44 completed, 17 recruiting, 10 terminated, 9 active not recruiting. 57 Phase 2, 35 Phase 1, 11 Phase 3, 3 Not applicable.
Follow Neurofibrosarcoma: new trials by email Literature Review of Neurofibrosarcoma trials Research Report on Neurofibrosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas Selumetinib + ZEN-3694 ± Durvalumab - MPNST, NF1 | Phase 2 | Recruiting | University of Alabama at Birmingham | 41 | 2026-08-04 | 2026-08-24 |
| Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor BMS-986504 - Malignant Peripheral Nerve Sheath Tumors, MPNST | Phase 1 / Phase 2 | Recruiting | Ankit Mangla, MD | 17 | 2026-08-01 | 2026-08-11 |
| Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST APG-115, Selumetinib - Malignant Peripheral Nerve Sheath Tumor (MPNST), Neurofibromatosis 1 (NF1) | Phase 1 / Phase 2 | Recruiting | AeRang Kim | 45 | 2026-06-01 | 2026-07-27 |
| DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins Neurofibromas, MPNST | Recruiting | M.D. Anderson Cancer Center | 60 | 2026-04-02 | 2026-09-18 | |
| A Study of DEG6498 in Participants With Solid Tumors DEG6498 - Malignant Neoplasms | Phase 1 | Recruiting | Degron Therapeutics Co. | 100 | 2025-11-13 | 2026-06-30 |
| Using CICS-1 and SPM-011 and ［18F］FBPA Commissioned by CICS and Sumitomo Heavy Industries and STELLA PHARMA BNCT, ［18F］FBPA - Thoracic Solid Malignant Tumor | Phase 1 / Phase 2 | Enrolling by invitation | Stella Pharma Corporation | 30 | 2025-04-10 | 2025-11-19 |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST) Neurofibromatosis 1, Nerve Sheath Neoplasms | Recruiting | National Cancer Institute (NCI) | 225 | 2024-10-09 | 2026-11-03 | |
| Neurofibromatosis Type 1 Tumor Early Detection Study Liquid biopsy for MPNST development - Neurofibromatosis Type 1, Neurofibromatosis 1 | Enrolling by invitation | David Miller | 1000 | 2024-08-07 | 2026-08-31 | |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma MASCT-I, Doxorubicin, Ifosfamide - Leiomyosarcoma, Liposarcoma | Phase 2 | Recruiting | HRYZ Biotech Co. | 148 | 2024-02-21 | 2025-07-24 |
| SPEARHEAD-3 Pediatric Study Afamitresgene autoleucel - Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST) | Phase 1 / Phase 2 | Recruiting | USWM CT, LLC | 20 | 2023-09-01 | 2026-08-11 |
| A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors Selinexor - Wilms Tumor, Rhabdoid Tumor | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2023-08-01 | 2026-10-23 |
| Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors TNG462, Pembrolizumab - Locally Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Tango Therapeutics, Inc. | 225 | 2023-05-26 | 2026-09-08 |
| B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) Fludarabine, Cyclophosphamide, MESNA - Pediatric Solid Tumor, Osteosarcoma | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 48 | 2022-07-06 | 2026-05-19 |
| Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion MRTX1719 - Mesothelioma, Non Small Cell Lung Cancer | Phase 1 | Recruiting | Bristol-Myers Squibb | 336 | 2022-06-09 | 2026-09-02 |
| Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors TNG908 - Locally Advanced Solid Tumor | Phase 1 / Phase 2 | Terminated | Tango Therapeutics, Inc. | 110 | 2022-03-23 | 2026-04-15 |
Showing 20 of 97. Sign in to see all of them.
Sarcoma (63) · Sarcoma, Synovial (47) · Leiomyosarcoma (46) · Histiocytoma, Malignant Fibrous (41) · Liposarcoma (40) · Fibrosarcoma (38) · Hemangiosarcoma (35) · Rhabdomyosarcoma (30) · Sarcoma, Alveolar Soft Part (23) · Hemangiopericytoma, Malignant (19) · Malignant mesenchymal tumor (18) · Dermatofibrosarcoma (15) · Chondrosarcoma, Extraskeletal Myxoid (14) · Neurofibromatosis 1 (13)
Neoplasms by Histologic Type (97) · Neoplasms, Connective Tissue (97) · Neoplasms, Fibrous Tissue (97) · Neoplasms, Nerve Tissue (97) · Nervous System Diseases (97) · Nervous System Neoplasms (97) · Neuromuscular Diseases (97) · Peripheral Nervous System Diseases (97) · Neoplasms, Connective and Soft Tissue (96) · Peripheral Nervous System Neoplasms (96) · Neoplasms (95) · Neurofibroma (92) · Nerve Sheath Neoplasms (91) · Fibrosarcoma (59) · Neoplasms, Muscle Tissue (57)
Doxorubicin (17) · Ifosfamide (12) · Radiotherapy (8) · pazopanib (5) · Filgrastim (4) · pembrolizumab (4) · selinexor (4) · AZD 6244 (3) · Etoposide (3) · Imatinib Mesylate (3) · Magnetic Resonance Spectroscopy (3) · Nivolumab (3) · Sirolimus (3) · pegfilgrastim (3) · Biopsy (2)
European Organisation for Research and Treatment of Cancer - EORTC (13) · National Cancer Institute (NCI) (13) · Memorial Sloan Kettering Cancer Center (5) · Sarcoma Alliance for Research through Collaboration (5) · Children's Oncology Group (2) · KU Leuven (2) · M.D. Anderson Cancer Center (2) · Maria Sklodowska-Curie National Research Institute of Oncology (2) · Novartis Pharmaceuticals (2) · OHSU Knight Cancer Institute (2) · Seattle Children's Hospital (2) · St. Jude Children's Research Hospital (2) · Tango Therapeutics, Inc. (2) · University of Florida (2) · Washington University School of Medicine (2)
United States (62) · Belgium (11) · Germany (9) · United Kingdom (9) · Canada (8) · France (8) · Denmark (7) · Netherlands (7) · Slovakia (5) · Spain (5) · China (4) · Poland (4) · Austria (3) · Switzerland (3) · Australia (2)
AeRang Kim, MD, PhD (3) · Brigitte C Widemann, M.D. (3) · Brigitte C. Widemann, MD (2) · Brigitte Widemann, MD (2) · Eric Legius, MD PhD (2) · William Tap, MD (2) · A.N. Van Geel, MD (1) · Aaron H. Wolfson, MD (1) · Aaron R Weiss (1) · Albiruni Razak, M.D. (1) · Alexander Wei, MD (1) · Angela Hirbe, M.D., Ph.D. (1) · Ankit Mangla, MD (1) · Axel Le Cesne, MD (1) · Brian A Van Tine, M.D., Ph.D. (1)
PMID 31401903, PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15659504, PMID 16528479, PMID 17095209, PMID 17336054, PMID 17634494, PMID 19088049, PMID 19451429, PMID 19451433, PMID 20434400, PMID 20471824, PMID 22954508, PMID 23382028, PMID 23640206, PMID 24215845, PMID 24321536, PMID 24618336, PMID 24747207, PMID 25858498, PMID 27502708, PMID 28391003, PMID 29450452, PMID 30410720, PMID 30954717, PMID 31786124, PMID 31969335, PMID 32089640, PMID 32152628, PMID 32702309, PMID 32827353, PMID 33362722, PMID 33548339, PMID 33641042, PMID 33882143, PMID 34321280, PMID 34380663, PMID 34515544, PMID 34623899, PMID 34666214, PMID 34716198, PMID 35007270, PMID 36566574, PMID 37523624, PMID 38243705
P30CA008748 (3), N01CM62206 (2), U10CA098543 (2), U10CA180821 (2), U10CA180886 (2), 2009 (1), K08CA245181 (1), N01CM00071 (1), N01CM62201 (1), P30CA012197 (1), P30CA014599 (1), P30CA033572 (1), U01CA069856 (1), U10CA031946 (1), U10CA032102 (1)