109 completed, 29 unknown, 8 recruiting, 8 terminated. 66 Not applicable, 41 Phase 3, 28 Phase 2, 20 Phase 4, 12 Phase 1.
Follow this drug Literature Review of Zinc trials Research Report on Zinc
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash - Diabetes Type 2, Periodontal Disease | Phase 4 | Enrolling by invitation | Colgate Palmolive | 10000 | 2026-05-26 | 2026-09-03 |
| Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial 25 mg/day zinc, 40 mg/day zinc - Sickle Cell Disease | Phase 2 | Recruiting | University of California, San Francisco | 34 | 2026-02-14 | 2026-03-13 |
| Zinc Supplementation and Infections in Older Medical Patients Zinc (zinc sulphate) - Older Adults (65 Years and Older), Medical Patients in the Emergency Department | Not applicable | Recruiting | Herlev Hospital | 8000 | 2026-02-01 | 2026-05-29 |
| Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection BOTOX 100U in normal saline with zinc, BOTOX 100U in normal saline with placebo - Hyperactive Masseter Muscle | Not applicable | Not yet recruiting | Latakia University | 20 | 2025-12-01 | 2025-12-08 |
| Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis Zinc, Placebos for zinc and nicotinamide riboside, Nicotinamide riboside - Idiopathic Pulmonary Fibrosis | Phase 2 | Recruiting | Cedars-Sinai Medical Center | 60 | 2025-11-03 | 2025-11-10 |
| Zinc Sulphate in Treatment Fibrosis in HBV Patient Receiving Antiviral Therapy Entecavir (ETV), Zinc (zinc sulphate) - Liver Fibroses, HBV (Hepatitis B Virus) | Phase 2 | Not yet recruiting | Tanta University | 44 | 2025-09-01 | 2025-08-28 |
| COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY Zinc sulfate, Probiotic lactobacillus rhamnosus GG - Indirect Hyperbilirubinemia, Neonatal | Phase 2 | Recruiting | Quaid-e-Azam Medical College | 110 | 2025-08-07 | 2025-08-05 |
| Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G/A SEPP1 Polymorphism zinc, selenium, and L-tyrosine in SEPP1, Placebo - Thyrotoxicosis | Not applicable | Not yet recruiting | S.LAB (SOLOWAYS) | 150 | 2025-07-30 | 2025-06-08 |
| Efficacy of a 2'-Fucosylactose-based Food Supplement on the Prevention of Respiratory and Gastrointestinal Infections. Vitamin + Zinc + micronutrient mixture, Placebo - Gastroenteric Tract, Respiratory Tract | Not applicable | Recruiting | University of Bari | 100 | 2025-04-17 | 2025-07-09 |
| Tralement Versus a Fixed-dose Trace Element Combination Product to Evaluate Manganese Safety Tralement, Fixed-dose trace element combination product of zinc, copper, and selenious acid - Manganese Safety in Adults | Phase 4 | Withdrawn | American Regent, Inc. | 2025-02-01 | 2025-02-12 | |
| The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease PPI (proton pump inhibitor), Probiotic, Zinc - Gastro-oesophageal Reflux Disease | Phase 4 | Not yet recruiting | Ain Shams University | 120 | 2024-11-01 | 2024-10-29 |
| A Comprehensive Analysis of the Comparative Efficacy of Multimodal Diarrhea Therapies in the Paediatric Population Prebiotic, Duration, Smecta - To Assess the Mean Time of Resolution of Diarrhea | Early Phase 1 | Unknown | Combined Military Hospital Multan | 100 | 2024-09-15 | 2024-09-19 |
| Evaluation of Butyrate Effect on Diarrhea Food Supplement DBZ (acronym for: DIBUZIN) containing calcium butyrate, vitamin D and zinc,, Placebo - Antibiotic-associated Diarrhea | Not applicable | Unknown | University of Padova | 50 | 2024-06-15 | 2025-05-21 |
| The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction platelet-rich plasma combined with hyaluronic acid, Zinc Gluconate 10 MG Oral Tablet, 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil - Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis), Effect of Drug | Phase 3 | Unknown | Taichung Veterans General Hospital | 80 | 2024-03-20 | 2024-03-04 |
| Prophylactic Oral Vitamin D and Zinc for Radiation-Induced Oral Mucositis in Head and Neck Cancer Vitamin D - Oncology | Unknown | Assiut University | 100 | 2023-11-01 | 2023-11-07 | |
| Vitamin C and Zinc in Patients With Enterocutaneous Fistulas. Low-dose vitamin C and zinc, High-dose vitamin C and zinc - Enterocutaneous Fistulas | Not applicable | Recruiting | Hospital Juarez de Mexico | 76 | 2023-08-01 | 2023-08-24 |
| Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients with Ventriculitis Probiotic Formula, Zinc - Ventriculitis, Infectious | Phase 4 | Recruiting | Ain Shams University | 140 | 2023-07-01 | 2025-02-25 |
| The Impact of Preoperative Supplementation of Zinc Zinc - Surgery, Nutrition Disorders | Not applicable | Completed | Cairo University | 1 | 2023-04-01 | 2024-02-09 |
| Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces Boulardii in Acute Watery Diarrhea in Paediatric Patients Bacillus clausii, Saccharomyces boulardii, Zinc - Acute Watery Diarrhea | Not applicable | Completed | RESnTEC, Institute of Research | 60 | 2023-04-01 | 2024-08-12 |
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Diarrhea (21) · COVID-19 (16) · Pneumonia (13) · Malnutrition (9) · Coronavirus Infections (6) · Diabetes Mellitus, Type 2 (6) · Malaria (6) · Respiratory Tract Infections (6) · Child Nutrition Disorders (3) · Infections (3) · Neoplasms (3) · Sepsis (3) · Squamous Cell Carcinoma of Head and Neck (3) · Anemia (2) · Anemia, Sickle Cell (2)
International Centre for Diarrhoeal Disease Research, Bangladesh (8) · Society for Applied Studies (5) · Ain Shams University (4) · Emory University (4) · Harvard School of Public Health (HSPH) (4) · Johns Hopkins Bloomberg School of Public Health (4) · Ministry of Health, Saudi Arabia (4) · Universitas Indonesia (4) · Washington University School of Medicine (4) · Cairo University (3) · Centre For International Health (3) · Colgate Palmolive (3) · ProgenaBiome (3) · Arak University of Medical Sciences (2) · Brooklyn ImmunoTherapeutics, LLC (2)
United States (27) · India (12) · Egypt (11) · Bangladesh (10) · Brazil (8) · Italy (7) · Indonesia (6) · Tanzania (6) · Canada (5) · Israel (5) · France (4) · Malawi (4) · Mexico (4) · Pakistan (4) · Spain (4)
Nita Bhandari, PhD (5) · Mark J Manary, MD (3) · Sabine Hazan, MD (3) · Maharaj K Bhan, MD (2) · Robert E Black, MD, MPH (2) · Umesh Jain, MD (2) · Adolfo D. Rodriguez-Carrizalez, M.Sc. (1) · Agussalim Bukhari, MD.Ph.D (1) · Ahmed E Shouman, Professor (1) · Ahmed G Elgazzar, M.D. (1) · Ahmed M Abdul Ghani, MD (1) · Aidah Baso, MD. Ph.D (1) · Albert Hakaim, MD (1)
PMID 36994923, PMID 10801969, PMID 11097601, PMID 11387176, PMID 11470690, PMID 11594942, PMID 11594943, PMID 11925463, PMID 12042580, PMID 12052800, PMID 15136320, PMID 15534261, PMID 15557412, PMID 15808240, PMID 16254536, PMID 16606880, PMID 16877067, PMID 17132678, PMID 17344250, PMID 17502507, PMID 17593956, PMID 17684211, PMID 17846363, PMID 18184631, PMID 18201681, PMID 18237394, PMID 18296460, PMID 18450870, PMID 18582194, PMID 18687132, PMID 18779490, PMID 19174830, PMID 19365036, PMID 19491388, PMID 19508997, PMID 19553296, PMID 19828715, PMID 19904293, PMID 20038852, PMID 20107146, PMID 20176858, PMID 20237063, PMID 20298571, PMID 20375190, PMID 20431391, PMID 20455705, PMID 20470442, PMID 20539208, PMID 20546583, PMID 20605091
K23AA018399 (1), K23HL076468 (1), P30CA138292 (1), R01DA014966 (1), R01HD038327 (1), R01HD045430 (1), R01HL125042 (1), R34HL117351 (1), U01HD040657 (1)