15 completed. 15 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 15 |
| Phase 2 | 7 | Completed 7 |
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops® Relative to INBRIJA® Levodopa Cyclops®, INBRIJA® - Parkinson, Parkinson Disease | Phase 1 | Completed | PureIMS B.V. | 26 | 2023-09-25 | 2025-05-31 |
| Neuroimmune Dysfunction in Alcohol Use Disorder Minocycline, Sugar pill - Alcohol Drinking, Alcohol-Related Disorders | Phase 1 | Completed | University of Maryland, Baltimore | 142 | 2020-02-03 | 2023-12-01 |
| A Proof-of-Concept Study of Minocycline in Autism Minocycline, Placebos - Autism Spectrum Disorder, Autism | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 53 | 2019-04-19 | 2020-12-08 |
| Minocycline's Effects on Alcohol Responses in Humans Minocycline, Placebo (for Minocycline) - Alcohol Dependence | Phase 1 | Completed | Yale University | 54 | 2015-07-01 | 2020-03-09 |
| Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa Minocycline - Retinitis Pigmentosa | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 7 | 2014-05-01 | 2024-04-17 |
| The Effects of Minocycline in Humans Sugar pill, Minocycline - Memory Impairment | Phase 1 | Completed | Yale University | 10 | 2013-07-08 | 2019-09-19 |
| Minocycline Bioequivalence Study Minocycline - Skin Diseases | Phase 1 | Completed | GlaxoSmithKline | 28 | 2013-05-01 | 2013-11-18 |
| A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients Minocycline - Intracerebral Hemorrhage | Phase 1 / Phase 2 | Completed | Augusta University | 16 | 2013-02-01 | 2018-04-26 |
| Minocycline to Treat Branch Retinal Vein Occlusion Minocycline, Placebo, Bevacizumab - Retinal Vein Occlusion | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 9 | 2012-03-28 | 2022-01-26 |
| Bioequivalence Minocycline Bioequivalence Minocycline 100mg - Skin Infections (Acne) | Phase 1 | Completed | GlaxoSmithKline | 25 | 2011-06-17 | 2017-06-22 |
| A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema Minocycline - Diabetic Macular Edema | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 6 | 2010-04-01 | 2014-10-17 |
| Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) Minocycline - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Wayne State University | 15 | 2010-02-01 | 2018-09-17 |
| Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke Minocycline - Stroke, Acute | Phase 1 / Phase 2 | Completed | David Hess, MD | 60 | 2008-05-01 | 2012-01-13 |
| Role of Minocycline in First Episode Psychosis Minocycline, Placebo - First Episode Psychosis | Phase 1 / Phase 2 | Completed | Stanley Medical Research Institute | 52 | 2006-05-01 | 2009-06-15 |
| Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms minocycline, doxycycline - Aneurysms, Arteriovenous Malformations | Phase 1 | Completed | University of California, San Francisco | 26 | 2004-07-01 | 2013-10-09 |
Alcoholism (2) · Macular Edema (2) · Stroke (2) · Acne Vulgaris (1) · Alcohol Drinking (1) · Alcohol-Related Disorders (1) · Aneurysm (1) · Arteriovenous Malformations (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Brain Injuries, Traumatic (1) · Cellulitis (1) · Cerebral Hemorrhage (1) · Chemically-Induced Disorders (1)
Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Brain Diseases (4) · Cardiovascular Diseases (4) · Central Nervous System Diseases (4) · Vascular Diseases (4) · Mental Disorders (3) · Pathologic Processes (3) · Cerebrovascular Disorders (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Eye Diseases (2) · Macular Degeneration (2) · Retinal Degeneration (2) · Retinal Diseases (2) · Skin and Connective Tissue Diseases (2)
Minocycline (14) · Sugars (2) · Bevacizumab (1) · Dihydroxyphenylalanine (1) · Doxycycline (1) · Tetracycline (1)
National Eye Institute (NEI) (3) · GlaxoSmithKline (2) · Yale University (2) · Augusta University (1) · Children's Hospital Medical Center, Cincinnati (1) · David Hess, MD (1) · PureIMS B.V. (1) · Stanley Medical Research Institute (1) · University of California, San Francisco (1) · University of Maryland, Baltimore (1) · Wayne State University (1)
United States (11) · Brazil (1) · Bulgaria (1) · Mexico (1) · Pakistan (1) · United Kingdom (1)
Catherine A Cukras, M.D. (2) · Allen Lamb, DO (1) · Catherine A Cukras, MD, PhD (1) · Craig Erickson (1) · David C Hess, MD (1) · Imran B Chaudhry, MD (1) · Ismene Petrakis, M.D. (1) · Ivo Bogdanov, MD (1) · Jaime EC Hallak, MD (1) · Jay M Meythaler, MD (1) · Jeffrey A Switzer, DO (1) · John Fath, MD (1) · Kristina Freese, PA (1)
PMID 18212521, PMID 20705929, PMID 22589436, PMID 28887388, PMID 30744442, PMID 36882562, PMID 40483726
2023 (1), K01AA026005 (1), R21AA023150 (1)