21 completed, 10 unknown, 7 recruiting, 5 terminated. 23 Not applicable, 3 Phase 2, 3 Phase 3, 3 Phase 4, 1 Early Phase 1.
Follow Chronic Respiratory Failure: new trials by email Literature Review of Chronic Respiratory Failure trials Research Report on Chronic Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport Advanced Respiratory Support During Patient Transport - Acute Respiratory Failure, Respiratory Insufficiency | Not yet recruiting | Medipol University | 565 | 2026-12-31 | 2026-09-04 | |
| A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) Non-invasive ventilation - Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure | Phase 2 | Recruiting | University of Pennsylvania | 48 | 2026-06-11 | 2026-06-26 |
| Validation of the Turkish Version of the S3-NIV Questionnaire Turkish Version of the S3-NIV Questionnaire - Respiratory Insufficiency, Chronic Respiratory Failure | Not yet recruiting | Istanbul Saglik Bilimleri University | 120 | 2026-05-21 | 2026-05-28 | |
| Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia Usual Oxygen During 6-Minute Walk Test, Supplemental Oxygen During 6-Minute Walk Test - Chronic Respiratory Failure, Hypoxemia | Not applicable | Recruiting | Istituti Clinici Scientifici Maugeri SpA | 114 | 2026-04-02 | 2026-06-23 |
| Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory Failure High-Flow Nasal Cannula (HFNC) Oxygen Therapy, Oxygen therapy - Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease | Not applicable | Recruiting | Università degli Studi di Ferrara | 16 | 2025-11-05 | 2026-10-08 |
| From Bench to Bedside: A Machine Learning Tool for the Detection of Inspiratory Leak Chronic Respiratory Failure | Recruiting | University of Oslo | 20 | 2025-10-01 | 2026-02-24 | |
| Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure Emily.AI - Chronic Respiratory Failure, Acute Respiratory Failure | Not applicable | Recruiting | Aether Tech S.L. | 20 | 2025-04-23 | 2026-01-09 |
| Improving Chronic Nocturnal Noninvasive Ventilation: a Multimodality Approach Non-invasive ventilation - Chronic Respiratory Failure, Non-invasive Ventilation | Recruiting | University Medical Center Groningen | 100 | 2024-12-01 | 2026-07-02 | |
| Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study Mechanical insufflation - Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure | Not applicable | Completed | University of Pennsylvania | 23 | 2024-09-12 | 2026-08-12 |
| Closed-loop syncHronization vErsuS convenTional Synchronization in sPontaneously Breathing Adult Nonivasive ventilationPatients close-loop synchronization controller with spontaneous mode, Conventional - Acute Respiratory Failure, Acute Respiratory Distress Syndrome | Not applicable | Recruiting | Başakşehir Çam & Sakura City Hospital | 38 | 2024-04-08 | 2025-03-26 |
| Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency NIV initiation in patients with ALS - Ventilation Therapy, ALS | Not applicable | Active not recruiting | Tampere University | 120 | 2024-03-05 | 2026-08-11 |
| Fibroblast Growth Factor 23 in Chronic Respiratory Failure Dosage, Cardiac echography - Chronic Respiratory Failure | Unknown | Assistance Publique - Hôpitaux de Paris | 50 | 2023-06-01 | 2023-04-18 | |
| Clinical Impact of Patient-ventilator Asynchrony Transcutaneous Capnography - Chronic Respiratory Failure, Non-invasive Ventilation | Completed | Nantes University Hospital | 35 | 2023-06-01 | 2025-03-04 | |
| Family Connections Structured Family Deliberation - Chronic Respiratory Failure | Not applicable | Withdrawn | Johns Hopkins All Children's Hospital | 2022-07-01 | 2023-06-23 | |
| Parental Perception of COVID-19 Vaccine in Technology Dependent Patients COVID 19 vaccine counseling - Chronic Respiratory Failure, Tracheostomy Complication | Completed | Northwell Health | 60 | 2021-09-23 | 2022-07-18 | |
| Treatment of CRF With Syndrome Differentiation of TCM Placebo, Traditional Chinese medicine prescription - Chronic Respiratory Failure | Early Phase 1 | Unknown | Henan University of Traditional Chinese Medicine | 120 | 2021-01-01 | 2021-01-06 |
| Study on Optimal Oxygen Concentration During Pulmonary Rehabilitation High-flow nasal cannula, Low SpO2 - High-flow Nasal Cannula, Exercise Capacity | Not applicable | Unknown | National Hospital Organization Minami Kyoto Hospital | 32 | 2020-07-18 | 2023-03-28 |
| COVID-19 Related Lockdown Effects On Chronic Diseases life questionnaires, questionnaire - Chronic Coronary Syndrome, Heart Failure | Completed | Centre Hospitalier Universitaire Dijon | 1343 | 2020-04-14 | 2026-02-02 | |
| Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure Yiqi Huoxue Huatan granule, Placebo Yiqi Huoxue Huatan granule - Chronic Obstructive Pulmonary Disease, Chronic Respiratory Failure | Phase 3 | Unknown | Peking University People's Hospital | 372 | 2019-10-08 | 2020-01-07 |
| Microbiologic Contamination of Home Non Invasive Ventilators Microbiological sampling - Chronic Respiratory Failure, COPD | Terminated | University Hospital, Rouen | 54 | 2019-01-21 | 2019-09-04 |
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Pulmonary Disease, Chronic Obstructive (9) · Respiratory Insufficiency (7) · Neuromuscular Diseases (4) · Amyotrophic Lateral Sclerosis (3) · Hypercapnia (2) · Hypoxia (2) · Lung Diseases (2) · Obesity Hypoventilation Syndrome (2) · Patient-Ventilator Asynchrony (2) · Respiratory Aspiration (2) · Bronchopulmonary Dysplasia (1) · Cardiomegaly (1) · Cough (1) · Critical Illness (1) · Cystic Fibrosis (1)
Respiratory Tract Diseases (24) · Pathological Conditions, Signs and Symptoms (20) · Pathologic Processes (13) · Respiration Disorders (13) · Lung Diseases (12) · Disease Attributes (11) · Chronic Disease (10) · Nervous System Diseases (10) · Lung Diseases, Obstructive (9) · Signs and Symptoms (9) · Signs and Symptoms, Respiratory (8) · Nutritional and Metabolic Diseases (5) · Respiratory Insufficiency (5) · Central Nervous System Diseases (4) · Dyssomnias (4)
Noninvasive Ventilation (4) · Oxygen Inhalation Therapy (2) · Albuterol (1) · Budesonide (1) · Clinical Protocols (1) · Congresses as Topic (1) · Continuous Positive Airway Pressure (1) · Dietary Supplements (1) · Educational Status (1) · Inhalation (1) · Mass Screening (1) · Menogaril (1) · Physical Therapists (1) · Positive-Pressure Respiration (1) · Prescriptions (1)
Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche (2) · Fondazione Salvatore Maugeri (2) · National Hospital Organization Minami Kyoto Hospital (2) · University Hospital, Rouen (2) · University of Pennsylvania (2) · A.O.U. Città della Salute e della Scienza (1) · Aether Tech S.L. (1) · Assistance Publique - Hôpitaux de Paris (1) · Başakşehir Çam & Sakura City Hospital (1) · Centre Hospitalier Universitaire Dijon (1) · Centre d'Investigation Clinique et Technologique 805 (1) · Cochin Hospital (1) · Dokuz Eylul University (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Groupe de Recherche sur le Handicap Respiratoire (1)
France (12) · Italy (7) · United States (6) · Turkey (Türkiye) (4) · Japan (3) · Spain (2) · Brazil (1) · China (1) · Colombia (1) · Egypt (1) · Finland (1) · Germany (1) · Netherlands (1) · Norway (1) · Qatar (1)
Antonio M Esquinas (1) · Carme Puy, MD (1) · Dieter Koehler, M.D., Prof. (1) · Dominic Dellweg, M.D. (1) · Frederic Lofaso, Md-PhD (1)
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