35 completed. 35 Phase 2, 12 Phase 1, 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 35 | Completed 35 |
| Phase 1 | 12 | Completed 12 |
| Phase 3 | 8 | Completed 8 |
Follow Death: new trials by email Literature Review of Death trials Research Report on Death
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss Cabergoline 1 MG, Placebo - Lactation Suppressed | Phase 2 | Completed | Stanford University | 69 | 2024-02-07 | 2025-10-03 |
| Mutation-specific Therapy for the Long QT Syndrome Lumacaftor / Ivacaftor, Orkambi® Oral Tablet - Long QT Syndrome | Phase 2 | Completed | Istituto Auxologico Italiano | 16 | 2021-06-15 | 2025-04-25 |
| Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss Cabergoline 1 MG, Placebo - Lactation Suppressed | Phase 2 | Completed | Stanford University | 73 | 2021-04-01 | 2024-02-13 |
| RGX-121 Gene Therapy in Children 5 Years of Age and Over With MPS II (Hunter Syndrome) RGX-121 - Mucopolysaccharidosis Type II (MPS II) | Phase 1 / Phase 2 | Completed | REGENXBIO Inc. | 6 | 2021-03-11 | 2025-01-28 |
| Autologous Cord Blood Cells for Prevention of BPD in Preterm Autologous Umbilical Cord Blood Mononuclear Cells infusion Therapy, 0.9% Sodiun Chloride - Safety Issues, BPD - Bronchopulmonary Dysplasia | Phase 2 | Completed | yangjie | 62 | 2018-07-01 | 2020-06-02 |
| Autologous Cord Blood Mononuclear Cells for Bronchopulmonary Dysplasia in Very Preterm Neonates Autologous Umbilical Cord Blood Mononuclear Cells Therapy - Bronchopulmonary Dysplasia, Premature | Phase 2 | Completed | Guangdong Women and Children Hospital | 62 | 2018-07-01 | 2021-11-02 |
| Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant CD3/CD19 neg allogeneic BMT - Primary Immunodeficiency, PID | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 5 | 2017-12-01 | 2025-07-22 |
| Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI Fluoxetine, Placebo - Epilepsy, SUDEP | Phase 2 | Completed | Rup Kamal Sainju | 30 | 2017-02-16 | 2020-05-04 |
| Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Hydrocortisone, Placebo - Hypoxic-Ischemic Encephalopathy, Asphyxia | Phase 2 / Phase 3 | Completed | Semmelweis University | 32 | 2016-02-01 | 2023-04-21 |
| A Comparison Between Home-made Vitrification & Thawing Media and a Commercially Available Brand on Blastocyst home made vitrification & thawing kit, commercially made vitrification & thawing kit - Blastocyst Disintegration | Phase 2 / Phase 3 | Completed | Benha University | 74 | 2015-10-01 | 2018-09-07 |
| Naloxone for Optimizing Hypoxemia Of Lung Donors Naloxone, Normal saline - Brain Death, Organ Donors | Phase 2 / Phase 3 | Completed | Washington University School of Medicine | 199 | 2015-09-01 | 2020-07-31 |
| Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment idursulfase-IT, No IT treatment - Hunter Syndrome | Phase 2 / Phase 3 | Completed | Shire | 58 | 2014-03-24 | 2021-06-11 |
| Vitamin D and Cardiac Autonomic Tone in Hemodialysis Alfacalcidol, Ergocalciferol - Cardiovascular Disease, Sudden Cardiac Death | Phase 2 | Completed | University of Calgary | 56 | 2013-01-01 | 2016-08-31 |
| Study to Improve Survival Among HIV-Exposed Infants in Botswana cotrimoxazole prophylaxis, cotrimoxazole placebo, exclusive breastfeeding until 6 months of age - HIV Infections, Neutropenia | Phase 2 | Completed | Harvard School of Public Health (HSPH) | 3724 | 2011-05-01 | 2019-09-09 |
| Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation Coenzyme Q10, Placebo - Cardiac Arrest, Sudden Cardiac Arrest | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 10 | 2011-02-01 | 2017-07-31 |
| Improving Quality of Care for the Dying Patient in Hospice: A Quasi Experimental Trial in Liguria Region LCP Program - End-of-Life | Phase 2 | Completed | Regional Palliative Care Network | 282 | 2010-09-01 | 2013-01-14 |
| An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment Idursulfase-IT, Elaprase - Hunter Syndrome | Phase 1 / Phase 2 | Completed | Takeda | 15 | 2010-08-01 | 2025-08-06 |
| Meaning-based Group Counselling for Bereavement Meaning-Based Bereavement Group, Conventional Bereavement Group - Grief, Bereavement | Phase 2 | Completed | Jewish General Hospital | 26 | 2010-06-01 | 2013-11-08 |
| To Evaluate the Safety and Efficacy of GC1111 (Recombinant Human Iduronate-2-sulfatase) in Hunter Syndrome Patients GC1111_0.5mg/kg, GC1111_1.0mg/kg, Elaprase_0.5mg/kg - Mucopolysaccharidosis II | Phase 1 / Phase 2 | Completed | Green Cross Corporation | 31 | 2010-05-01 | 2012-02-14 |
| A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase® Control, Idursulfase IT (1 mg), Idursulfase IT (10 mg) - Hunter Syndrome | Phase 1 / Phase 2 | Completed | Shire | 16 | 2009-11-18 | 2021-06-28 |
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Mucopolysaccharidosis II (7) · Sudden Infant Death (7) · Death, Sudden, Cardiac (6) · Lysosomal Storage Diseases (4) · Asphyxia (3) · Brain Death (3) · Breast Feeding (3) · Hypoxia-Ischemia, Brain (3) · Perinatal Death (3) · Anemia (2) · Bronchopulmonary Dysplasia (2) · Cardiovascular Diseases (2) · Hemorrhage (2) · Hyperemia (2)
Pathologic Processes (35) · Pathological Conditions, Signs and Symptoms (35) · Nervous System Diseases (15) · Death, Sudden (14) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Cardiovascular Diseases (11) · Neurologic Manifestations (11) · Neurobehavioral Manifestations (10) · Genetic Diseases, Inborn (9) · Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (8) · Brain Diseases (7) · Carbohydrate Metabolism, Inborn Errors (7) · Central Nervous System Diseases (7)
Sodium Chloride (4) · idursulfase (3) · Cabergoline (2) · Abciximab (1) · Aging (1) · Albuterol (1) · Clopidogrel (1) · Docosahexaenoic Acids (1) · Eptifibatide (1) · Ergocalciferols (1) · Fluoxetine (1) · Geritol (1) · Hydrocortisone (1) · Iduronate Sulfatase (1) · Lactation (1)
Shire (4) · Aalborg University Hospital (2) · Stanford University (2) · Zhengzhou University (2) · Benha University (1) · Beth Israel Deaconess Medical Center (1) · Campus Bio-Medico University (1) · Green Cross Corporation (1) · Guangdong Women and Children Hospital (1) · Harvard School of Public Health (HSPH) (1) · Icahn School of Medicine at Mount Sinai (1) · Istituto Auxologico Italiano (1) · Jewish General Hospital (1) · King's College London (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1)
United States (15) · Canada (8) · United Kingdom (6) · China (4) · Italy (4) · Brazil (3) · Germany (3) · Denmark (2) · France (2) · Spain (2) · Australia (1) · Botswana (1) · Democratic Republic of the Congo (1) · Egypt (1) · Hungary (1)
Changlian Zhu, MD, PhD (2) · Jie Yang, PHD (2) · Andrew Levey, M.D. (1) · Annapoorna S Kini, MD MRCP (1) · Dr. Brenda Hemmelgarn, MD, PhD, MN (1) · Dr. Derek Exner, MD, MPH (1) · Dr. Sofia B Ahmed, MD, MMSc (1) · Francesco M Serino, MD (1) · Giuseppe Rosano, MD (1) · Irene J Higginson, BMBS FRCP FFPHM PhD (1) · Jeppe H Christensen, MD, DMSci (1) · Kodondi K Koto, MD, PhD (1) · Lia Crotti, MD (1) · Lorraine B Ware, M.D. (1)
PMID 16553654, PMID 17058754, PMID 18507817, PMID 18805742, PMID 19022547, PMID 19280394, PMID 19833477, PMID 20809942, PMID 20955600, PMID 21150784, PMID 21190486, PMID 21482964, PMID 21978993, PMID 22929184, PMID 23497636, PMID 23837440, PMID 23884915, PMID 24445353, PMID 25098377, PMID 27690095, PMID 28339500, PMID 28395844, PMID 28943384, PMID 29119726, PMID 29760559, PMID 30399122, PMID 30629045, PMID 31155392, PMID 33874971, PMID 35588317, PMID 35961250, PMID 36027721, PMID 36864985, PMID 37486652, PMID 37863161, PMID 37915038, PMID 37997800, PMID 40983658, PMID 41538804, PMID 42522264
2004 (1), R01HD061265 (1), U01AI125050 (1), U01DK061700 (1)