104 completed, 16 unknown, 7 withdrawn, 4 terminated. 58 Not applicable, 30 Phase 2, 20 Phase 3, 10 Phase 1, 10 Phase 4.
Follow Dry Eye Syndrome: new trials by email Literature Review of Dry Eye Syndrome trials Research Report on Dry Eye Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LacriFill Canalicular Occlusion for Dry Eye After LASIK LacriFill Canalicular Filler - Dry Eye Syndrome | Not applicable | Not yet recruiting | Mann Eye Institute | 75 | 2026-12-09 | 2026-11-03 |
| Effects of AffronEye®/ Crocuvis+® on Dry Eye Syndrome Saffron extract (Crocus sativus), Placebo - Dry Eye Syndrome | Not applicable | Withdrawn | University of Alicante | 2025-10-10 | 2026-05-19 | |
| Autologous Serum Eye Drops in Dry Eye Syndrome Autologous Serum Eye Drop - Autologous Serum Eye Drops, Dry Eye Syndrome | Not applicable | Recruiting | The General Authority for Teaching Hospitals and Institutes | 70 | 2025-09-01 | 2025-12-22 |
| A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA) ABBV-319 - Dry Eye Syndrome, Systemic Lupus Erythematosus | Phase 1 | Recruiting | AbbVie | 36 | 2025-08-26 | 2026-08-10 |
| Comparing Effect of Hylorunic Acid and Lipid-coated Carbomer Gel on Dry Eyes After Phacoemulsification in DP Preoperative dry eyes, Lipid coated carbomer gel eye drops - Dry Eye Syndrome | Not applicable | Active not recruiting | Superior University | 64 | 2025-03-20 | 2025-04-06 |
| Efficacy of Warm Compress Therapy in Enhancing Tear Film Quality and Reducing Postoperative DES Warm Compress, Standard Care - Dry Eye Syndrome | Not applicable | Active not recruiting | Superior University | 54 | 2025-03-20 | 2025-04-06 |
| Performance and Safety of T2769 Versus Hylo-Forte® in the Treatment of Moderate to Severe Dry Eye Syndrome. T2769, Hylo-Forte® - Dry Eye Syndrome | Not applicable | Completed | Laboratoires Thea | 74 | 2024-09-17 | 2026-01-02 |
| Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome TBDESJS, Acupuncture - Dry Eye Syndrome, Sjogren's Syndrome | Not yet recruiting | Taipei Veterans General Hospital, Taiwan | 220 | 2024-07-01 | 2024-06-26 | |
| A Study to Assess Symptom Relief and Product Tolerability of ABBV-444 Drops in Adult Participants ABBV-444 - Dry Eye Syndrome | Phase 3 | Completed | AbbVie | 40 | 2023-06-27 | 2024-10-15 |
| Evaluation of Performance and Safety of Carbopol 980 NF 0.2%- Based Medical Device in the Management of Patients With Glaucomar or Ocular Hypertension and Concomitant Dry Eye Syndrome on Multiple Long-term Topical Hypotensive Therapy Iridium A Gel - Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome | Not applicable | Terminated | Fidia Farmaceutici s.p.a. | 65 | 2023-06-14 | 2026-02-25 |
| VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome Chinese herbal tea VGH-DESJS-1 - Dry Eye Syndrome, Sjogren's Syndrome | Not applicable | Completed | Taipei Veterans General Hospital, Taiwan | 100 | 2023-04-01 | 2024-01-26 |
| Observational Study on the Improvement of Dry Eye Syndrome, Treatment Satisfaction, and Intraocular Tolerance With Diquasol Eye Drops Dry Eye Syndrome | Unknown | Hanlim Pharm. Co., Ltd. | 2000 | 2023-02-08 | 2023-12-15 | |
| Effect of an Educational Program on Health-related Outcomes of Patients With Dry Eye Syndrome Educational Program - Dry Eye Syndrome | Not applicable | Completed | Alexandria University | 60 | 2023-01-15 | 2024-03-01 |
| Clinical Trial to Assess the Effectiveness of I+Med's DayDrop Advanced Ophthalmic Drop DayDrop Advanced ophthalmic drop - Dry Eye Syndrome | Not applicable | Completed | i+Med S.Coop. | 45 | 2022-12-21 | 2025-04-01 |
| To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome Acupuncture, Oral microbiota, Schirmer's test - Dry Eye Syndrome, Xerophthalmia | Not applicable | Unknown | Taipei Veterans General Hospital, Taiwan | 120 | 2022-12-06 | 2022-12-13 |
| Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank Whole-genome genotyping, Whole-genome sequencing, TCM pattern - Dry Eye Syndrome, Sjogren's Syndrome | Not yet recruiting | Taipei Veterans General Hospital, Taiwan | 100000 | 2022-10-01 | 2022-08-11 | |
| Probiotic in Dry Eye Syndromes Ophthalmic Probiotic, Opthalmic Placebo, Oral Probiotic Capsule - Dry Eye Syndrome | Phase 2 | Completed | Shiraz University of Medical Sciences | 40 | 2021-07-01 | 2023-03-27 |
| Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy Study Pro-ocular™ Topical Gel, Placebo Topical Gel - Dry Eye Syndrome, Keratoconjunctivitis Sicca | Phase 2 | Unknown | PharmaDax Inc. | 80 | 2021-05-20 | 2021-05-14 |
| Objective Measurement With TCM Pattern for AIDDES Traditional Chinese Medicine pattern, Traditional Chinese Medicine tongue diagnosis, Heart rate variability - Sjögren's Syndrome, Systemic Lupus Erythematosus | Unknown | Taipei Veterans General Hospital, Taiwan | 1800 | 2021-02-01 | 2022-12-13 | |
| Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery The study will include three arms, one non interventional and 2 interventions. The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod) - Dry Eye Disease, Dry Eye Syndrome | Phase 3 | Unknown | Fundación Oftalmológica Los Andes | 100 | 2021-01-15 | 2021-01-15 |
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Dry Eye Syndromes (139) · Keratoconjunctivitis Sicca (9) · Sjogren's Syndrome (7) · Xerophthalmia (7) · Meibomian Gland Dysfunction (4) · Blepharitis (3) · Eye Pain (3) · Lupus Erythematosus, Systemic (3) · Glaucoma (2) · Keratitis sicca (2) · Keratoconjunctivitis (2) · Rosacea (2) · Alzheimer Disease (1) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1)
Eye Diseases (138) · Lacrimal Apparatus Diseases (138) · Conjunctival Diseases (19) · Conjunctivitis (12) · Corneal Diseases (12) · Immune System Diseases (12) · Keratitis (12) · Skin and Connective Tissue Diseases (12) · Keratoconjunctivitis (10) · Autoimmune Diseases (9) · Connective Tissue Diseases (9) · Arthritis (7) · Eyelid Diseases (7) · Joint Diseases (7) · Mouth Diseases (7)
Cyclosporins (5) · Ophthalmic Solutions (3) · thymosin beta(4) (3) · Acupuncture Therapy (2) · Carboxymethylcellulose Sodium (2) · Glycerol (2) · Hyaluronic Acid (2) · Intense Pulsed Light Therapy (2) · Polysorbates (2) · Visomitin (2) · cenegermin (2) · isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate (2) · recoflavone (2) · Adrenal Cortex Hormones (1) · Blood Cell Count (1)
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Gail Torkildsen, MD (8) · Ching-Mao Chang, M.D., Ph.D. (4) · Gerhard Garhoefer, MD (3) · Chang Ching-Mao, M.D., Ph.D. (2) · James P. McCulley, M.D. (2) · John Lonsdale, MD (2) · Lawrence T Friedhoff, MD, PhD (2) · Wei-Li Chen (2) · Abayomi Ogundele, PharmD (1) · Alan L Robin, MD (1) · Anant Sharma, FRCOphth (1) · Blair Boehmer, MD (1)
PMID 27893109, PMID 10434857, PMID 10487957, PMID 10768324, PMID 10815152, PMID 11009316, PMID 11567963, PMID 11685055, PMID 11815344, PMID 11879137, PMID 12006334, PMID 12657587, PMID 12786773, PMID 14508260, PMID 15090417, PMID 15219876, PMID 15489495, PMID 15733983, PMID 16004673, PMID 16102833, PMID 16785864, PMID 17102664, PMID 17262232, PMID 17508121, PMID 17525185, PMID 18234997, PMID 18813071, PMID 18848318, PMID 19006483, PMID 19128374, PMID 19218606, PMID 19506189, PMID 19730088, PMID 19850844, PMID 20155706, PMID 20393114, PMID 20597641, PMID 20631232, PMID 21792057, PMID 22232476, PMID 22606467, PMID 22670856, PMID 22928476, PMID 22955119, PMID 23226002, PMID 23402632, PMID 2352956, PMID 24030535, PMID 25650419, PMID 25659956
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