2 completed, 2 terminated, 1 active not recruiting, 1 not yet recruiting. 3 Phase 2, 1 Early Phase 1, 1 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Active not recruiting 1, Completed 1, Terminated 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Not applicable | 1 | Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Replens: new trials by email Literature Review of Replens trials Research Report on Replens
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV Vaginal estradiol tablets, Vaginal moisturizer - Menopausal Complaints, Vaginal Atrophy | Phase 4 | Not yet recruiting | Albert Einstein College of Medicine | 62 | 2026-09-01 | 2026-07-28 |
| Vaginal Dehydroepiandrosterone (DHEA) in Postmenopausal Breast Cancer Survivors on Aromatase Inhibitors Vaginal Dehydroepiandrosterone, Vaginal Polycarbophil Moisturizer - Vaginal Atrophy, Postmenopausal Symptoms | Phase 2 | Terminated | University of Arkansas | 8 | 2021-06-07 | 2024-11-27 |
| GSM (Genitourinary Syndrome Of Menopause) Management In Breast Cancer Survivors Replens and coconut oil - Genitourinary Abnormality, Breast Cancer Female | Early Phase 1 | Terminated | Alta Bates Summit Medical Center | 14 | 2016-11-18 | 2018-07-26 |
| The Vaginal Health Trial Vagifem, Replens, Placebo tablet - Atrophy of Vagina, Menopause | Phase 3 | Completed | Fred Hutchinson Cancer Center | 302 | 2016-04-01 | 2018-07-12 |
| Randomized Trial of Maternal Progesterone Therapy Progesterone, Vaginal lubricant - Congenital Heart Disease, Periventricular Leucomalacia | Phase 2 | Completed | Children's Hospital of Philadelphia | 102 | 2014-07-01 | 2023-08-09 |
| REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy ESTRING, Replens, Vagifem - Estrogen Receptor Positive Breast Cancer, Breast Cancer | Phase 2 | Active not recruiting | Polly A. Niravath, MD | 33 | 2013-09-01 | 2026-01-28 |
| Vaginal Progesterone as a Treatment for Women Active Preterm Labor Vaginal progesterone gel, Placebo vaginal gel - Labor, Premature | Not applicable | Withdrawn | University of Rochester | 2010-07-01 | 2012-10-01 |
Dyspareunia (2) · Acquired Immunodeficiency Syndrome (1) · Aging, Premature (1) · Atrophic Vaginitis (1) · Breast Neoplasms (1) · Dysbiosis (1) · Dysuria (1) · HIV Infections (1) · Heart Defects, Congenital (1) · Leukomalacia, Periventricular (1) · Obstetric Labor, Premature (1) · Urinary Tract Infections (1) · Urogenital Abnormalities (1) · Vaginitis (1)
Albert Einstein College of Medicine (1) · Alta Bates Summit Medical Center (1) · Children's Hospital of Philadelphia (1) · Fred Hutchinson Cancer Center (1) · Polly A. Niravath, MD (1) · University of Arkansas (1) · University of Rochester (1)
United States (7)
Andrea Z LaCroix, PhD (1) · Caroline Mitchell, MD, MPH (1) · Gloria Richard-Davis, MD (1) · J. William Gaynor, MD (1) · Katherine A Guthrie, PhD (1) · Kerry J Murphy, MD (1) · Polly Niravath, MD (1) · Susan D Reed, MD (1) · Tulin Ozcan, MD (1) · Uma Suryadevara, MD (1)
PMID 23481118, PMID 29554173, PMID 29738424, PMID 30994576, PMID 33367735, PMID 33675793, PMID 35353163, PMID 36374501, PMID 37402281, PMID 38805228
R01AG102277 (1)