8 completed, 3 unknown, 2 recruiting, 1 active not recruiting. 15 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 8, Unknown 3, Recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 1 | 5 | Completed 4, Active not recruiting 1 |
| Phase 3 | 2 | Unknown 2 |
Follow Dystonic Disorders: new trials by email Literature Review of Dystonic Disorders trials Research Report on Dystonic Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia VIM0423, VIM0423 Placebo - Dystonia | Phase 2 | Recruiting | Vima Therapeutics | 100 | 2026-02-05 | 2026-10-26 |
| An Open-label Study to Define the Safety, Tolerability and Clinical Activity of Deutetrabenazine (AUstedo) in Adult Study Subjects With DYsTonia Deutetrabenazine 6 MG - Dystonia, Primary | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 15 | 2021-04-29 | 2024-09-20 |
| Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease Botulinum toxin type A, Placebo - Dystonia Disorder, Parkinson Disease | Phase 2 / Phase 3 | Unknown | University of Calgary | 40 | 2021-01-12 | 2022-05-17 |
| Video-supervised Motor and Awareness Training in Writer's Cramp motor training, mindfulness exercises - Writer's Cramp | Phase 2 | Recruiting | University Hospital Schleswig-Holstein | 54 | 2020-06-26 | 2024-12-10 |
| Deep Brain Stimulation Surgery for Focal Hand Dystonia DBS surgery, Medtronic Activa Rechargeable System - Dystonia, Focal Dystonia | Phase 1 / Phase 2 | Active not recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 5 | 2018-01-17 | 2026-10-29 |
| Wumeiwan Jiawei Fang Use in Patients With Blepharospasm Wumeiwan Jiawei Fang, botulinum toxin A - Dry Eye Syndromes, Meige Syndrome | Phase 2 / Phase 3 | Unknown | China Academy of Chinese Medical Sciences | 80 | 2018-01-12 | 2022-11-17 |
| Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp BoNT Injections, Occupational Therapy - Dystonia | Phase 1 / Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 13 | 2013-12-03 | 2018-03-20 |
| Acetyl Hexapeptide-8 for Blepharospasm Topical acetyl hexapeptide-8, Placebo - Focal Dystonia | Phase 2 | Terminated | National Institute of Neurological Disorders and Stroke (NINDS) | 8 | 2012-11-01 | 2016-11-10 |
| rTMS and Retraining in Focal Hand Dystonia Repetitive Transcranial Magnetic Stimulation, Sensorimotor Retraining, Non-specific Therapy - Focal Dystonia | Phase 1 / Phase 2 | Completed | University of Minnesota | 9 | 2011-11-01 | 2019-11-18 |
| Transcranial Direct-Current Stimulation in Childhood Dystonia TDCS (Transcranial Direct-current Stimulation), sham TDCS (Transcranial Direct-current Stimulation) - Childhood Onset Dystonias | Phase 2 | Unknown | University of Southern California | 100 | 2011-09-01 | 2014-05-22 |
| A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm Acetyl-Hexapeptide Topical Treatment, placebo - Focal Dystonia | Phase 1 / Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 2009-07-01 | 2012-09-06 |
| Brain Stimulation to Treat Blepharospasm or Meige Syndrome repetitive transcranial magnetic stimulation (rTMS) - Blepharospasm, Focal Dystonia | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 22 | 2006-06-22 | 2017-07-02 |
| Motor Training to Treat Hand Dystonia constraint-induced movement therapy - Focal Dystonia | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 15 | 2001-08-01 | 2008-03-04 |
| Amlodipine Plus Botulinum Toxin for Focal Dystonia Amlodipine plus Botulinum toxin - Focal Dystonia | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 16 | 2001-04-01 | 2013-04-01 |
| Mexiletine for the Treatment of Focal Dystonia Mexiletine - Blepharospasm, Dystonia | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 1998-07-01 | 2008-03-04 |
Dystonia (9) · Blepharospasm (5) · Dystonia, Focal, Task-Specific (3) · Spasm (2) · Torticollis (2) · Dry Eye Syndromes (1) · Meige Syndrome (1) · Movement Disorders (1) · Parkinson Disease (1)
Central Nervous System Diseases (15) · Nervous System Diseases (15) · Movement Disorders (14) · Neurologic Manifestations (11) · Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (11) · Dyskinesias (10) · Eye Diseases (5) · Eyelid Diseases (5) · Basal Ganglia Diseases (2) · Brain Diseases (2) · Neuromuscular Manifestations (2) · Dystonia (1) · Lacrimal Apparatus Diseases (1)
Botulinum Toxins, Type A (2) · Transcranial Magnetic Stimulation (2) · Amlodipine (1) · Botulinum Toxins (1) · Constraint Induced Movement Therapy (1) · Massage (1) · Mexiletine (1) · Occupational Therapy (1) · Sodium Chloride (1) · Transcranial Direct Current Stimulation (1) · Transcutaneous Electric Nerve Stimulation (1) · acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide (1) · deutetrabenazine (1)
National Institute of Neurological Disorders and Stroke (NINDS) (8) · China Academy of Chinese Medical Sciences (1) · University Hospital Schleswig-Holstein (1) · University of Calgary (1) · University of Minnesota (1) · University of Pennsylvania (1) · University of Southern California (1) · Vima Therapeutics (1)
United States (12) · Canada (2) · China (1) · Germany (1)
Codrin I Lungu, M.D. (1) · Debra J Ehrlich, M.D. (1) · Kirsten E Zeuner, Prof. MD (1) · Mark Hallett, M.D. (1) · Terence Sanger, MD, PhD (1) · Teresa J Kimberley, PhD, PT (1) · Veronica Bruno, MD, MPH (1)