56 completed, 22 unknown, 14 terminated, 6 withdrawn. 43 Not applicable, 17 Phase 2, 14 Phase 4, 13 Phase 3, 12 Phase 1.
Follow Diabetic Foot Ulcers: new trials by email Literature Review of Diabetic Foot Ulcers trials Research Report on Diabetic Foot Ulcers
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of Non Vascular Risk Factors for Severity of Diabetic Foot Ulcers (DFUs) Diabetic Foot Ulcers, Diabetes Mellitus | Not yet recruiting | Assiut University | 100 | 2025-12-01 | 2025-09-26 | |
| Wound Dressing Patch with Kelulut Honey-Infused Alginate (Tri-Gnate Alginate) for Effective Wound Care Management Tri-Gnate Alginate Dressing, Dressing product from Manuka honey, Bactigras + Dermacyn - Diabetic Foot Ulcers | Early Phase 1 | Not yet recruiting | Mohd Khairul Zul Hasymi Firdaus | 110 | 2025-11-01 | 2025-03-13 |
| Dressing Method (Self-dressing vs. Nurse-led Dressing) on Healing Outcomes in Diabetic Foot Ulcers Self-dressing, Nurse-led dressing - Dressing, Self-dressing | Not applicable | Completed | Ain Shams University | 60 | 2025-10-01 | 2026-05-22 |
| Phase II Study to Evaluate Efficacy and Safety of AMP Peptide PL-5 in Mild Infections of Diabetic Foot Ulcers Antimicrobial Peptide PL-5 Topical Spray and Placebo - Diabetic Foot Ulcers | Phase 2 | Active not recruiting | Jiangsu ProteLight Pharmaceutical & Biotechnology Co., Ltd. | 90 | 2024-01-30 | 2025-05-25 |
| The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer Methylene Blue, Milk (control), Methylene Blue and Platelet-Rich Plasma-Fibrin Glue - Diabetic Foot Ulcers, Diabetic Wound | Early Phase 1 | Unknown | Mashhad University of Medical Sciences | 20 | 2023-04-30 | 2023-10-04 |
| Topical Insulin Dressing on Management of Diabetic Foot Ulcers Insulin, Normal saline - Topical, Insulin | Not applicable | Completed | Cairo University | 30 | 2023-01-01 | 2026-02-25 |
| Registry HBOT in DFU HBOT - Diabetic Foot Ulcers | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 600 | 2022-11-01 | 2024-11-18 | |
| Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers Omeza collagen matrix, Omeza lidocaine lavage, Omeza skin protectant - Diabetic Foot Ulcers | Phase 1 | Completed | Omeza, LLC | 25 | 2022-09-01 | 2024-06-21 |
| Effectiveness of Buerger Allen Exercise Among Type 2 Diabetes Mellitus Patients With Foot Ulcer Buerger Allen Exercises - Diabetic Foot Ulcers | Not applicable | Completed | Gazi University | 72 | 2022-03-10 | 2023-02-28 |
| A Randomized,Double-blind,Placebo-controlled Clinical Study to Explore the Mechanism of Action of ON101 Cream in Patients With DFUs. ON101 Cream, Placebo - Diabetic Foot Ulcers | Not applicable | Completed | Oneness Biotech Co., Ltd. | 13 | 2021-02-23 | 2023-01-05 |
| A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Non-Healing Diabetic Foot Ulcers PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice - Diabetic Foot Ulcers | Not applicable | Unknown | PRP Concepts, LLC | 200 | 2021-01-01 | 2021-04-13 |
| Topical Oxygen Therapy for Diabetic Wounds Topical Oxygen Chamber for Extremities - Diabetic Foot Ulcers, Wound | Not applicable | Terminated | Indiana University | 4 | 2020-02-01 | 2024-04-25 |
| The Effect of Platelet-Rich Plasma-Fibrin Glue in Combination With Vitamin E and C for Treatment of Non-healing Diabetic Foot Ulcers PRP-Fibrin Glue, Vitamin E and C, Placebo - Diabetic Foot Ulcers, Diabetic Wound | Phase 2 / Phase 3 | Unknown | Mashhad University of Medical Sciences | 24 | 2019-08-28 | 2020-03-20 |
| Wound Healing Endpoint and Recurrence Epiceram Skin Barrier Function, Vaseline Petroleum Jelly - Chronic Wound, Burn Wound | Phase 1 / Phase 2 | Active not recruiting | Sashwati Roy | 100 | 2019-01-08 | 2025-09-26 |
| A Study of Granexin Gel in the Treatment of Diabetic Foot Ulcer Granexin gel, Vehicle gel - Diabetic Foot Ulcers | Phase 3 | Terminated | Xequel Bio, Inc. | 124 | 2018-11-21 | 2020-05-29 |
| Evaluate the Safety and Efficacy of RegenKit Autologous PRP Gel for the Treatment of Diabetic Foot Ulcer Autologous platelet rich plasma gel, Placebo - Diabetic Foot Ulcers | Not applicable | Unknown | Regen Lab SA | 192 | 2018-04-12 | 2020-10-08 |
| Omnigen DFU Pilot Study Omnigen, Dummy Packaging - Diabetic Foot Ulcers | Not applicable | Completed | University Hospitals of Derby and Burton NHS Foundation Trust | 31 | 2018-03-11 | 2020-01-09 |
| Evaluation of ABSOLVE in Diabetic Foot Ulcers RhPDGF-BB, Placebo - Diabetic Foot Ulcers | Phase 2 | Unknown | Lynch Biologics LLC | 40 | 2017-01-30 | 2017-01-31 |
| Effect of Fresh Amniotic Membrane in the Treatment of Diabetic Foot Ulcers Affinity Allograft, Standard of care - Diabetic Foot Ulcers | Not applicable | Completed | Organogenesis | 89 | 2016-08-01 | 2020-02-19 |
| Dehydrated Human Umbilical Cord Allograft in the Management of Diabetic Foot Ulcers EpiCord, Standard of Care - Diabetic Foot Ulcers | Not applicable | Completed | MiMedx Group, Inc. | 130 | 2016-07-01 | 2022-05-13 |
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Diabetic Foot (103) · Diabetes Mellitus (21) · Wounds and Injuries (14) · Foot Ulcer (11) · Ulcer (11) · Pressure Ulcer (8) · Varicose Ulcer (5) · Foot Diseases (4) · Burns (3) · Diabetes Complications (3) · Osteomyelitis (3) · Bronchiolitis Obliterans Syndrome (2) · Diabetic Neuropathies (2) · Leg Ulcer (2) · Surgical Wound Dehiscence (2)
Skin and Connective Tissue Diseases (103) · Cardiovascular Diseases (102) · Diabetic Angiopathies (102) · Endocrine System Diseases (102) · Skin Diseases (102) · Skin Ulcer (102) · Vascular Diseases (102) · Diabetic Neuropathies (101) · Leg Ulcer (101) · Diabetes Complications (100) · Foot Ulcer (92) · Diabetes Mellitus (82) · Nutritional and Metabolic Diseases (24) · Glucose Metabolism Disorders (23) · Metabolic Diseases (23)
Standard of Care (11) · Collagenases (4) · Becaplermin (3) · Hydrogels (3) · Ciprofloxacin (2) · Debridement (2) · Maggot Debridement Therapy (2) · Ofloxacin (2) · Saline Solution (2) · aclerastide (2) · pexiganan (2) · Acetylcysteine (1) · Alloderm (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Apligraf (1)
Healthpoint (7) · Integra LifeSciences Corporation (3) · KCI USA, Inc (3) · MiMedx Group, Inc. (3) · US Department of Veterans Affairs (3) · University of Texas Southwestern Medical Center (3) · Abeona Therapeutics, Inc (2) · Assaf-Harofeh Medical Center (2) · Cytomedix (2) · Mashhad University of Medical Sciences (2) · Molnlycke Health Care AB (2) · Osiris Therapeutics (2) · SANUWAVE, Inc. (2) · Skingenix, Inc. (2) · U.S. Wound Registry (2)
United States (67) · Canada (10) · United Kingdom (6) · Sweden (4) · Denmark (3) · Germany (3) · India (3) · Iran (3) · Spain (3) · Egypt (2) · Israel (2) · Italy (2) · China (1) · Guatemala (1) · Hungary (1)
Herbert B Slade, MD (5) · Daryoush Hamidi Alamdari, Ph.D (2) · John Fryer, Ph.D. Asst. Director (2) · Lawrence Lavery, DPM (2) · Paul Litka, MD (2) · Robert S Kirsner, MD, PhD (2) · Wijegupta Ellepola, Program Analyst (2) · Aksone Nouvong, D.P.M. (1) · Aksone Nouvong, DPM (1) · Alan Dunton, MD (1) · Albert Rabinovitz, MD (1) · Alireza Goodarzi, MSc (1) · Alisha Oropallo, MD (1) · Anders Nilsson, MD (1) · Andreas Nikolis, Dr (1)
PMID 18990064, PMID 18601587, PMID 19064169, PMID 19128245, PMID 19152653, PMID 19170984, PMID 19424751, PMID 19641161, PMID 20873963, PMID 23736928, PMID 2403699, PMID 24130347, PMID 24145042, PMID 25767565, PMID 25790480, PMID 26978860, PMID 32139102, PMID 33646060, PMID 34398099, PMID 3753059
R42DK069871 (1), R44AR046154 (1)