4 completed, 2 terminated, 1 recruiting. 5 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 3, Recruiting 1, Terminated 1 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2 RGN-259, Placebo - Neurotrophic Keratopathy | Phase 3 | Recruiting | ReGenTree, LLC | 70 | 2023-04-11 | 2025-12-23 |
| Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3 RGN-259, Placebo - Dry Eye Syndromes, Dry Eye | Phase 3 | Completed | ReGenTree, LLC | 700 | 2019-05-24 | 2026-08-28 |
| Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2 RGN-259, Placebo - Dry Eye Syndrome | Phase 3 | Completed | ReGenTree, LLC | 601 | 2016-11-01 | 2026-10-21 |
| Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 RGN-259, Placebo - Neurotrophic Keratopathy | Phase 3 | Terminated | ReGenTree, LLC | 18 | 2015-09-17 | 2023-08-30 |
| Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1 RGN-259, Placebo - Dry Eye Syndrome | Phase 2 / Phase 3 | Completed | ReGenTree, LLC | 317 | 2015-09-01 | 2019-10-17 |
| Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye Thymosin beta 4, Placebo - Dry Eye Syndrome, Dry Eye | Phase 2 | Completed | ReGenTree, LLC | 72 | 2011-08-01 | 2015-07-10 |
| A Phase 2 Study of the Safety and Efficacy of Thymosin Beta 4 for Treating Corneal Wounds Thymosin Beta 4 (Tβ4), Placebo - Diabetes | Phase 2 | Terminated | ReGenTree, LLC | 12 | 2007-12-01 | 2015-07-08 |
Dry Eye Syndromes (4) · Diabetes Mellitus (1)
thymosin beta(4) (6)
United States (6) · Italy (1) · Poland (1) · Spain (1)
Gail Torkildsen, MD (3) · David R Crockford (1)