13 completed, 4 unknown, 3 recruiting, 2 active not recruiting. 25 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 13, Unknown 4, Recruiting 3, Active not recruiting 2, Not yet recruiting 1, Suspended 1, Terminated 1 |
| Phase 2 | 4 | Completed 2, Unknown 2 |
Follow Craniofacial Abnormalities: new trials by email Literature Review of Craniofacial Abnormalities trials Research Report on Craniofacial Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| Futibatinib (TAS-120) in Patients With Advanced Biliary Tract Cancer Futibatinib, Zimberelimab, Durvalumab - Biliary Tract Cancer | Phase 3 | Recruiting | Taiho Pharmaceutical Co., Ltd. | 784 | 2026-06-24 | 2026-07-17 |
| Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders Lonapegsomatropin [SKYTROFA®], Somatropin Pen Injector - Turner Syndrome, Short Stature Homeobox Gene Mutation | Phase 3 | Recruiting | Ascendis Pharma A/S | 186 | 2025-12-12 | 2026-11-05 |
| Liposomal Bupivacaine Use in Alveolar Bone Graft Patients Liposomal Bupivacaine, Bupivacain, Epinephrine - Cleft Lip and Palate | Phase 3 | Unknown | Kerry O'Rourke | 60 | 2024-04-24 | 2024-07-03 |
| Augmented Reality for Orthognatic Surgery Patient Education Patient consultation - Malocclusion, Dentofacial Deformities | Phase 2 / Phase 3 | Completed | University Medical Center Groningen | 60 | 2023-10-01 | 2025-03-30 |
| A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9 Somapacitan - SGA, Turner Syndrome | Phase 3 | Active not recruiting | Novo Nordisk A/S | 47 | 2023-02-01 | 2026-08-13 |
| Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin - Retrognathism, Prognathism | Phase 2 / Phase 3 | Unknown | Universitat Internacional de Catalunya | 220 | 2022-09-30 | 2022-09-13 |
| A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow Somapacitan, Norditropin® - SGA, Turner Syndrome, Noonan Syndrome, ISS | Phase 3 | Active not recruiting | Novo Nordisk A/S | 412 | 2022-08-10 | 2026-06-12 |
| A Single Bolus of Dexmedetomidine Versus Normal Saline in Postoperative Agitation Dexmedetomidine, 0.9% saline - Cleft Palate | Phase 3 | Completed | Assiut University | 60 | 2021-06-20 | 2026-05-07 |
| Nebulized Bupivacaine Analgesia for Cleft Palate Repair Bupivacaine Hydrochloride, 0.9% saline - Cleft Palate | Phase 3 | Recruiting | Assiut University | 60 | 2021-06-14 | 2026-09-09 |
| Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome Simvastatin, Placebo - Noonan Syndrome | Phase 3 | Completed | University Hospital, Toulouse | 53 | 2017-01-25 | 2023-05-11 |
| Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery Tranexamic Acid, saline solution - Peri-operative Hemorrhage or Hematoma, Surgery | Phase 3 | Completed | University Hospital, Lille | 157 | 2016-01-03 | 2026-04-22 |
| Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Levobupivacaine, Bupivacaine - Recovery After Cleft Palate Surgery | Phase 2 / Phase 3 | Completed | Assiut University | 60 | 2016-01-01 | 2017-09-07 |
| Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. omega-3 PUFAs, Standard care, placebo - 22q11 Deletion Syndrome | Phase 2 / Phase 3 | Unknown | Bambino Gesù Hospital and Research Institute | 80 | 2014-06-01 | 2014-02-25 |
| Investigating the Long-term Efficacy and Safety of Two Doses of NN-220 (Somatropin) in Short Stature Due to Noonan Syndrome somatropin - Genetic Disorder, Noonan Syndrome | Phase 3 | Completed | Novo Nordisk A/S | 51 | 2013-08-19 | 2020-08-10 |
| Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid Tranexamic Acid, Saline Placebo - Craniosynostoses | Phase 3 | Suspended | The Hospital for Sick Children | 90 | 2010-01-01 | 2019-07-15 |
| Comparative Results of Maxillary Deficiency Treatment by Fixed Tongue Appliance and Fixed Facemask in Growing Patients Fixed Tongue Appliance, Fixed Face Mask - Maxillary Deficiency | Phase 3 | Unknown | Shahid Beheshti University | 20 | 2009-06-01 | 2010-07-27 |
| Genetic Testing of Noonan Subjects Previously Treated With Norditropin®. An Extension to Trial GHNOO-1658 somatropin - Genetic Disorder, Noonan Syndrome | Phase 3 | Completed | Novo Nordisk A/S | 22 | 2008-09-01 | 2023-08-09 |
| Comparative Results of Maxillary Deficiency Treatment by Tongue Plate and Facemask in Growing Patients Tongue plate, Facemask - Maxillary Deficiency | Phase 3 | Completed | Shahid Beheshti University of Medical Sciences | 20 | 2007-09-01 | 2008-12-19 |
| Oral Cleft Prevention Program Folic acid: 4 mg versus 0.4 mg per day - Cleft Lip, Cleft Palate | Phase 3 | Completed | University of Iowa | 4000 | 2006-11-01 | 2017-03-31 |
Showing 20 of 25. Sign in to see all of them.
Noonan Syndrome (9) · Cleft Palate (7) · Retrognathia (4) · Cleft Lip (3) · Genetic Diseases, Inborn (3) · Turner Syndrome (3) · 22q11 Deletion Syndrome (1) · Acrocephalosyndactylia (1) · Agnosia (1) · Biliary Tract Neoplasms (1) · Chromosome Disorders (1) · Congenital Abnormalities (1) · Craniosynostoses (1) · Dentofacial Deformities (1) · DiGeorge Syndrome (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (25) · Musculoskeletal Abnormalities (25) · Musculoskeletal Diseases (25) · Congenital Abnormalities (24) · Maxillofacial Abnormalities (12) · Stomatognathic Diseases (12) · Stomatognathic System Abnormalities (12) · Cardiovascular Abnormalities (11) · Cardiovascular Diseases (11) · Heart Defects, Congenital (11) · Heart Diseases (11) · Jaw Abnormalities (11) · Jaw Diseases (11) · Connective Tissue Diseases (9)
Human Growth Hormone (5) · Bupivacaine (4) · Saline Solution (3) · Folic Acid (2) · Tranexamic Acid (2) · somapacitan (2) · Cisplatin (1) · Cytidine (1) · Dexmedetomidine (1) · Epinephrine (1) · Fish Oils (1) · Gemcitabine (1) · Hydroxocobalamin (1) · Ketorolac (1) · Levobupivacaine (1)
Novo Nordisk A/S (5) · Assiut University (3) · The Hospital for Sick Children (2) · Ascendis Pharma A/S (1) · Bambino Gesù Hospital and Research Institute (1) · Carelon Research (1) · Kerry O'Rourke (1) · NICHD Global Network for Women's and Children's Health (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1) · Sanofi (1) · Shahid Beheshti University (1) · Shahid Beheshti University of Medical Sciences (1) · Taiho Pharmaceutical Co., Ltd. (1) · Universitat Internacional de Catalunya (1) · University Hospital, Lille (1)
United States (6) · France (5) · South Korea (4) · Canada (3) · Egypt (3) · Germany (3) · Japan (3) · Netherlands (3) · Spain (3) · Brazil (2) · Iran (2) · Italy (2) · Malaysia (2) · Poland (2) · Sweden (2)
Chad A. Purnell, MD (1) · Elsa Jozefowicz, MD (1) · J Kraeima, dr. (1) · Jason Hayes, MD (1) · Jeff Murray, M.D. (1) · Jeffrey Murray, MD (1) · Lida Toomarian (1) · Mahkameh Mirkarimi (1) · Marco Armando, MD, PhD (1)
PMID 16203673, PMID 19854614, PMID 21091369, PMID 23181832, PMID 23669628, PMID 24525630, PMID 29109363, PMID 32269181, PMID 34465477, PMID 41285480, PMID 41712606, PMID 41774755, PMID 42069961, PMID 42621140
2005 (1), 2008 (1), 2015 (1), U01DE017958 (1)