38 completed, 10 unknown, 4 terminated, 3 recruiting. 58 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 58 | Completed 38, Unknown 10, Terminated 4, Recruiting 3, Not yet recruiting 2, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia Tobramycin inhalation solution, 0.9% Sodium Chloride Placebo - Pneumonia, Ventilator-Associated | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 574 | 2026-10-07 | 2026-10-02 |
| Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning airway clearance, subglottic secretion aspiration, Ceftriaxone 2 grams daily - Intubation Complication, Stroke, Ischemic | Phase 4 | Not yet recruiting | Hospital San Carlos, Madrid | 60 | 2026-09-15 | 2026-08-06 |
| Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated Pneumonia strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology - Ventilator Associated Pneumonia ( VAP) | Phase 4 | Recruiting | Centre Hospitalier Universitaire de Nīmes | 124 | 2026-03-27 | 2026-10-13 |
| A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis Inhaled amikacin, Placebo - Hepatic Encephalopathy, Cirrhosis | Phase 4 | Recruiting | Asian Institute of Gastroenterology, India | 162 | 2025-02-12 | 2025-04-04 |
| Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation Oroxid®, Chlorhexidine mouthwash - VAP - Ventilator Associated Pneumonia | Phase 4 | Unknown | Charles University, Czech Republic | 160 | 2024-05-01 | 2024-07-26 |
| Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics - Ventilator Associated Pneumonia ( VAP) | Phase 4 | Completed | Postgraduate Medical Institute, Lahore | 90 | 2024-01-05 | 2026-01-27 |
| EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics Rapid Diagnostics - Blood Stream Infections, Ventilator Associated Pneumonia | Phase 4 | Recruiting | National University of Singapore | 1526 | 2023-12-12 | 2026-10-22 |
| The Duration of Antibiotic Therapy for Early (DATE) Ventilator Associated Pneumonia (VAP): 4 vs. 7 Days Standard of Care Antibiotic Therapy - Ventilator Associated Pneumonia | Phase 4 | Terminated | University of Miami | 27 | 2023-05-08 | 2026-01-16 |
| Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patients Ambroxol Hydrochloride, Standard Therapy - Severe Pneumonia, Community-acquired Pneumonia | Phase 4 | Completed | National University of Malaysia | 32 | 2023-01-07 | 2023-12-27 |
| Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections Minocycline, Levofloxacin or Cotrimoxazole, Placebo - Hospital Infections | Phase 4 | Unknown | Mahidol University | 112 | 2022-11-24 | 2023-01-10 |
| Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery Tranexamic Acid, Placebos - Infection Wound, Gastrointestinal Complication | Phase 4 | Completed | Bayside Health | 3300 | 2022-05-18 | 2025-12-31 |
| Early Antibiotics After Aspiration in ICU Patients Ceftriaxone, Amoxicillin clavulanic acid, Cefepime - Aspiration, Aspiration Pneumonia | Phase 4 | Terminated | UConn Health | 5 | 2021-11-30 | 2025-12-30 |
| Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults Zavicefta, Ceftazidime-Avibactam, Best Available Treatment - Urinary Tract Infection, Acute Pyelonephritis | Phase 4 | Completed | Pfizer | 60 | 2021-08-26 | 2024-10-21 |
| Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs. Colistin - Hospital Infection, Multi-antibiotic Resistance | Phase 4 | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 20 | 2021-07-14 | 2021-08-06 |
| Efficacy and Safety of Ceftazidime-Avibactam (CAZ-AVI) in Chinese Participants With HAP (Including VAP) Zavicefta, Ceftazidime-Avibactam - Hospital-Acquired Pneumonia | Phase 4 | Completed | Pfizer | 235 | 2021-05-21 | 2024-09-19 |
| Treatment of Nosocomial COVID-19 Anti-SARS-CoV-2 mAb - Covid19, Nosocomial Infection | Phase 4 | Terminated | University of Calgary | 46 | 2021-02-12 | 2023-04-19 |
| Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia Simvastatin - VAP - Ventilator Associated Pneumonia | Phase 4 | Completed | Ain Shams University | 161 | 2021-01-01 | 2022-02-09 |
| Demonstration Project on Health Care Worker Protection Against Hepatitis B in Kalulushi District Engerix-B - Hepatitis B Virus, Health Care Associated Infection | Phase 4 | Completed | Centre for Infectious Disease Research in Zambia | 641 | 2019-11-25 | 2026-08-10 |
| Administration of Zepatier (Grazoprevir Plus Elbasvir) in Chronic Hemodialysis (HD) Patients With Hepatitis C Elbasvir 50 MG / Grazoprevir 100 MG [Zepatier] - Hepatitis C, Hemodialysis | Phase 4 | Completed | University of Pennsylvania | 6 | 2019-09-22 | 2021-12-15 |
| VITAL - VAP Prevention by BIP (Bactiguard Infection Protection) ETT Evac in Belgian ICUs ETTEvac, BIP ETTEvac - Ventilator-associated Pneumonia | Phase 4 | Completed | Bactiguard AB | 323 | 2018-10-31 | 2021-01-20 |
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Pneumonia, Ventilator-Associated (37) · Healthcare-Associated Pneumonia (10) · Pneumonia (5) · Critical Illness (4) · Infections (4) · Urinary Tract Infections (4) · Intraabdominal Infections (3) · Community-Acquired Pneumonia (2) · Pneumonia, Aspiration (2) · Sepsis (2) · Staphylococcal Infections (2) · Appendicitis (1) · Asthma (1) · Bacteremia (1)
Disease Attributes (58) · Iatrogenic Disease (58) · Pathologic Processes (58) · Pathological Conditions, Signs and Symptoms (58) · Infections (54) · Lung Diseases (43) · Respiratory Tract Diseases (43) · Respiratory Tract Infections (43) · Pneumonia (38) · Healthcare-Associated Pneumonia (32) · Bacterial Infections and Mycoses (6) · Bacterial Infections (5) · Digestive System Diseases (4) · Female Urogenital Diseases (4)
Vancomycin (4) · Ceftriaxone (3) · Doripenem (3) · Imipenem (3) · Amoxicillin-Potassium Clavulanate Combination (2) · Chlorhexidine (2) · Cilastatin, Imipenem Drug Combination (2) · Colistin (2) · Inhalation (2) · Levofloxacin (2) · Linezolid (2) · Saline Solution (2) · Tobramycin (2) · avibactam, ceftazidime drug combination (2) · chlorhexidine gluconate (2)
Pfizer (4) · Sutep Jaruratanasirikul (3) · Bactiguard AB (2) · Hospital Universitario de Canarias (2) · Mahidol University (2) · Ain Shams University (1) · Asian Institute of Gastroenterology, India (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Barnes-Jewish Hospital (1) · Bayside Health (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier Universitaire de Nīmes (1) · Centre for Infectious Disease Research in Zambia (1) · Charles University, Czech Republic (1)
United States (12) · Thailand (8) · France (5) · Malaysia (5) · India (4) · Spain (4) · Brazil (3) · Canada (3) · China (3) · Argentina (2) · Belgium (2) · Chile (2) · Colombia (2) · Egypt (2) · Germany (2)
Sutep Jaruratanasirikul, MD (3) · Adhiratha Boonyasiri, MD (1) · Ahlem Trifi (1) · Alain Tremblay (1) · Apostolos Armaganidis, MD, PhD (1) · Benoit Misset, MD,Prof. (1) · Brandon Oto (1) · Carlos A Cadavid, MD (1) · Charis Roussos, MD, PhD (1) · Christof von Eiff, MD (1) · David Paterson, Professor (1) · Deborah J Cook, MD (1) · Dilip R Karnad, MD,FACP,FRCP (1)
PMID 17872488, PMID 11778260, PMID 11888973, PMID 17291803, PMID 17954800, PMID 18626628, PMID 18707849, PMID 18719064, PMID 20670293, PMID 21478738, PMID 22422274, PMID 22483191, PMID 22952580, PMID 23778831, PMID 24011955, PMID 24279701, PMID 24636429, PMID 24700659, PMID 25602496, PMID 26196695, PMID 27033711, PMID 27044546, PMID 27143787, PMID 27600290, PMID 29741298, PMID 30267930, PMID 30409160, PMID 31227528, PMID 31783881, PMID 34473343, PMID 34546300, PMID 34871241, PMID 34981245, PMID 35394515, PMID 35724443, PMID 36682909, PMID 37815567, PMID 39340688, PMID 39731129, PMID 41013603, PMID 41248372, PMID 42829121
2014 (1), 2025 (1)