10 completed, 2 unknown, 2 withdrawn, 1 recruiting. 6 Phase 2, 4 Not applicable, 4 Phase 4, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 2, Withdrawn 2, Terminated 1, Unknown 1 |
| Not applicable | 4 | Completed 4 |
| Phase 4 | 4 | Completed 3, Unknown 1 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Hydroxocobalamin: new trials by email Literature Review of Hydroxocobalamin trials Research Report on Hydroxocobalamin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hydroxocobalamin Approach for Reducing of Calprotectin With Butyrate for Ulcerative Colitis Remission Hydroxocobalamin with Butyrate, Placebo with Butyrate - Ulcerative Colitis | Phase 2 | Withdrawn | Joshua Korzenik | 2024-01-01 | 2024-04-22 | |
| A Study on Hydroxocobalamin Given to Healthy Individual to Monitor Symptoms Hydroxocobalamin - Hydroxocobalamin Adverse Reaction | Phase 1 | Completed | Brigham and Women's Hospital | 10 | 2023-01-02 | 2026-03-13 |
| Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin - Retrognathism, Prognathism | Phase 2 / Phase 3 | Unknown | Universitat Internacional de Catalunya | 220 | 2022-09-30 | 2022-09-13 |
| SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells Melphalan, BCNU, Vitamin B12B - Pancreatic Adenocarcinoma Metastatic, BRCA1 Mutation | Phase 1 | Recruiting | General Oncology, Inc. | 24 | 2021-01-13 | 2026-01-29 |
| Do Iron And Vitamin B12 Injections Given Together, Improve Hemoglobin In Patients On Hemodialysis? Ferric carboxymaltose, Hydroxycobalamin, Placebo - Iron Deficiency Anemia, B12 Deficiency Anemia | Phase 4 | Unknown | Christian Medical College, Vellore, India | 100 | 2020-11-18 | 2021-01-29 |
| Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients Hydroxocobalamin, Methylene Blue - Vasoplegic Syndrome, Liver Transplant; Complications | Phase 4 | Completed | Mayo Clinic | 19 | 2019-11-30 | 2024-06-24 |
| Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery Hydroxocobalamin, Methylene Blue, Normal saline - Vasoplegia, Hypotension | Phase 2 | Withdrawn | Dartmouth-Hitchcock Medical Center | 2019-11-01 | 2020-03-02 | |
| Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass Hydroxycobalamin - Vasoplegic Syndrome | Phase 2 / Phase 3 | Completed | Ain Shams University | 60 | 2019-08-28 | 2024-06-12 |
| A Trial of Vitamin B12 in Septic Shock Hydroxocobalamin, Placebo - Septic Shock | Phase 2 | Completed | Medical College of Wisconsin | 20 | 2019-08-05 | 2026-05-27 |
| Vitamin B12a Vasoplegic Syndrome Hydroxocobalamin, Cardiopulmonary Bypass, Placebos - Vasoplegic Syndrome | Phase 2 | Terminated | Mayo Clinic | 8 | 2019-04-25 | 2023-05-10 |
| Megadose of Hydroxocobalamin for the Treatment of Pernicious Anemia Hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg - Megaloblastic Anemia Nos, Pernicious Anemia | Phase 4 | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 13 | 2017-12-27 | 2021-03-08 |
| Vitamin Deficiencies and Suppletion in Morbid Obesity Hydroxocobalamin, FitForMe vitamin B12 - Vitamin B12 Deficiency | Phase 4 | Completed | Rijnstate Hospital | 50 | 2014-10-01 | 2020-06-11 |
| B Vitamin Status in Premature and Small for Gestational Age(SGA) Infants Hydroxycobalamin, Sham injection - Biochemical Cobalamin Status, Motor Neurodevelopment | Not applicable | Completed | Haukeland University Hospital | 80 | 2009-07-01 | 2010-09-14 |
| Cobalamin Status in Young Children With Developmental Delay Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma) - Vitamin B 12 Deficiency | Not applicable | Completed | Haukeland University Hospital | 100 | 2008-06-01 | 2010-08-16 |
| Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma) - Vitamin B 12 Deficiency | Not applicable | Completed | Haukeland University Hospital | 100 | 2008-04-01 | 2010-08-16 |
| Cobalamin Supplementation During Infancy; Effect on B-vitamin Status, Growth and Psychomotor Development Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma) - Vitamin B 12 Deficiency | Not applicable | Completed | Haukeland University Hospital | 107 | 2004-12-01 | 2015-07-21 |
Vasoplegia (4) · Vitamin B 12 Deficiency (4) · Hypotension (2) · Anemia, Iron-Deficiency (1) · Anemia, Megaloblastic (1) · Anemia, Pernicious (1) · Breast Feeding (1) · Breast Neoplasms (1) · Colitis, Ulcerative (1) · Coronary Artery Disease (1) · Deficiency Diseases (1) · Heart Valve Diseases (1) · Inflammatory Bowel Diseases (1) · Neoplasm Metastasis (1) · Neurologic Manifestations (1)
Haukeland University Hospital (4) · Mayo Clinic (2) · Ain Shams University (1) · Brigham and Women's Hospital (1) · Christian Medical College, Vellore, India (1) · Dartmouth-Hitchcock Medical Center (1) · General Oncology, Inc. (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Joshua Korzenik (1) · Medical College of Wisconsin (1) · Rijnstate Hospital (1) · Universitat Internacional de Catalunya (1)
United States (7) · Norway (4) · Egypt (1) · India (1) · Mexico (1) · Netherlands (1)
Per Magne Ueland, M.D., Ph.D. (2) · Anna T Valson, MD, DM (1) · Arnold Glazier, M.D. (1) · Dina Badre, MD (1) · James A. Nelson, M.B.B.S. (1) · Jayshil J Patel, MD (1) · Joshua R Korzenik, MD (1) · Pedro Sole, DMD, OMFS (1) · Rizwan Alam, MD (1) · Sher-Lu Pai, MD (1)
PMID 24025626, PMID 14616423, PMID 18595990, PMID 22650964, PMID 23168578, PMID 23697526, PMID 26678525, PMID 28360040, PMID 29931179, PMID 36174744