (139) · Neoplasms, Nerve Tissue (112) · Nervous System Diseases (100) · Nervous System Neoplasms (100) · Neuromuscular Diseases (97) · Peripheral Nervous System Diseases (97) · Peripheral Nervous System Neoplasms (97) · Neurofibroma (92) · Nerve Sheath Neoplasms (91) · Neoplasms, Muscle Tissue (77)
Doxorubicin (21) · Ifosfamide (17) · Radiotherapy (12) · Imatinib Mesylate (10) · Filgrastim (7) · Etoposide (6) · pazopanib (6) · pembrolizumab (6) · Cyclophosphamide (5) · Chemotherapy, Adjuvant (4) · Dactinomycin (4) · Docetaxel (4) · Gemcitabine (4) · Magnetic Resonance Spectroscopy (4) · Sirolimus (4)
National Cancer Institute (NCI) (18) · European Organisation for Research and Treatment of Cancer - EORTC (15) · Memorial Sloan Kettering Cancer Center (8) · Children's Oncology Group (6) · Sarcoma Alliance for Research through Collaboration (6) · Novartis Pharmaceuticals (3) · Oslo University Hospital (3) · Brown University (2) · KU Leuven (2) · M.D. Anderson Cancer Center (2) · Maria Sklodowska-Curie National Research Institute of Oncology (2) · Mayo Clinic (2) · OHSU Knight Cancer Institute (2) · Rezolute (2) · SWOG Cancer Research Network (2)
United States (97) · United Kingdom (19) · France (16) · Belgium (14) · Canada (14) · Germany (11) · Denmark (10) · Netherlands (10) · Spain (9) · Australia (7) · Switzerland (6) · Poland (5) · Slovakia (5) · Austria (4) · China (4)
AeRang Kim, MD, PhD (3) · Brigitte C Widemann, M.D. (3) · Brigitte C. Widemann, MD (2) · Brigitte Widemann, MD (2) · Eric Legius, MD PhD (2) · Ivar Hompland, MD, PhD (2) · Kjetil Boye, MD, PhD (2) · Scott Schuetze, MD, PhD (2) · William Tap, MD (2) · A.N. Van Geel, MD (1) · Aaron H. Wolfson, MD (1) · Aaron R Weiss (1) · Alberto Chiappori, M.D. (1) · Albiruni Razak, M.D. (1)
PMID 31401903, PMID 19451433, PMID 32827353, PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15659504, PMID 16528479, PMID 17095209, PMID 17109446, PMID 17336054, PMID 17634494, PMID 19088049, PMID 19451429, PMID 20338746, PMID 20434400, PMID 20471824, PMID 20932656, PMID 22665534, PMID 22954508, PMID 23382028, PMID 23640206, PMID 24215845, PMID 24321536, PMID 24618336, PMID 24747207, PMID 25858498, PMID 27502708, PMID 28391003, PMID 29450452, PMID 30410720, PMID 30954717, PMID 31786124, PMID 31969335, PMID 32089640, PMID 32152628, PMID 32554315, PMID 32702309, PMID 32941794, PMID 32956651, PMID 33362722, PMID 33548339, PMID 33641042, PMID 33882143, PMID 34321280, PMID 34380663, PMID 34515544
P30CA008748 (3), U10CA032102 (3), U10CA098543 (3), 2009 (2), N01CM62206 (2), U10CA180821 (2), U10CA180886 (2), 2008 (1), K08CA245181 (1), N01CM00071 (1), N01CM62201 (1), N01CM62203 (1), P30CA012197 (1), P30CA014599 (1), P30CA016087 (1)