5 completed, 3 not yet recruiting, 2 enrolling by invitation, 1 unknown. 11 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Completed 5, Not yet recruiting 3, Enrolling by invitation 2, Unknown 1 |
Follow Dysbiosis: new trials by email Literature Review of Dysbiosis trials Research Report on Dysbiosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV Vaginal estradiol tablets, Vaginal moisturizer - Menopausal Complaints, Vaginal Atrophy | Phase 4 | Not yet recruiting | Albert Einstein College of Medicine | 62 | 2026-09-01 | 2026-07-28 |
| Modulation of Gut MicroFLORA With Rifaximin to Reduce High Platelet Reactivity in Post-ACS Patients on Ticagrelor Rifaximin - ACS - Acute Coronary Syndrome, Ticagrelor | Phase 4 | Not yet recruiting | Collegium Medicum w Bydgoszczy | 50 | 2026-01-01 | 2025-10-02 |
| Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee Probiotic, Standard of care - Prosthetic-joint Infection, Dysbiosis | Phase 4 | Enrolling by invitation | Boston Medical Center | 152 | 2025-08-15 | 2026-08-26 |
| Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery Placebo Capsule, Probiotic with Human Milk Oligosaccharides (HMO) - Dysbiosis, Gut -microbiota | Phase 4 | Not yet recruiting | Acibadem Maslak Hospital | 60 | 2025-02-01 | 2025-01-24 |
| Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI) - Dysbiosis, Gastroesophageal Reflux Disease (GERD) | Phase 4 | Completed | Seoul National University Hospital | 80 | 2024-07-18 | 2026-10-01 |
| Effect of Probiotic on Gut Microbiome and Bacterial Translocation in Healthy Asian Volunteers Colonic lavage with polyethylene glycol, Probiotic, Antibiotic - Dysbiosis | Phase 4 | Unknown | Changi General Hospital | 32 | 2021-03-10 | 2022-03-22 |
| Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial Estradiol Vaginal Insert - HIV Infection, Vaginal Atrophy | Phase 4 | Completed | Kerry Murphy | 60 | 2020-09-01 | 2025-03-14 |
| The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication Bismuth Subcitrate 120 MG Oral Tablet, Lactobacillus acidophilus and Bifidobacterium lactis Bb12, Esomeprazole 40mg - Helicobacter Pylori Infection, Dysbiosis | Phase 4 | Enrolling by invitation | National Cheng-Kung University Hospital | 312 | 2020-05-06 | 2024-06-24 |
| Vitamin D and Prebiotics for Intestinal Health in Cystic Fibrosis Vitamin D3, Placebo vitamin D3, Inulin - Cystic Fibrosis, Dysbiosis | Phase 4 | Completed | Emory University | 40 | 2020-03-13 | 2024-02-07 |
| Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection. SCALE AND ROOT PLANING, ADJUNTIVE ANTIBIOTICS, MICROBIAL SAMPLING - Chronic Periodontitis, Periodontal Bone Loss | Phase 4 | Completed | University of Valencia | 64 | 2019-02-08 | 2026-05-12 |
| PPI and Microbiome in Healthy Volunteers and Functional Dyspepsia Pantoprazole 40mg, PPI withdrawal - Dysbiosis | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 79 | 2018-04-23 | 2020-09-28 |
Aging, Premature (2) · Atrophic Vaginitis (2) · HIV Infections (2) · Surgical Wound Infection (2) · Vaginitis (2) · Acquired Immunodeficiency Syndrome (1) · Acute Coronary Syndrome (1) · Alveolar Bone Loss (1) · Chronic Periodontitis (1) · Cystic Fibrosis (1) · Dental Plaque (1) · Gastroesophageal Reflux (1) · Myocardial Infarction (1) · Periodontitis (1)
Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Infections (4) · Blood-Borne Infections (2) · Communicable Diseases (2) · Digestive System Diseases (2) · Disease Attributes (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Genital Diseases (2) · Genital Diseases, Female (2) · Immune System Diseases (2) · Immunologic Deficiency Syndromes (2) · Lentivirus Infections (2) · Postoperative Complications (2)
Probiotics (3) · Estradiol (2) · Rifaximin (2) · Anti-Bacterial Agents (1) · Cholecalciferol (1) · Esomeprazole (1) · Inulin (1) · Lacteol (1) · Metronidazole (1) · Pantoprazole (1) · Polyethylene Glycols (1) · Proton Pump Inhibitors (1) · Replens (1) · Root Planing (1) · Standard of Care (1)
Acibadem Maslak Hospital (1) · Albert Einstein College of Medicine (1) · Boston Medical Center (1) · Changi General Hospital (1) · Collegium Medicum w Bydgoszczy (1) · Emory University (1) · Kerry Murphy (1) · National Cheng-Kung University Hospital (1) · Seoul National University Hospital (1) · Universitaire Ziekenhuizen KU Leuven (1) · University of Valencia (1)
United States (5) · Belgium (1) · Poland (1) · Singapore (1) · South Korea (1) · Spain (1) · Taiwan (1) · Thailand (1) · Turkey (Türkiye) (1)
Kerry J Murphy, MD (2) · Ayesha Abdeen, MD (1) · Emanuele Chisari, Dr., Ph.D. (1) · Hsiu-Chi Cheng, PhD (1) · Jacek Kubica, Prof. (1) · Javad Parvizi, Prof. Dr. (1) · Tiing Leong Ang (1) · Tim Vanuytsel, MD PhD (1) · Vin Tangpricha, MD (1)
PMID 33346007, PMID 36463082, PMID 38500841
2019 (1), K23AG062400 (1), R01AG102277 (1)