8 unknown, 5 completed, 2 not yet recruiting, 2 recruiting. 6 Not applicable, 6 Phase 2, 3 Phase 4, 2 Phase 1, 1 Early Phase 1.
Follow Bromelains: new trials by email Literature Review of Bromelains trials Research Report on Bromelains
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus Topical Bromelain, 0.1% topical triamcinolone acetonide, Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase - Oral Lichen Planus | Phase 2 | Recruiting | Cairo University | 42 | 2026-02-18 | 2026-06-09 |
| Bromelain for Post-surgery Facial Swelling Bromelain - Malocclusion | Not applicable | Recruiting | Mohamed Bazina | 200 | 2025-09-08 | 2026-06-05 |
| The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain Trypsin, Bromelain and Rutoside, Diclofenac Potassium 50mg Tab, Prednisolone Oral Tablet - Symptomatic Irreversible Pulpitis | Not applicable | Completed | Cairo University | 124 | 2025-06-15 | 2026-07-22 |
| Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis 35% Topical Bromelain in Orabase, 50% Topical Bromelain in Orabase, 0.1% Topical Triamcinolone Acetonide in Orabase - Recurrent Aphthous Stomatitis | Phase 2 | Not yet recruiting | Cairo University | 63 | 2025-06-15 | 2025-05-28 |
| Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease combination of diosmin, hesperidin, bromelain, and Ruscus aculeatus (Vesvein Gambe) - Prodromal to Chronic Venous Disease | Not applicable | Completed | Ekalab S.r.l. | 80 | 2025-05-28 | 2026-05-22 |
| The Effects of Bromelain Supplement in Patients with Diabetic Foot Ulcers Bromelain, Placebo - Diabetic Foot Ulcer (DFU) | Phase 3 | Not yet recruiting | Dr Azita Hekmatdoost | 70 | 2025-03-01 | 2025-01-22 |
| Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars bromelain, Calcium hydroxide - Intracanal Medication, Bromelain | Early Phase 1 | Unknown | Cairo University | 30 | 2023-02-10 | 2023-01-18 |
| BromAc for Recurrent Peritoneal Mucinous Tumour or Pseudomyxoma Peritonei Bromelain, Acetylcysteine, Interventional radiology insertion of drain - Pseudomyxoma Peritonei, Peritoneal Cancer | Phase 2 | Unknown | Mucpharm Pty Ltd | 62 | 2022-05-01 | 2022-03-15 |
| Safety of Nebulized Combination Therapy BromAc® in COVID-19 Respiratory Disease Bromelains, Acetylcysteine - COVID-19 Pneumonia, COVID-19 | Phase 1 / Phase 2 | Unknown | Mucpharm Pty Ltd | 30 | 2022-05-01 | 2022-02-28 |
| Intratumoral Bromelain + Acetylcysteine in Relapsed and Unresectable Pseudomyxoma Peritonei Bromelin, N-Acetylcysteine - Pseudomyxoma Peritonei | Phase 1 | Unknown | Maimónides Biomedical Research Institute of Córdoba | 10 | 2021-09-13 | 2022-06-02 |
| Effects of Bromelain and Boswellia Serrata Casperome With Centella Asiatica and Vitamins on Edema, Paresthesia and Postoperative Pain After Quadrantectomy With or Without Sentinel Lymph Node Biopsy. Bromelain/Boswellia Serrata Casperome, Centella Asiatica/Vitamins, Placebo - Breast Cancer Female, Pain, Postoperative | Phase 4 | Unknown | University of Bari Aldo Moro | 120 | 2020-12-31 | 2020-12-16 |
| Bromelain and Escin in the Reduction of Postoperative Sequelae in Periodontal and Implant Surgery Bromelains and Escin Oral Tablet, Placebo - Postoperative Pain, Edema | Not applicable | Completed | University of L'Aquila | 20 | 2020-12-01 | 2021-09-13 |
| The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19 Quercetin, bromelain, Zinc - Covid-19 | Phase 4 | Unknown | Ministry of Health, Saudi Arabia | 60 | 2020-06-20 | 2020-07-13 |
| Arnica Montana and Bromelain in Rhinoplasty Arnica Montana, Bromelain, Placebo - Wound Healing | Not applicable | Withdrawn | Boston Medical Center | 2019-08-01 | 2019-08-15 | |
| Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse Bromelain, Powdered sugar - Dental Plaque, Dental Caries | Phase 2 | Completed | Indiana University | 46 | 2018-06-14 | 2020-12-03 |
| Bromelain, Comosain as a New Drug for Treating and Preventing Various Types of Cancer in the Humans Bromelain and Comosain - Cancer | Phase 2 | Unknown | Oeyama-Moto Cancer Research Foundation | 100 | 2014-05-01 | 2015-01-19 |
| Bromelain and Cardiovascular Risk Factors in Diabetes bromelain capsule, placebo (wheat starch) - Cardiovascular Disease. | Not applicable | Completed | Hebei Yiling Hospital | 72 | 2011-06-01 | 2012-09-24 |
| Bromelin, a Compound Prepared With Ananas Comocus Extract and Honey, for Acute Cough Bromelin, Placebo - Cough, Acute | Phase 4 | Unknown | Universidade Federal de Pernambuco | 102 | 2011-06-01 | 2011-06-28 |
COVID-19 (2) · Pain, Postoperative (2) · Pseudomyxoma Peritonei (2) · Adenocarcinoma, Mucinous (1) · Breast Neoplasms (1) · Cardiovascular Diseases (1) · Common Cold (1) · Cough (1) · Dental Caries (1) · Dental Plaque (1) · Diabetic Foot (1) · Edema (1) · Facies (1) · Lichen Planus, Oral (1) · Malocclusion (1)
Cairo University (4) · Mucpharm Pty Ltd (2) · Boston Medical Center (1) · Dr Azita Hekmatdoost (1) · Ekalab S.r.l. (1) · Hebei Yiling Hospital (1) · Indiana University (1) · Maimónides Biomedical Research Institute of Córdoba (1) · Ministry of Health, Saudi Arabia (1) · Mohamed Bazina (1) · Oeyama-Moto Cancer Research Foundation (1) · Universidade Federal de Pernambuco (1) · University of Bari Aldo Moro (1) · University of L'Aquila (1)
United States (4) · Italy (3) · Egypt (2) · Brazil (1) · China (1) · Iran (1) · Saudi Arabia (1) · Spain (1)
Alvaro Arjona Sanchez, MD (1) · Armando Sardi, MD (1) · Benedict Liao, M.D. (1) · Decio M Peixoto, MD, PhD (1) · Edward Levine, MD (1) · Emanuel SC Sarinho, MD, PhD (1) · Frank MP van Haren, MD, PhD (1) · Haroon Choudry, MD (1) · Ignace de Hingh, MD (1) · Jacqueline Wulu, MD (1) · Kamyab Andarzbakhsh, PharmD (1) · Kelton Stewart, DDS, MS (1) · Ley C M, Ms (1)