36 completed, 9 terminated, 6 recruiting, 5 unknown. 20 Phase 2, 17 Phase 1, 14 Phase 3, 11 Phase 4, 10 Not applicable.
Follow Loperamide: new trials by email Literature Review of Loperamide trials Research Report on Loperamide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| Tirzepatide for Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008) Tirzepatide, Loperamide, Diphenoxylate/Atropine - Pouch, Ileal, Pouches, Ileoanal | Phase 4 | Not yet recruiting | University of North Carolina, Chapel Hill | 20 | 2026-09-01 | 2026-08-10 |
| Rash & Diarrhea Prophylaxis With Capivasertib Capivasertib, Loperamide, Fulvestrant - Metastatic HR+/HER2- Breast Cancer | Phase 2 | Recruiting | Maryam Lustberg | 108 | 2026-08-15 | 2026-07-29 |
| Probiotics for Prevention of Neratinib-Induced Diarrhea in Breast Cancer Patients Probiotics, Placebo, Loperamide - HER2-positive Breast Cancer, Diarrhea Caused by Drug | Not applicable | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 308 | 2025-08-07 | 2026-06-17 |
| Sacituzumab Govitecan for Relapsed Ovarian, Endometrial, and Cervical Carcinomas Sacituzumab Govitecan, EKG, Brain MRI - Recurrent Platinum Resistant Epithelial Ovarian Carcinoma, Recurrent Epithelial Endometrial Carcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 2 | 2025-06-09 | 2026-01-21 |
| Immunochemotherapy ± Salvage Chemoradiation for Local Recurrence of Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy Sintilimab Combined With Docetaxel Monotherapy - Esophageal Squamous Cell Carcinoma (ESCC) | Phase 3 | Enrolling by invitation | Ye jinjun | 79 | 2024-08-01 | 2025-06-12 |
| Antibiotics and Vaccine Immune Responses Study BCG vaccine, Yellow Fever vaccine, Vancomycin Oral Capsule - Vaccine Response Impaired | Phase 4 | Recruiting | South Australian Health and Medical Research Institute | 348 | 2023-11-23 | 2026-09-17 |
| Preventive stRategy for IMMU132-relatED AEs in TNBC or Luminal Breast Cancer- PRIMED Sacituzumab govitecan, Loperamide, Granulocyte Colony-Stimulating Factor - Triple Negative Breast Cancer, Breast Cancer | Phase 2 | Completed | MedSIR | 50 | 2023-02-06 | 2025-12-04 |
| Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct Rifaximin 550 MG, Azithromycin 500 MG, Loperamide - Diarrhoea;Acute, Diarrhea Travelers | Phase 4 | Recruiting | Henry M. Jackson Foundation for the Advancement of Military Medicine | 150 | 2022-10-28 | 2025-05-31 |
| Multi-System Analysis of Opioid Receptor Binding Carfentanil, C-11, Naloxone, Loperamide Hydrochloride - Healthy, Opioid Use Disorder | Phase 1 | Active not recruiting | University of Pennsylvania | 25 | 2022-09-20 | 2026-03-30 |
| Three Antidiarrheal Strategies in HER2+/HR+ Early Breast Cancer Patients Treated With Extended Adjuvant Neratinib Neratinib, Loperamide, Colesevelam - Early-stage Breast Cancer, HER2 Positive Breast Cancer | Phase 2 | Active not recruiting | Spanish Breast Cancer Research Group | 177 | 2022-08-31 | 2025-04-01 |
| Effect of Montmorillonite Power or Loperamide on the Pharmacokinetics of Pyrotinib in Healthy Subjects pyrotinib tablet, Montmorillonite Power, Loperamide - HER2-positive Recurrent / Metastatic Breast Cancer | Phase 1 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 36 | 2022-03-08 | 2022-12-23 |
| Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients Fecal Microbiota Transplantation, Loperamide - Colitis, Diarrhea | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 40 | 2021-02-01 | 2026-09-18 |
| Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Selinexor, Temozolomide, Generic Radiation therapy (RT) - Gliosarcoma, Newly Diagnosed | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 11 | 2020-07-07 | 2026-01-23 |
| A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib Neratinib, Capecitabine, Loperamide - HER2 Amplified Breast Cancer | Phase 2 | Completed | Puma Biotechnology, Inc. | 6 | 2020-06-30 | 2023-02-10 |
| Impact of Dietary Fiber as Prebiotics on Chemotherapy-related Diarrhea in Patients With Gastrointestinal Tumors Prebiotic Fiber Supplement + loperamide hydrochloride capsule, Maltodextrin + loperamide hydrochloride capsule - Chemotherapy-related Diarrhea | Not applicable | Withdrawn | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2020-06-30 | 2021-08-06 | |
| Prevention and Treatment of Pyrrolitinib-associated Diarrhea Loperamide, Loperamide and golden bifid, Loperamide and montmorillonite powder - Breast Cancer | Phase 2 / Phase 3 | Unknown | Tianjin Medical University Cancer Institute and Hospital | 470 | 2020-05-16 | 2021-02-03 |
| A Drug-drug Interaction Trial of Loperamide Pharmacokinetics Effect on Pyrotinib Maleate pyrotinib maleate, Loperamide - Healthy Participants | Phase 1 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 18 | 2020-04-13 | 2022-10-28 |
| A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants Loperamide, Placebo, Moxifloxacin - Healthy Participants | Phase 1 | Completed | Janssen Research & Development, LLC | 66 | 2020-01-17 | 2025-03-30 |
| A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced Malignancies Poziotinib Hydrochloride, Loperamide - Breast Cancer, Colorectal Cancer | Phase 2 | Terminated | Spectrum Pharmaceuticals, Inc | 1 | 2019-12-23 | 2024-03-13 |
Showing 20 of 66. Sign in to see all of them.
Breast Neoplasms (12) · Diarrhea (12) · Fecal Incontinence (6) · Rectal Neoplasms (3) · Colorectal Neoplasms (2) · Intestinal Obstruction (2) · Ovarian Neoplasms (2) · Sarcoma, Alveolar Soft Part (2) · Carcinoma in Situ (1) · Carcinoma, Non-Small-Cell Lung (1) · Chondrosarcoma (1) · Clostridium Infections (1) · Colitis (1) · Colitis, Ulcerative (1) · Colonic Neoplasms (1)
National Cancer Institute (NCI) (5) · Eli Lilly and Company (3) · Boehringer Ingelheim (2) · Jiangsu HengRui Medicine Co., Ltd. (2) · Johnson & Johnson Consumer and Personal Products Worldwide (2) · McNeil AB (2) · Puma Biotechnology, Inc. (2) · The University of Texas Health Science Center, Houston (2) · University Hospital, Linkoeping (2) · University Medicine Greifswald (2) · University of North Carolina, Chapel Hill (2) · AEterna Zentaris (1) · Cedars-Sinai Medical Center (1) · Centre Francois Baclesse (1) · Centre de recherche du Centre hospitalier universitaire de Sherbrooke (1)
United States (28) · China (8) · Germany (4) · Mexico (4) · Spain (4) · Belgium (3) · Canada (3) · France (3) · Australia (2) · Austria (2) · Djibouti (2) · Honduras (2) · Kenya (2) · Russia (2) · South Korea (2)
Alice P Chen, M.D. (2) · Adrienne D Bonham, MD (1) · Alayne D Markland, DO MSc (1) · Alessandra C Gasior, DO (1) · Bhoomi Mehrotra, MD (1) · Charles D. Ericsson, MD (1) · Daniel M Musher, MD (1) · David Lynn (1) · Dejka Araujo, MD (1) · Dolly Parasrampuria, PhD (1) · Edward Barnes, MD (1)
PMID 24919854, PMID 26541878, PMID 28627732, PMID 29029033, PMID 31320277, PMID 31615937, PMID 32464281, PMID 33558725, PMID 34189178, PMID 34413142, PMID 35076812, PMID 35223458, PMID 36302173, PMID 36702070, PMID 39187401, PMID 40341091, PMID 40433999, PMID 40439882, PMID 42735684
2019 (3), 2014 (1), 2015 (1), U01HD069031 (1), U10HD041261 (1), U10HD041267 (1), U10HD054214 (1), U10HD054215 (1), U10HD069006 (1), U10HD069010 (1), U10HD069013 (1), U10HD069025 (1)