42 completed, 13 unknown, 6 recruiting, 3 withdrawn. 26 Not applicable, 22 Phase 2, 9 Phase 3, 2 Phase 1, 1 Phase 4.
Follow Diabetic Polyneuropathy: new trials by email Literature Review of Diabetic Polyneuropathy trials Research Report on Diabetic Polyneuropathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PULP SENSIBILITY AND MASSETER INHIBITORY REFLEX IN DIABETIC POLYNEUROPATHY Diabetic Polyneuropathy, Healthy Individuals (Controls) | Not yet recruiting | Bezmialem Vakif University | 108 | 2026-04-15 | 2026-04-03 | |
| Serum Neurofilament Light Chain Levels and Neuropathy Severity in Diabetic Polyneuropathy Blood Sample Collection and Clinical Assessment - Diabetic Polyneuropathy | Completed | Kanuni Sultan Suleyman Training and Research Hospital | 88 | 2026-03-25 | 2026-08-20 | |
| The Effect of Oral DLBS1033 in Patients With Diabetic Polyneuropathy DLBS1033, Placebo Comparator: Placebo + Standard Therapy - Diabetic Polyneuropathy, Peripheral Nervous System Diseases | Phase 2 / Phase 3 | Not yet recruiting | Universitas Sebelas Maret | 34 | 2026-03-01 | 2026-03-16 |
| Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients Conventional physical therapy program, Sham therapy, Transcutaneous auricular vagus nerve stimulation - Transcutaneous Vagal Nerve Stimulation (tVNS), Diabetic Polyneuropathy | Not applicable | Recruiting | Cairo University | 40 | 2026-01-01 | 2026-02-12 |
| Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Diabetic Polyneuropathy Type 2 Diabetes Mellitus, Diabetic Polyneuropathy | Completed | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 30 | 2025-07-01 | 2026-10-21 | |
| Peripheral Magnetic Stimulation With Balance Training to Decrease Fall Risks in Diabetic Polyneuropathy Peripheral magnetic stimulation, Balance training, Sham stimulation - Diabetic Polyneuropathy | Phase 2 | Recruiting | Queen Savang Vadhana Memorial Hospital, Thailand | 40 | 2025-06-10 | 2026-08-18 |
| Impact of Diabetic Polyneuropathy on Carpal Tunnel Syndrome: Shear Wave Elastography, Ultrasound, and Hand Function Carpal Tunnel Syndrome (CTS), Diabetic Polyneuropathy | Completed | Ankara Etlik City Hospital | 84 | 2025-04-18 | 2026-03-27 | |
| Effect of Feldenkrais Method in Enhancing Postural Control for Patients with Diabetic Polyneuropathy The Feldenkrais-based intervention, conventional balance training program - Diabetic Polyneuropathy | Phase 1 | Enrolling by invitation | Cairo University | 24 | 2025-03-30 | 2025-04-01 |
| The Effect of Sleep Hygiene Education on Sleep Quality and Quality of Life in Patients With Painful Diabetic Polyneuropathy sleep hygiene education, Control - Diabetic Polyneuropathy, Sleep Hygiene | Not applicable | Completed | Trakya University | 24 | 2025-01-07 | 2026-06-15 |
| Investigation of Ultrasonographic Measurements of Lower Extremity Nerves in Type 2 Diabetes Patients With Peripheral Polyneuropathy Ultrasonography, Biodex Balance System, Douleur Neuropathique 4 (DN4) Pain Scale - Diabetes, Diabetic Polyneuropathy | Recruiting | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | 86 | 2025-01-01 | 2025-09-12 | |
| A Study of CGRP Monoclonal Antibody to Treat Diabetic Neuropathy Eptinezumab, Placebo - Diabetic Polyneuropathy | Phase 2 | Withdrawn | Mayo Clinic | 2025-01-01 | 2025-03-06 | |
| Driving with Neuropathy Visual feedback training - Diabetic Polyneuropathy, Diabetes Mellitus, Type 2 | Not applicable | Recruiting | Manchester Metropolitan University | 115 | 2024-10-25 | 2024-12-18 |
| Combined Effects of Foot-Ankle Therapeutic Exercises and Mindful Walking in Patients With Diabetic Polyneuropathy Foot-Ankle therapeutic exercises and Mindful Walking., Standard care with Mindful walking. - Diabetic Polyneuropathy | Not applicable | Recruiting | Riphah International University | 38 | 2024-10-17 | 2025-11-25 |
| The Effect of Alpha Lipoid Acid and Vitamin B Preparation on Diabetic Polyneuropathy in Type 2 Diabetes Mellitus Patient Alpha-Lipoic Acid/Vitamin/Mineral Supplement PolyMVA - Diabetic Polyneuropathy | Phase 2 | Unknown | Universiti Sains Malaysia | 76 | 2024-05-27 | 2024-08-23 |
| Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS) Percutaneous transluminal angioplasty - Diabetic Foot, Diabetes Mellitus | Not applicable | Recruiting | Heinrich-Heine University, Duesseldorf | 200 | 2024-02-01 | 2026-02-04 |
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study Validity and reliability of outcome measures in polyneuropathy, Healthy controls - Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy | Active not recruiting | Copenhagen University Hospital, Rigshospitalet | 520 | 2023-09-23 | 2026-09-15 | |
| Neuromuscular Electrical Stimulation For The Treatment of Diabetic Neuropathy Revitive Medic Coach (Actegy Ltd), Sham Revitive Medic Coach (Actegy Ltd) - Diabetic Peripheral Neuropathy, Diabetic Neuropathies | Not applicable | Active not recruiting | Imperial College London | 65 | 2023-08-22 | 2025-04-09 |
| Utilizing the Michigan Neuropathy Screening Instrument for Early Detection of Diabetic Neuropathy Diabetic Polyneuropathy | Unknown | Sohag University | 100 | 2023-06-01 | 2024-07-30 |
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Diabetic Neuropathies (70) · Diabetes Mellitus (15) · Diabetes Mellitus, Type 2 (11) · Peripheral Nervous System Diseases (8) · Diabetes Mellitus, Type 1 (7) · Pain (7) · Polyneuropathies (5) · Diabetes Complications (4) · Diabetic Foot (3) · Neuralgia (3) · Neuralgia, Postherpetic (3) · Agnosia (2) · Chronic Pain (2) · Hereditary Sensory and Autonomic Neuropathies (2) · Marijuana Abuse (2)
Endocrine System Diseases (70) · Nervous System Diseases (70) · Neuromuscular Diseases (70) · Diabetes Complications (66) · Peripheral Nervous System Diseases (62) · Diabetes Mellitus (55) · Metabolic Diseases (28) · Nutritional and Metabolic Diseases (28) · Glucose Metabolism Disorders (27) · Pathological Conditions, Signs and Symptoms (17) · Signs and Symptoms (13) · Neurologic Manifestations (12) · Autoimmune Diseases (8) · Immune System Diseases (8) · Pain (5)
Thioctic Acid (3) · Duloxetine Hydrochloride (2) · Nerve Conduction Studies (2) · Physical Examination (2) · Rosuvastatin Calcium (2) · Saline Solution (2) · Standard of Care (2) · Ultrasonography (2) · 3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane (1) · 4-bromobenzoyl-(alpha-aminoisobutyric acid)(5)-leucyl-(alpha-aminoisobutyric acid)(2)-methoxy (1) · Angioplasty (1) · Baths (1) · C-Peptide (1) · Capsaicin (1) · Control Groups (1)
Sangamo Therapeutics (4) · Cairo University (3) · Umm Al-Qura University (3) · Apurano Pharmaceuticals GmbH (2) · MEDA Pharma GmbH & Co. KG (2) · Recep Tayyip Erdogan University Training and Research Hospital (2) · Aarhus University Hospital (1) · AbbVie (prior sponsor, Abbott) (1) · Abbott Medical Devices (1) · Alejandra Guillermina Miranda Diaz (1) · Ankara Etlik City Hospital (1) · Association of Extremity Nerve Surgeons (1) · Benha University (1) · Bezmialem Vakif University (1) · Chang Gung Memorial Hospital (1)
United States (17) · Germany (9) · Egypt (8) · Turkey (Türkiye) (8) · Mexico (6) · United Kingdom (5) · Canada (4) · Denmark (4) · France (3) · Saudi Arabia (3) · Italy (2) · South Korea (2) · Sweden (2) · Thailand (2) · Australia (1)
Adolfo D Rodriguez-Carrizalez, PhD, MD (1) · Ahmed Abdelalim, MD (1) · Ahmed Aly Massoud, PhD (1) · Alejandra G Miranda-Diaz, PhD,MD,FACS (1) · Alejandra G. Miranda-Diaz, MD, PhD (1) · Alper Dilli, M.D. (1) · Alun H Davies, MA DM DSC FRCS FEBVS (1) · Amira Mohamady, MD (1) · Arthur LM Swislocki, MD (1)
PMID 15277427, PMID 15504999, PMID 16558529, PMID 17065669, PMID 18060924, PMID 19317818, PMID 21775755, PMID 26290682, PMID 26498575, PMID 26994231, PMID 27312883, PMID 29189275, PMID 29381569, PMID 31994817, PMID 33794049, PMID 34963555, PMID 37101021, PMID 37716949, PMID 38516753, PMID 40050870, PMID 40127092, PMID 41239210, PMID 41366387, PMID 41627541, PMID 42795915, PMID 4567227
1DP3DK104386-01 (1), R43DK088634 (1)